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公开(公告)号：US10730888B2
公开(公告)日：2020-08-04
申请号：US15549034
申请日：2016-02-05
Applicant: Mylan Laboratories Ltd.
Inventor： Sivaram Prasad Vellanki , Madumurthy Nadella , Mitali Bhalme , Revathi Srinivas Ramabhotla , Venkata Siva Reddy Arumalla , Raveendra Babu Kilaru
IPC: C07D498/14 , C07D211/14 , C07C229/30 , C07F5/02 , C07C227/18 , C07C227/10 , C07D211/02 , C07D211/86
Abstract: Processes for the preparation of dolutegravir and pharmaceutically acceptable salts utilizing alkenylamine are disclosed. Intermediates in those synthetic schemes are also disclosed.
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2.发明授权公开(公告)号：US10391178B2
公开(公告)日：2019-08-27
申请号：US15127612
申请日：2015-03-20
Applicant: MYLAN LABORATORIES LTD.
Inventor： Ramesh Dandala , Sivarama Prasad Vellanki , Raja Babu Balusu , Subbarayudu Putta
IPC: C07D413/12 , A61K31/513 , A61K47/26 , A61K9/00 , A61K47/38 , A61P31/18
Abstract: The present disclosure provides a process for the preparation a premix of raltegravir potassium form 3 with excipients. This premix may be used in the manufacture of pharmaceutical formulations containing raltegravir.
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公开(公告)号：US20170319539A1
公开(公告)日：2017-11-09
申请号：US15515787
申请日：2015-10-01
Applicant: Mylan Laboratories LTD.
Inventor： Ramakoteswara Rao Jetti , Aggi Ramireddy Bommareddy , Amit Singh , Vijaya Krishna Ravi , Subramanyam Dandala
IPC: A61K31/351 , A61K45/06 , A61K31/155 , A61K31/522 , C07D407/12 , A61K47/40
CPC classification number: A61K31/351 , A61K31/155 , A61K31/522 , A61K45/06 , A61K47/40 , C07D407/12
Abstract: The present disclosure relates to solid dispersion of amorphous empagliflozin and its process thereof.
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公开(公告)号：US20170035911A1
公开(公告)日：2017-02-09
申请号：US15039774
申请日：2014-11-28
Applicant: MYLAN LABORATORIES LTD.
Inventor： Ramakoteswara Rao JETTI , Balakrishna Reddy BHOGALA , Aggi Rami Reddy BOMMAREDDY , Anjaneya Raju INDUKURI
IPC: A61K47/48 , A61K31/5377 , A61K9/10
CPC classification number: A61K47/6951 , A61K9/10 , A61K9/1652 , A61K9/205 , A61K31/5377
Abstract: The present disclosure relates to a solid dispersion of amorphous cobicistat and methods of its preparation. Cobicistat may be complexed with a pharmaceutically acceptable carrier such as β-cyclodextrin or hydroxy! propyl β-cyclodextrin. The present disclosure also provides pharmaceutical formulations for administration to patients and methods of their use.
Abstract translation: 本发明涉及无定形同位异构体的固体分散体及其制备方法。 Cobicistat可与药学上可接受的载体例如β-环糊精或羟基化合物络合。 丙基β-环糊精。 本公开还提供了用于给予患者的药物制剂及其使用方法。
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公开(公告)号：US20150299200A1
公开(公告)日：2015-10-22
申请号：US14652230
申请日：2013-12-16
Applicant: Bhausaheb CHAVHAN , Jebaraj RATHINAPANDIAN , Shiva Kumar CHANDUPTLA , Nagaraji GHANDA , MYLAN LABORATORIES LTD
Inventor： Bhausaheb CHAVHAN , Jebaraj RATHINAPANDIAN , Shiva Kumar CHANDUPTLA , Nagaraji GHANDA
IPC: C07D473/06
CPC classification number: C07D473/06 , C07D473/04
Abstract: The present invention relates to a process for preparing Linagliptin by purifying the intermediate compounds converting the purified intermediates into Linagliptin. The present invention also relates to the preparation of an amorphous Linagliptin.
