公开(公告)号：US20070021323A1

公开(公告)日：2007-01-25

申请号：US11524753

申请日：2006-09-21

申请人： James Mitchell ,  Angelo Russo ,  Murali Cherukuri ,  Anne DeLuca

发明人： James Mitchell ,  Angelo Russo ,  Murali Cherukuri ,  Anne DeLuca

IPC分类号： A61K38/00 ,  A61K48/00 ,  A61K31/695 ,  A61K31/69 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/445 ,  A61K31/426 ,  A61K31/421 ,  A61K31/40

CPC分类号： A61K31/42 ,  A61K31/44 ,  A61K31/445

摘要： The present invention provides a method for the prophylactic and therapeutic treatment of cancer. The method comprises administering to an animal, preferably a mammal, more preferably a human, at risk for developing a cancer or having a cancer a nitroxide or a prodrug thereof, wherein the nitroxide or prodrug thereof preferably is alicyclic or heterocyclic and more preferably is a compound of Formula I or Formula II: in an amount sufficient to prevent or treat said cancer, wherein said cancer is susceptible to prevention or treatment by said nitroxide or prodrug thereof. Also provided is a composition for use in the method.

摘要翻译： 本发明提供了一种预防和治疗癌症的方法。 该方法包括给动物，优选哺乳动物，更优选人，其具有发展癌症或具有癌症的硝基氧或其前药的风险，其中所述氮氧自由基或其前药优选为脂环族或杂环基，更优选为 式I或式II化合物：足以预防或治疗所述癌症的量，其中所述癌症易于被所述氮氧化物或其前药预防或治疗。 还提供了用于该方法的组合物。

公开(公告)号：US5387867A

公开(公告)日：1995-02-07

申请号：US97811

申请日：1993-07-26

申请人： John Bourg ,  James Mitchell ,  Mark Mirotznik ,  Bradley Roth ,  Sankaran Subramanian ,  Murali Cherukuri ,  Paul G. Zablocky

发明人： John Bourg ,  James Mitchell ,  Mark Mirotznik ,  Bradley Roth ,  Sankaran Subramanian ,  Murali Cherukuri ,  Paul G. Zablocky

IPC分类号： G01R33/20 ,  A61B5/055 ,  G01N24/10 ,  G01R33/60

CPC分类号： G01R33/60

摘要： An EPR imager and spectrometer includes pulse generating system for generating broadband pulses having an RF carrier frequency that is not highly absorbed by biological samples. The pulse generating system includes up and down chirp convertors for frequency modulating a carrier frequency pulse and compressing the frequency modulated pulse to form a broadband excitation pulse of high energy. Such a machine could form the basis of a clinical imaging device capable of high sensitivity to free radical species in human patients.

摘要翻译： EPR成像器和光谱仪包括用于产生具有不被生物样品高度吸收的RF载波频率的宽带脉冲的脉冲发生系统。 脉冲发生系统包括用于频率调制载波频率脉冲的上和下啁啾转换器，并压缩频率调制脉冲以形成高能量的宽带激励脉冲。 这种机器可以形成能够对人类患者中的自由基物质具有高度敏感性的临床成像装置的基础。

公开(公告)号：US5502386A

公开(公告)日：1996-03-26

申请号：US340100

申请日：1994-11-15

申请人： John Bourg ,  James Mitchell ,  Mark Mirotznik ,  Bradley Roth ,  Sankaran Subramanian ,  Murali Cherukuri ,  Paul G. Zablocky ,  Thomas J. Pohida ,  Paul D. Smith ,  Walter S. Friauf ,  Rolf G. Tschudin

发明人： John Bourg ,  James Mitchell ,  Mark Mirotznik ,  Bradley Roth ,  Sankaran Subramanian ,  Murali Cherukuri ,  Paul G. Zablocky ,  Thomas J. Pohida ,  Paul D. Smith ,  Walter S. Friauf ,  Rolf G. Tschudin

IPC分类号： G01R33/20 ,  A61B5/055 ,  G01N24/10 ,  G01R33/60

CPC分类号： G01R33/60

摘要： An EPR imager and spectrometer includes pulse generating system for generating broadband pulses having an RF carrier frequency that is not highly absorbed by biological samples. The pulse generating system includes up and down chirp convertors for frequency modulating a carrier frequency pulse and compressing the frequency modulated pulse to form a broadband excitation pulse of high energy. Such a machine could form the basis of a clinical imaging device capable of high sensitivity to free radical species in human patients.