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1.发明授权Use of pyruvate or succinate to enhance the efficacy of a hypoxia activated prodrug for the treatment of tumors 有权使用丙酮酸或琥珀酸盐来增强缺氧活化前体药物治疗肿瘤的功效公开(公告)号：US09402820B2
公开(公告)日：2016-08-02
申请号：US14112906
申请日：2012-04-20
IPC分类号： A61K31/19 , A61K45/06 , A61K31/355
CPC分类号： A61K31/19 , A61K31/355 , A61K45/06 , A61K2300/00
摘要： The identification of pO2 lowering agents as transient hypoxia-inducers is disclosed herein. Provided is a method of enhancing the efficacy of a hypoxia-sensitive agent in a subject, by administering to the subject a therapeutically effective amount of the hypoxia-sensitive agent and a therapeutically effective amount of a pO2 lowering agent. Methods of treating a subject with a tumor, by administering to the subject a therapeutically effective amount of a pO2 lowering agent and a therapeutically effective amount of a hypoxia-sensitive agent are also disclosed.
摘要翻译： 作为暂时缺氧诱导剂的pO2降低剂的鉴定在本文中公开。 本发明提供了一种通过向受试者施用治疗有效量的缺氧敏感剂和治疗有效量的pO2降低剂来增强受试者中缺氧敏感剂的功效的方法。 还公开了通过向受试者施用治疗有效量的pO2降低剂和治疗有效量的缺氧敏感剂来治疗患有肿瘤的受试者的方法。
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2.发明授权Nitroxide therapy for the treatment of von Hippel—Lindau disease (VHL) and renal clear cell carcinoma (RCC) 有权用于治疗von Hippel-Lindau病（VHL）和肾透明细胞癌（RCC）的硝酸处理公开(公告)号：US08853277B2
公开(公告)日：2014-10-07
申请号：US13512665
申请日：2010-11-30
IPC分类号： A61K31/13 , A61K31/40 , A61K31/445 , A61K31/421
CPC分类号： A61K31/40 , A61K31/421 , A61K31/445
摘要： The invention provides therapeutic methods that include administering a stable nitroxide to a subject that has, is suspected to have, or is at risk for having a condition associated with reduced VHL or elevated HIF-2α.
摘要翻译： 本发明提供了治疗方法，其包括向被怀疑具有或具有与降低的VHL或升高的HIF-2α相关的病症的风险的受试者施用稳定的氮氧自由基。
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3.发明授权公开(公告)号：US06573720B1
公开(公告)日：2003-06-03
申请号：US09424558
申请日：2000-04-10
申请人： Nallathamby Devasahayam , James B. Mitchell , Angelo Russo , John Cook , Mobae Afeworki , Rolf G. Tschudin , Sankaran Subramanian , Ramachandran Murugesan , Frank S. Harrington , Murali K. Cherukuri
发明人： Nallathamby Devasahayam , James B. Mitchell , Angelo Russo , John Cook , Mobae Afeworki , Rolf G. Tschudin , Sankaran Subramanian , Ramachandran Murugesan , Frank S. Harrington , Murali K. Cherukuri
IPC分类号： G01V300
CPC分类号： G01R33/3671 , G01R33/3415 , G01R33/60
摘要： A radiofrequency (RF) coil design, suitable for detecting time domain electron paramagnetic resonance (EPR) responses from spin probes after pulsed excitation using radiofrequency irradiation (60-400 MHz), is configured in an array of numerous surface coils of appropriate diameters connected in a parallel or axial configuration with appropriate spacing between individual surface coils to form a volume type resonator.
摘要翻译： 适用于检测使用射频辐射（60-400MHz）的脉冲激发之后的自旋探针的时域电子顺磁共振（EPR）响应的射频（RF）线圈设计被配置为以适当直径连接的许多表面线圈阵列 平行或轴向配置，在各个表面线圈之间具有适当的间隔，以形成体积型谐振器。
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4.发明申请FAST ELECTRON PARAMAGNETIC RESONANCE IMAGING (EPRI) IN THE CW EPR MODE USING RAPID-SCAN IN THE PRESENCE OF ROTATING GRADIENTS AND DIRECT DETECTION WITH TRANSMIT/RECEIVE & DATA PROCESSING IN A DIGITAL SIGNAL PROCESSING PLATFORM 有权在数字信号处理平台中通过发送/接收和数据处理在旋转梯度和直接检测中使用快速扫描的CW EPR模式中的快速电子参考共振成像（EPRI）公开(公告)号：US20110109313A1
公开(公告)日：2011-05-12
申请号：US12794695
申请日：2010-06-04
申请人： Sankaran Subramanian , Nallathamby Devasahayam , Janusz Koscielniak , James B. Mitchell , Murali K. Cherukuri
发明人： Sankaran Subramanian , Nallathamby Devasahayam , Janusz Koscielniak , James B. Mitchell , Murali K. Cherukuri
IPC分类号： G01R33/20
CPC分类号： G01R33/60
摘要： An electron paramagnetic resonance imaging system that includes means for continuously irradiating a sample with RF irradiation; means for imposing on the sample a sinusoidally varying magnetic field along with rotating gradients for spatial encoding; means for directly detecting signal data from the sample, without using field modulation, while irradiating the sample with RF radiation continuously, the means for directly detecting having means for sweeping the sinusoidally varying magnetic field; and means for transmitting, receiving and processing the signal data, using means including a digital signal processor.
