公开(公告)号：US20240216548A1

公开(公告)日：2024-07-04

申请号：US18425302

申请日：2024-01-29

申请人： Madeeha Shehzad Lodhi ,  Muhammad Tahir Khan ,  Shabbir Muhammad ,  H. Algarni ,  Tayyaba Yasin ,  Dong Qing Wei ,  Sharifah Mohammed Ali Al-Moayid

发明人： Madeeha Shehzad Lodhi ,  Muhammad Tahir Khan ,  Shabbir Muhammad ,  H. Algarni ,  Tayyaba Yasin ,  Dong Qing Wei ,  Sharifah Mohammed Ali Al-Moayid

IPC分类号： A61K49/00 ,  A61K36/58 ,  A61K47/12 ,  A61K47/18 ,  A61K47/69

CPC分类号： A61K49/0067 ,  A61K36/58 ,  A61K47/12 ,  A61K47/183 ,  A61K47/6929 ,  A61K49/0058 ,  A61K2236/33 ,  A61K2236/51

摘要： The method for preparing theragnostic carbon quantum dot nanomedicine composition comprises collecting and processing fresh plant samples of Azadirachta indica; mixing 50 g of crushed dried neem leaves powder with 500 mL of methanol and left to extract for 1 week; filtering the mixture and condensing using a rotary evaporator, and lyophilizing to obtain the extract; dissolving 0.57 g L-cysteine in 10 mL of deionized water and mixing with 1.5 g of citric acid to form a solution; ultrasonicating the solution for 10 minutes and then heating in a microwave oven for 4 minutes; cooling the solution to room temperature and then dissolving in 10 mL of deionized water to obtain a brown solution; centrifuging the brown solution at 9000 rpm for 10 minutes to remove impurities and filtering with a filter; and extracting the Carbon quantum dot (CQD) solution with ethyl acetate and storing in a refrigerator at 4° C.