Abstract translation: 本发明涉及通过纯化将纯化的中间体转化为临床药理学的中间体化合物来制备林格列汀的方法。 本发明还涉及无定形林格列汀的制备。
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Patent Agency Ranking
公开(公告)号：US09145365B2
公开(公告)日：2015-09-29
申请号：US14273270
申请日：2014-05-08
Applicant: MYLAN LABORATORIES LTD.
Inventor： Priyesh Vijaykar , Dattatrey Kokane , Sushant Gharat , Dhananjay Shinde , Manojkumar Bindu , Vinayak Gore
IPC: C07D213/75 , C07C45/64 , C07C51/29
CPC classification number: C07D213/75 , C07C45/64 , C07C51/29 , C07C2601/02 , C07C47/575 , C07C65/26
Abstract: The present invention relates to an improved process for the preparation of Roflumilast. The present invention also relates to crystalline Form-I of Roflumilast.
Abstract translation: 本发明涉及一种制备罗氟司特的改进方法。 本发明还涉及罗氟司特的结晶形式I。
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公开(公告)号：US20140350270A1
公开(公告)日：2014-11-27
申请号：US14363149
申请日：2012-12-05
Applicant: Mylan Laboratories LTD
IPC: C07D493/04
CPC classification number: C07D493/04
Abstract: The present invention relates to a non-solvated crystalline Darunavir, process for its preparation and pharmaceutical composition comprising it. The present invention also relates to a process for the preparation of amorphous Darunavir from a non-solvated crystalline Darunavir.
Abstract translation: 本发明涉及非溶剂化结晶达鲁那韦，其制备方法和包含其的药物组合物。 本发明还涉及从非溶剂化结晶的达鲁那韦制备无定形的达鲁那韦的方法。
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公开(公告)号：US10562866B2
公开(公告)日：2020-02-18
申请号：US15568550
申请日：2016-02-06
Applicant: Mylan Laboratories Ltd.
Inventor： Vellanki Sivaram Prasad , Arabinda Sahu , Siva Koteswara Rao Prathi , Lakshmana Rao Ampolu , Ramakoteswara Rao Jetti , Aggi Ramireddy Bommareddy , Neelima Bhagavatula , Nitin Ashok Shimpi
IPC: C07D257/04 , C07C231/12 , C07C231/24
Abstract: The amorphous form of trisodium sacubitril valsartan and methods for the preparation thereof are disclosed herein.
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9.发明申请公开(公告)号：US20180169245A1
公开(公告)日：2018-06-21
申请号：US15127612
申请日：2015-03-20
Applicant: MYLAN LABORATORIES LTD.
Inventor： Ramesh DANDALA , Sivarama Prasad VELLANKI , Raja Babu BALUSU , Subbarayudu PUTTA
IPC: A61K47/26 , A61K47/38 , A61K31/513 , A61K9/00
CPC classification number: A61K47/26 , A61K9/00 , A61K31/513 , A61K47/38 , A61P31/18 , C07B2200/13 , C07D413/12
Abstract: The present disclosure provides a process for the preparation a premix of raltegravir potassium form 3 with excipients. This premix may be used in the manufacture of pharmaceutical formulations containing raltegravir.
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公开(公告)号：US09902751B2
公开(公告)日：2018-02-27
申请号：US15105620
申请日：2014-12-29
Applicant: Mylan Laboratories Ltd.
IPC: C07H7/06 , C07H1/00 , C07H7/04 , C07H15/04 , C07D407/12 , C07H23/00 , C07D307/20
CPC classification number: C07H7/06 , C07D307/20 , C07D407/12 , C07H1/00 , C07H7/04 , C07H15/04 , C07H23/00 , Y02P20/55
Abstract: An improved process for the preparation of empagliflozin is disclosed. Novel intermediates of formulas (13) and (14) for the preparation of empagliflozin are also disclosed, wherein R1 and R2 are independently hydrogen or hydroxyl protecting groups.
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