摘要翻译： 一种电子顺磁共振成像系统，包括用于用RF照射连续照射样品的装置; 用于对样本施加正弦变化的磁场以及用于空间编码的旋转梯度的装置; 用于在不用场调制的情况下直接检测来自样品的信号数据的装置，同时用RF辐射连续照射样品，用于直接检测的装置具有用于扫描正弦变化磁场的装置; 以及用于使用包括数字信号处理器的装置发送，接收和处理信号数据的装置。
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公开(公告)号：US20140045796A1
公开(公告)日：2014-02-13
申请号：US14112906
申请日：2012-04-20
CPC分类号： A61K31/19 , A61K31/355 , A61K45/06 , A61K2300/00
摘要： The identification of pO2 lowering agents as transient hypoxia-inducers is disclosed herein. Provided is a method of enhancing the efficacy of a hypoxia-sensitive agent in a subject, by administering to the subject a therapeutically effective amount of the hypoxia-sensitive agent and a therapeutically effective amount of a pO2 lowering agent. Methods of treating a subject with a tumor, by administering to the subject a therapeutically effective amount of a pO2 lowering agent and a therapeutically effective amount of a hypoxia-sensitive agent are also disclosed.
摘要翻译： 作为暂时缺氧诱导剂的pO2降低剂的鉴定在本文中公开。 本发明提供了一种通过向受试者施用治疗有效量的缺氧敏感剂和治疗有效量的pO2降低剂来增强受试者中缺氧敏感剂的功效的方法。 还公开了通过向受试者施用治疗有效量的pO2降低剂和治疗有效量的缺氧敏感剂来治疗患有肿瘤的受试者的方法。
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公开(公告)号：US20090028798A1
公开(公告)日：2009-01-29
申请号：US11997236
申请日：2006-08-10
申请人： James B. Mitchell , Murali K. Cherukuri , John A. Cook , Fuminori Hyodo , Alan P. Koretsky , Ken-Ichiro Matsumoto , Sankaran Subramanian , David A. Wink
发明人： James B. Mitchell , Murali K. Cherukuri , John A. Cook , Fuminori Hyodo , Alan P. Koretsky , Ken-Ichiro Matsumoto , Sankaran Subramanian , David A. Wink
IPC分类号： A61K49/08
摘要： Disclosed is a method for determining the redox status of a region of interest in an animal tissue. The method includes administering a nitroxyl contrast agent to the region of interest, obtaining a magnetic resonance image of the region of interest, determining the amount of reduced nitroxyl contrast agent in the region of interest, and thereby determining the redox status of the region of interest.
摘要翻译： 公开了一种用于确定动物组织中感兴趣区域的氧化还原状态的方法。 该方法包括向感兴趣区域施用硝酰基造影剂，获得感兴趣区域的磁共振图像，确定感兴趣区域中还原的硝酰基造影剂的量，从而确定感兴趣区域的氧化还原状态 。
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7.发明申请NITROXIDE THERAPY FOR THE TREATMENT OF VON HIPPEL - LINDAU DISEASE (VHL) AND RENAL CLEAR CELL CARCINOMA (RCC) 有权治疗呕吐的硝基治疗 - 林达病（VHL）和肾细胞癌（RCC）公开(公告)号：US20120295937A1
公开(公告)日：2012-11-22
申请号：US13512665
申请日：2010-11-30
IPC分类号： A61K31/445 , A61P9/12 , A61P35/00
CPC分类号： A61K31/40 , A61K31/421 , A61K31/445
摘要： The invention provides therapeutic methods that include administering a stable nitroxide to a subject that has, is suspected to have, or is at risk for having a condition associated with reduced VHL or elevated HIF-2α.
