公开(公告)号：US12128062B2

公开(公告)日：2024-10-29

申请号：US17258544

申请日：2019-08-14

Applicant: Ohannes Kevork Melemedjian

Inventor： Ohannes Kevork Melemedjian

IPC: C12N15/11 ,  A61K31/16 ,  A61K31/19 ,  A61K31/7004 ,  A61K31/7105 ,  A61K47/54 ,  C12N15/113

CPC classification number: A61K31/7105 ,  A61K31/16 ,  A61K31/19 ,  A61K31/7004 ,  A61K47/543 ,  A61K47/549 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/346

Abstract: Methods of alleviating or prophylactically blocking pain through the alteration of certain metabolic pathways in a subject experiencing pain or expecting to experience pain are disclosed. In particular, methods of increasing the amount of the neutral amino acid transporter ASCT2 in neurons are disclosed. Increased glutamine uptake by neurons leads to reduced extrusion of lactate and protons into the extracellular space and by extension, reduced sensitization of the neurons. Reduced sensitization of the neurons lessens the feeling of pain in the subject.

公开(公告)号：US20210161944A1

公开(公告)日：2021-06-03

申请号：US17258544

申请日：2019-08-14

Applicant: Ohannes Kevork MELEMEDJIAN

Inventor： Ohannes Kevork MELEMEDJIAN

IPC: A61K31/7105 ,  A61K31/19 ,  A61K31/16 ,  A61K31/7004 ,  A61K47/54 ,  C12N15/113

Abstract: Methods of alleviating or prophylactically blocking pain through the alteration of certain metabolic pathways in a subject experiencing pain or expecting to experience pain are disclosed. In particular, methods of increasing the amount of the neutral amino acid transporter ASCT2 in neurons are disclosed. Increased glutamine uptake by neurons leads to reduced extrusion of lactate and protons into the extracellular space and by extension, reduced sensitization of the neurons. Reduced sensitization of the neurons lessens the feeling of pain in the subject.