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公开(公告)号：US20230322876A1
公开(公告)日：2023-10-12
申请号：US18328528
申请日：2023-06-02
Applicant: OTHAIR PROTHENA LIMITED
Inventor： Robin Barbour , Gene Kinney , Wagner Zago , Tarlochan S. Nijjar
CPC classification number: C07K14/4711 , A61P25/28 , A61P37/04 , A61K39/0007 , A61K39/39 , A61K2039/53 , A61K2039/545 , A61K2039/55516 , A61K2039/55544 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , A61K2039/6037 , C07K2319/00
Abstract: The disclosure provides peptide compositions and immunotherapy compositions comprising an amyloid-beta (Aβ) peptide and a tau peptide. The disclosure also provides methods of treating or effecting prophylaxis of Alzheimer's disease or other diseases with beta-amyloid deposition in a subject, including methods of clearing deposits, inhibiting or reducing aggregation of Aβ and/or tau, blocking the uptake by neurons, clearing amyloid, and inhibiting propagation of tau seeds in a subject having or at risk of developing Alzheimer's disease or other diseases containing tau and/or amyloid-beta accumulations. The methods include administering to such patients the compositions comprising an amyloid-beta (Aβ) peptide and a tau peptide.
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公开(公告)号：US20230355729A1
公开(公告)日：2023-11-09
申请号：US18245532
申请日：2021-08-06
Applicant: Robin BARBOUR , Gene KINNEY , Wagner ZAGO , OTHAIR PROTHENA LIMITED
Inventor： Robin Barbour , Gene Kinney , Wagner Zago
CPC classification number: A61K39/0007 , A61P25/28 , A61K2039/6037 , A61K2039/55505 , A61K2039/55566 , A61K2039/55572
Abstract: The disclosure provides peptide compositions and immunotherapy compositions comprising an amyloid-beta (Aβ) peptide and an alpha-synuclein peptide. The disclosure also provides methods of treating or effecting prophylaxis of Alzheimer's disease or other diseases with beta-amyloid deposition in a subject, including methods of clearing deposits, inhibiting or reducing aggregation of Aβ and/or alpha-synuclein, blocking the uptake by neurons, clearing amyloid, and inhibiting propagation of alpha-synuclein seeds in a subject having or at risk of developing Alzheimer's disease or other diseases containing alpha-synuclein and/or amyloid-beta accumulations. The methods include administering to such patients the compositions comprising an amyloid-beta (Aβ) peptide and an alpha-synuclein peptide.
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公开(公告)号：US20240343769A1
公开(公告)日：2024-10-17
申请号：US18594435
申请日：2024-03-04
Applicant: OTHAIR PROTHENA LIMITED
Inventor： Robin BARBOUR , Gene KINNEY , Wagner ZAGO , Tarlochan S. NIJJAR
CPC classification number: C07K14/4711 , A61K39/0007 , A61K39/39 , A61P25/28 , A61P37/04 , A61K2039/53 , A61K2039/545 , A61K2039/55516 , A61K2039/55544 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , A61K2039/6037 , C07K2319/00
Abstract: The disclosure provides peptide compositions and immunotherapy compositions comprising an amyloid-beta (Aβ) peptide and a tau peptide. The disclosure also provides methods of treating or effecting prophylaxis of Alzheimer's disease or other diseases with beta-amyloid deposition in a subject, including methods of clearing deposits, inhibiting or reducing aggregation of Aβ and/or tau, blocking the uptake by neurons, clearing amyloid, and inhibiting propagation of tau seeds in a subject having or at risk of developing Alzheimer's disease or other diseases containing tau and/or amyloid-beta accumulations. The methods include administering to such patients the compositions comprising an amyloid-beta (Aβ) peptide and a tau peptide.
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公开(公告)号：US11965005B2
公开(公告)日：2024-04-23
申请号：US18328557
申请日：2023-06-02
Applicant: OTHAIR PROTHENA LIMITED
Inventor： Robin Barbour , Gene Kinney , Wagner Zago , Tarlochan S. Nijjar
CPC classification number: C07K14/4711 , A61K39/0007 , A61K39/39 , A61P25/28 , A61P37/04 , A61K2039/53 , A61K2039/545 , A61K2039/55516 , A61K2039/55544 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , A61K2039/6037 , C07K2319/00
Abstract: The disclosure provides peptide compositions and immunotherapy compositions comprising an amyloid-beta (Aβ) peptide and a tau peptide. The disclosure also provides methods of treating or effecting prophylaxis of Alzheimer's disease or other diseases with beta-amyloid deposition in a subject, including methods of clearing deposits, inhibiting or reducing aggregation of Aβ and/or tau, blocking the uptake by neurons, clearing amyloid, and inhibiting propagation of tau seeds in a subject having or at risk of developing Alzheimer's disease or other diseases containing tau and/or amyloid-beta accumulations. The methods include administering to such patients the compositions comprising an amyloid-beta (Aβ) peptide and a tau peptide.
