公开(公告)号：US20230250143A1

公开(公告)日：2023-08-10

申请号：US18164297

申请日：2023-02-03

Applicant: Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin ,  OptoGenTech GmbH

Inventor： Tobias MOSER ,  Thomas MAGER ,  Maria ZERCHE

IPC: C07K14/47 ,  A61K48/00 ,  A61K38/17 ,  A61P27/02 ,  A61P27/16

CPC classification number: C07K14/47 ,  A61K48/0075 ,  A61K38/1709 ,  A61P27/02 ,  A61P27/16

Abstract: The present invention relates to a mutant ion channel capable of being activated by light (‘light-activated’ ion channel) and having improved properties, nucleic acids and expression vectors encoding the mutant ion channel, cells comprising such nucleic acid or expression vector, devices containing the mutant ion channel, nucleic acid or expression vector as well as respective uses and methods.