公开(公告)号：US20240130709A1

公开(公告)日：2024-04-25

申请号：US18538944

申请日：2023-12-13

Applicant: The Board of Regents of The University of Texas System ,  NONINVASIX, INC.

Inventor： DONALD S. PROUGH, III ,  YURIY PETROV ,  CHARLES HOUSSIERE ,  IRENE PETROV ,  TRIS MILLER

IPC: A61B8/00 ,  A61B5/00 ,  A61B5/145

CPC classification number: A61B8/4236 ,  A61B5/0095 ,  A61B5/14542 ,  A61B8/4416 ,  A61B8/463 ,  A61B8/54

Abstract: Apparatus and methods are described for ultrasound guided optoacoustic monitoring to provide diagnostic information for many clinical applications of blood oxygenation in blood vessels and in tissues including for early diagnosis and management of circulatory shock (including that induced by hemorrhage). In certain embodiments provided herein, methods and apparatus for optoacoustics for measurement of blood oxygenation in the innominate vein are provided. In certain embodiments provided herein, are methods and apparatus for articulating an angle between an ultrasound probe and subject body to identify an optimum position for an optoacoustic probe to measure blood oxygenation in a target blood vessel or tissue.

公开(公告)号：US10231656B2

公开(公告)日：2019-03-19

申请号：US14794037

申请日：2015-07-08

Applicant: NONINVASIX, INC.

Inventor： Rinat Esenaliev ,  Donald S. Prough ,  Yuriy Petrov ,  Irene Petrov ,  George Saade ,  Gayle L. Olson ,  Tommy G. Cooper

IPC: A61B5/1455 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1464 ,  A61B5/1459

Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.

公开(公告)号：US20190216376A1

公开(公告)日：2019-07-18

申请号：US16253678

申请日：2019-01-22

Applicant: Noninvasix, Inc. ,  The Board of Regents of The University of Texas

Inventor： Rinat ESENALIEV ,  Donald S. PROUGH ,  Yuriy PETROV ,  Irene PETROV ,  George SAADE ,  Gayle L. OLSON ,  Tommy G. COOPER

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1464 ,  A61B5/1459 ,  A61B5/1455

CPC classification number: A61B5/14542 ,  A61B5/0095 ,  A61B5/14551 ,  A61B5/14553 ,  A61B5/1459 ,  A61B5/1464 ,  A61B5/6814 ,  A61B5/6875 ,  A61B5/742 ,  A61B2560/0425 ,  A61B2562/0271

Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.

公开(公告)号：US20230233088A1

公开(公告)日：2023-07-27

申请号：US18187614

申请日：2023-03-21

Applicant: Noninvasix, Inc. ,  The Board of Regents of The University of Texas System

Inventor： Rinat ESENALIEV ,  Irene Petrov ,  Yuriy Petrov

IPC: A61B5/00 ,  A61B5/1455

CPC classification number: A61B5/0095 ,  A61B5/14551 ,  A61B2562/0204

Abstract: The systems, devices, and methods herein make optoacoustic measurements and correct or normalize them for variations in optical energy level of the different light pulses used. An optical source directs optical pulses to tissue, an optical energy meter measures the optical energy of the different optical pulses, an acoustic detector measures an acoustic response generated by the tissue in response to the optical pulses, and a processor calculates a concentration of an analyte based on the measured acoustic response and as corrected or normalized for the different energy levels among the optical pulses.

公开(公告)号：US11045121B2

公开(公告)日：2021-06-29

申请号：US16253678

申请日：2019-01-22

Applicant: Noninvasix, Inc. ,  The Board of Regents of The University of Texas

Inventor： Rinat Esenaliev ,  Donald S. Prough ,  Yuriy Petrov ,  Irene Petrov ,  George Saade ,  Gayle L. Olson ,  Tommy G. Cooper

IPC: A61B5/1455 ,  A61B5/145 ,  A61B5/00 ,  A61B5/1464 ,  A61B5/1459

Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.

公开(公告)号：US20160015304A1

公开(公告)日：2016-01-21

申请号：US14794037

申请日：2015-07-08

Applicant: NONINVASIX, INC.

Inventor： Rinat ESENALIEV ,  Donald S. PROUGH ,  Yuriy PETROV ,  Irene PETROV ,  George SAADE ,  Gayle L. OLSON ,  Tommy G. COOPER

IPC: A61B5/145 ,  A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/14542 ,  A61B5/0095 ,  A61B5/14553 ,  A61B5/1459 ,  A61B5/1464 ,  A61B5/6814 ,  A61B5/6875 ,  A61B5/742 ,  A61B2562/0271

Abstract: Optoacoustic diagnostic systems, devices, and methods are described. A system may comprise a console unit and a handheld probe. The console unit comprises a controller, a processor, a photodiode array, an acoustic processing subsystem, and a cooling subsystem. The probe directs light signals from the photodiode array to patient tissue. The light signals each have different wavelengths selected based on the physiological parameter of interest. The probe further comprises an acoustic transducer that receives acoustic signals generated in response to the directed light signals. The probe may comprise a finger-held working end that can be directed to the skull of a fetus within the uterus during labor. The probe can then accurately determine blood oxygenation of the fetus to determine if a caesarian section is necessary.