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公开(公告)号：US20230183304A1
公开(公告)日：2023-06-15
申请号：US17925813
申请日：2021-05-19
Applicant: Robinoo BARBOUR , Gene KINNEY , Wagner ZAGO , Tarlochan S. NIJJAR , OTHAIR PROTHENA LIMITED
Inventor： Robin Barbour , Gene Kinney , Wagner Zago , Tarlochan Nijjar
CPC classification number: C07K14/4711 , A61P25/28 , A61K39/0007 , A61K39/39 , A61P37/04 , A61K2039/55516 , A61K2039/55577 , A61K2039/55572 , A61K2039/55555 , C07K2319/00 , A61K2039/53 , A61K2039/55544 , A61K2039/545 , A61K2039/575 , A61K2039/6037
Abstract: The disclosure provides peptide compositions and immunotherapy compositions comprising an amyloid-beta (Aβ) peptide and a fau. peptide. The disclosure also provides methods of treating or effecting prophylaxis of Alzheimer's disease or oilier diseases with beta-amyloid deposition in a subject, including methods of clearing deposits, inhibiting or reducing aggregation of Aβ and/or tan, blocking the uptake by neurons, clearing amyloid, and inhibiting propagation of tau seeds in a subject having or at risk of developing Alzheimer's disease or other diseases containing tau and/or amyloid-beta accumulations. The methods include administering to such patients the compositions comprising an amyloid-beta (Aβ) peptide and a tau peptide.
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Patent Agency Ranking
公开(公告)号：US20220089762A1
公开(公告)日：2022-03-24
申请号：US17510160
申请日：2021-10-25
Applicant: OTHAIR PROTHENA LIMITED
Inventor： Michael SKOV , Tarlochan S. NIJJAR , Sridhar GOVINDARAJAN , Tom PURCELL , Mark WELCH , Frédérique BARD , Robin BARBOUR , Wagner ZAGO
Abstract: Antibodies that bind human beta-amyloid peptide, methods of detecting, measuring and treating amyloidogenic disorders with said antibodies, pharmaceutical compositions comprising the antibodies and methods of manufacture are provided.
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公开(公告)号：US20230364210A1
公开(公告)日：2023-11-16
申请号：US18245523
申请日：2021-05-19
Applicant: OTHAIR PROTHENA LIMITED
Inventor： Robin Barbour , Gene Kinney , Wagner Zago
CPC classification number: A61K39/0007 , A61P25/28 , C07K7/06 , C07K7/08 , A61K2039/545 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , A61K2039/6037
Abstract: The disclosure provides peptide compositions and immunotherapy compositions comprising an amyloid-beta (Aβ) peptide. The disclosure also provides methods of treating or effecting prophylaxis of Alzheimer’s disease or other diseases with beta-amyloid deposition in a subject, including methods of clearing deposits, inhibiting or reducing aggregation of Aβ, blocking the uptake by neurons, and clearing amyloid in a subject having or at risk of developing Alzheimer’s disease or other diseases containing amyloid-beta accumulations. The methods include administering to such patients the compositions comprising an. amyloid-beta (Aβ) peptide.
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公开(公告)号：US20230312662A1
公开(公告)日：2023-10-05
申请号：US18328557
申请日：2023-06-02
Applicant: OTHAIR PROTHENA LIMITED
Inventor： Robin Barbour , Gene Kinney , Wagner Zago , Tarlochan S. Nijjar
CPC classification number: C07K14/4711 , A61P25/28 , A61P37/04 , A61K39/0007 , A61K39/39 , A61K2039/53 , A61K2039/545 , A61K2039/55516 , A61K2039/55544 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , A61K2039/6037 , C07K2319/00
Abstract: The disclosure provides peptide compositions and immunotherapy compositions comprising an amyloid-beta (Aβ) peptide and a tau peptide. The disclosure also provides methods of treating or effecting prophylaxis of Alzheimer's disease or other diseases with beta-amyloid deposition in a subject, including methods of clearing deposits, inhibiting or reducing aggregation of Aβ and/or tau, blocking the uptake by neurons, clearing amyloid, and inhibiting propagation of tau seeds in a subject having or at risk of developing Alzheimer's disease or other diseases containing tau and/or amyloid-beta accumulations. The methods include administering to such patients the compositions comprising an amyloid-beta (Aβ) peptide and a tau peptide.
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公开(公告)号：US20230302127A1
公开(公告)日：2023-09-28
申请号：US18020037
申请日：2021-05-19
Applicant: OTHAIR PROTHENA LIMITED
Inventor： Robin Barbour , Gene Kinney , Wagner Zago , Tarlochan S. Nijjar
IPC: A61K39/395 , A61P25/28
CPC classification number: A61K39/3955 , A61P25/28 , A61K2039/6037
Abstract: The disclosure provides peptides, peptide compositions, immunotherapy compositions, pharmaceutical compositions and nucleic acids comprising one or more tau peptides. The disclosure also provides methods of treating or effecting prophylaxis of Alzheimer's disease or other diseases characterized at least in part by aberrant tau pathology (e.g., aggregation in neurofibrillary tangles) in a subject, including methods of clearing deposits, inhibiting or reducing aggregation of tau, blocking the uptake by neurons, clearing tau, and inhibiting propagation of tau seeds in a subject having or at risk of developing Alzheimer's disease or other diseases containing tau accumulations. The methods include administering to such patients the compositions comprising one or more tau peptides.
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公开(公告)号：US11440953B2
公开(公告)日：2022-09-13
申请号：US17725363
申请日：2022-04-20
Applicant: OTHAIR PROTHENA LIMITED
Inventor： Michael Skov , Tarlochan S. Nijjar , Frédérique Bard , Robin Barbour , Wagner Zago
Abstract: Antibodies that bind human beta-amyloid peptide, methods of detecting, measuring and treating amyloidogenic disorders with said antibodies, pharmaceutical compositions comprising the antibodies and methods of manufacture are provided.
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