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    CRYSTALLINE SUBSTITUTED PYRAZINES AS PGI2 RECEPTOR AGONISTS
    2.
    发明申请
    CRYSTALLINE SUBSTITUTED PYRAZINES AS PGI2 RECEPTOR AGONISTS 有权

    公开(公告)号：US20250034098A1

    公开(公告)日：2025-01-30

    申请号：US18918427

    申请日：2024-10-17

    Applicant: NIPPON SHINYAKU CO., LTD.

    Inventor： Toshio FUJIWARA

    IPC: C07D241/20 ,  C07D241/26

    Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”). A form-I crystal of Compound B, which shows peaks at diffraction angles (2θ) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-Kα radiation (λ=1.54 Å). A form-II crystal of Compound B, which shows peaks at diffraction angles (2θ) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-Kα radiation (λ=1.54 Å).

    MEASURING CONTAINER
    3.
    发明公开
    MEASURING CONTAINER 审中-公开

    公开(公告)号：US20240199309A1

    公开(公告)日：2024-06-20

    申请号：US18591369

    申请日：2024-02-29

    Applicant: NIPPON SHINYAKU CO., LTD.

    Inventor： Masaki HAYAKAWA

    IPC: B65D83/04

    CPC classification number: B65D83/0409

    Abstract: A measuring container comprises a storage container and a storage section selector. The storage container includes storage sections each capable of storing a predetermined number of tablets. The storage section selector is attached to the storage container and has a second path that allows the tablets to pass through from one end to an other end. The one end of the second path is connected to an outside, and the other end is selectively connected to one of the storage sections.

    ANTISENSE NUCLEIC ACID ENABLING EXON SKIPPING
    4.
    发明申请
    ANTISENSE NUCLEIC ACID ENABLING EXON SKIPPING 有权

    公开(公告)号：US20230045557A1

    公开(公告)日：2023-02-09

    申请号：US17785565

    申请日：2020-12-18

    Applicant: NIPPON SHINYAKU CO., LTD. ,  NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY

    Inventor： Naoki WATANABE ,  Yuichiro TONE ,  Shin'ichi TAKEDA ,  Yoshitsugu AOKI

    IPC: C12N15/113

    Abstract: The present specification provides an antisense oligomer capable of causing simultaneous skipping of a plurality of exons in pre-mRNA of interest, and a pharmaceutical composition comprising the oligomer. The present specification also provides an antisense oligomer or a pharmaceutically acceptable salt thereof, or hydrate thereof which causes simultaneous skipping of two or more numerically consecutive exons from pre-mRNA of interest, the antisense oligomer comprising a base sequence complementary to a base sequence of a region including the vicinity of a donor of any intron in the pre-mRNA of interest, or a region including the vicinity of an acceptor of any intron in the pre-mRNA of interest, or a partial base sequence thereof.

    MEASURING CONTAINER, LOADING TOOL, AND MEASURING CONTAINER KIT
    5.
    发明申请
    MEASURING CONTAINER, LOADING TOOL, AND MEASURING CONTAINER KIT 有权

    公开(公告)号：US20220227567A1

    公开(公告)日：2022-07-21

    申请号：US17605611

    申请日：2020-04-08

    Applicant: NIPPON SHINYAKU CO., LTD.

    Inventor： Masaki HAYAKAWA

    IPC: B65D83/04

    Abstract: A measuring container comprises a storage container and a storage section selector. The storage container includes storage sections each capable of storing a predetermined number of tablets. The storage section selector is attached to the storage container and has a second path that allows the tablets to pass through from one end to an other end. The one end of the second path is connected to an outside, and the other end is selectively connected to one of the storage sections.

    CRYSTAL
    10.
    发明申请
    CRYSTAL 审中-公开

    公开(公告)号：US20200223804A1

    公开(公告)日：2020-07-16

    申请号：US16650390

    申请日：2018-09-27

    Applicant: NIPPON SHINYAKU CO., LTD.

    Inventor： Toshio FUJIWARA

    IPC: C07D241/20

    Abstract: A main object of the present invention is to provide a novel crystal of 2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid (hereinafter referred to as “Compound B”).A form-I crystal of Compound B, which shows peaks at diffraction angles (2θ) of 6.4°, 8.1°, 9.5°, 10.9°, 13.2°, 15.7°, 17.0°, 19.5°, 20.3°, 21.0°, and 22.8° in a powder X-ray diffraction spectrum obtained using a Cu-Kα radiation (λ=1.54 Å).A form-III crystal of Compound B, which shows peaks at diffraction angles (2θ) of 9.6°, 11.4°, 11.7°, 16.3°, 17.5°, 18.5°, 18.7°, 19.9°, 20.1°, 21.0°, and 24.6° in a powder X-ray diffraction spectrum obtained using a Cu-Kα radiation (λ=1.54 Å).

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