摘要翻译： 本发明提供了治疗方法，其包括向被怀疑具有或具有与降低的VHL或升高的HIF-2α相关的病症的风险的受试者施用稳定的氮氧自由基。
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8.发明授权Fast electron paramagnetic resonance imaging (EPRI) in the CW EPR mode using rapid-scan in the presence of rotating gradients and direct detection with transmit/receive and data processing in a digital signal processing platform 有权快速电子顺磁共振成像（EPRI）在CW EPR模式下使用快速扫描存在旋转梯度，并在数字信号处理平台中进行发射/接收和数据处理的直接检测公开(公告)号：US08242778B2
公开(公告)日：2012-08-14
申请号：US12794695
申请日：2010-06-04
申请人： Sankaran Subramanian , Nallathamby Devasahayam , Janusz Koscielniak , James B. Mitchell , Murali K. Cherukuri
发明人： Sankaran Subramanian , Nallathamby Devasahayam , Janusz Koscielniak , James B. Mitchell , Murali K. Cherukuri
IPC分类号： G01V3/00
CPC分类号： G01R33/60
摘要： An electron paramagnetic resonance imaging system that includes means for continuously irradiating a sample with RF irradiation; means for imposing on the sample a sinusoidally varying magnetic field along with rotating gradients for spatial encoding; means for directly detecting signal data from the sample, without using field modulation, while irradiating the sample with RF radiation continuously, the means for directly detecting having means for sweeping the sinusoidally varying magnetic field; and means for transmitting, receiving and processing the signal data, using means including a digital signal processor.
摘要翻译： 一种电子顺磁共振成像系统，包括用于用RF照射连续照射样品的装置; 用于对样本施加正弦变化的磁场以及用于空间编码的旋转梯度的装置; 用于在不用场调制的情况下直接检测来自样品的信号数据的装置，同时用RF辐射连续照射样品，用于直接检测的装置具有用于扫描正弦变化磁场的装置; 以及用于使用包括数字信号处理器的装置发送，接收和处理信号数据的装置。
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9.发明授权In vivo imaging and oxymetry by pulsed radiofrequency paramagnetic resonance 失效通过脉冲射频顺磁共振进行体内成像和氧饱和度测定
公开(公告)号：US5865746A
公开(公告)日：1999-02-02
申请号：US902425
申请日：1997-07-29
申请人： Ramachandran Murugesan , Murali K. Cherukuri , James B. Mitchell , Sankaran Subramanian , Rolf G. Tschudin
发明人： Ramachandran Murugesan , Murali K. Cherukuri , James B. Mitchell , Sankaran Subramanian , Rolf G. Tschudin
CPC分类号： G01R33/60 , G01R33/3607 , G01R33/3621
摘要： A system for performing pulsed RF FT EPR spectroscopy and imaging includes an ultra-fast excitation subsystem and an ultra-fast data acquisition subsystem. Additionally, method for measuring and imaging in vivo oxygen and free radicals or for performing RF FT EPR spectroscopy utilizes short RF excitations pulses and ultra-fast sampling, digitizing, and summing steps.
摘要翻译： 用于执行脉冲RF FT EPR光谱和成像的系统包括超快速激发子系统和超快速数据采集子系统。 另外，用于测量和成像体内氧和自由基或进行RF FT EPR光谱的方法利用短RF激发脉冲和超快速采样，数字化和求和步骤。
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10.发明授权Gated RF preamplifier for use in pulsed radiofrequency electron paramagnetic resonance and MRI 失效用于脉冲射频电子顺磁共振和MRI的门控RF前置放大器
公开(公告)号：US5828216A
公开(公告)日：1998-10-27
申请号：US699383
申请日：1996-08-19
申请人： Rolf Gottfried Tschudin , Ramachandran Murugesan , Murali K. Cherukuri , James B. Mitchell , Sankaran Subramanian
发明人： Rolf Gottfried Tschudin , Ramachandran Murugesan , Murali K. Cherukuri , James B. Mitchell , Sankaran Subramanian
CPC分类号： G01R33/3621 , H03G1/0088 , G01R33/60
摘要： A gated RF preamplifier used in system for performing pulsed RF FT EPR spectroscopy and imaging or MRI. The RF preamplifier does not overload during a transmit cycle so that recovery is very fast to provide for ultra-fast data acquisition in an ultra-fast excitation subsystem. The preamplifier includes multiple low-gain amplification stages with high-speed RF gates inserted between stages that are switched off to prevent each stage from overloading during the transmit cycle.
摘要翻译： 用于执行脉冲RF FT EPR光谱和成像或MRI的系统中的门控RF前置放大器。 射频前置放大器在发射周期内不会过载，因此恢复非常快，以提供超快速激励子系统中的超快数据采集。 前置放大器包括多个低增益放大级，其中高速RF门插入在被切断的级之间，以防止每一级在发送周期期间发生过载。
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