公开(公告)号：US06512004B2

公开(公告)日：2003-01-28

申请号：US09900268

申请日：2001-07-06

申请人： Hong-jun Song ,  Mu-ming Poo ,  Guo-li Ming ,  Marc Tessier-Lavigne ,  Zhigang He

发明人： Hong-jun Song ,  Mu-ming Poo ,  Guo-li Ming ,  Marc Tessier-Lavigne ,  Zhigang He

IPC分类号： A61K3135

CPC分类号： A61K31/70

摘要： The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent protein kinase a neural cell subject to growth repulsion mediated by a neural cell growth repulsion factor. The activator may comprise a direct or an indirect activator of the protein kinase; the repulsion factor typically comprises one or more natural, endogenous proteins mediating localized repulsion or inhibition of neural cell growth; and the target cells are generally vertebrate neurons, typically injured mammalian neurons. The subject compositions include mixtures comprising a neural cell, an activator of a cyclic nucleotide dependent protein kinase and a neural cell growth repulsion factor.

公开(公告)号：US06268352B1

公开(公告)日：2001-07-31

申请号：US09145820

申请日：1998-09-02

申请人： Hong-jun Song ,  Mu-Ming Poo ,  Guo-li Ming ,  Marc Tessier-Lavigne ,  Zhigang He

发明人： Hong-jun Song ,  Mu-Ming Poo ,  Guo-li Ming ,  Marc Tessier-Lavigne ,  Zhigang He

IPC分类号： A61K3170

CPC分类号： A61K31/70

摘要： The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent protein kinase a neural cell subject to growth repulsion mediated by a neural cell growth repulsion factor. The activator may comprise a direct or an indirect activator of the protein kinase; the repulsion factor typically comprises one or more natural, endogenous proteins mediating localized repulsion or inhibition of neural cell growth; and the target cells are generally vertebrate neurons, typically injured mammalian neurons. The subject compositions include mixtures comprising a neural cell, an activator of a cyclic nucleotide dependent protein kinase and a neural cell growth repulsion factor.

摘要翻译： 本发明提供促进神经细胞生长和/或再生的方法和组合物。 一般方法包括与环核苷酸依赖性蛋白激酶的激活剂接触受到由神经细胞生长排斥因子介导的生长排斥的神经细胞的接触。 活化剂可以包含蛋白激酶的直接或间接激活剂; 排斥因子通常包含介导局部排斥或抑制神经细胞生长的一种或多种天然的内源性蛋白质; 并且靶细胞通常是脊椎动物神经元，通常是受损的哺乳动物神经元。 主题组合物包括包含神经细胞，环核苷酸依赖性蛋白激酶的激活剂和神经细胞生长排斥因子的混合物。