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公开(公告)号：US06797281B1
公开(公告)日：2004-09-28
申请号：US09958328
申请日：2001-10-09
申请人： Claudio Pisano , Maria Ornella Tinti , Mosé Santaniello , Luciana Critelli , Giovanni Salvatori
发明人： Claudio Pisano , Maria Ornella Tinti , Mosé Santaniello , Luciana Critelli , Giovanni Salvatori
IPC分类号： A61K9127
CPC分类号： C07C229/22 , A61K8/14 , A61K8/44 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K31/225 , A61K48/00 , A61Q19/00
摘要： Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the R groups are as defined in the description.
摘要翻译： 描述了左旋肉碱和烷酰基L-肉碱的酯，其可用作阳离子脂质用于药理学活性化合物的细胞内递送。 还公开了式（I）的L-肉碱和烷酰基L-肉毒碱的新酯，其中R基团如说明书中所定义。
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2.发明授权Esters of L-carnitine of alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds 失效用作阳离子脂质的烷酰基L-肉碱的左旋肉碱的酯用于细胞内递送药理学活性化合物公开(公告)号：US07629003B2
公开(公告)日：2009-12-08
申请号：US10624645
申请日：2003-07-23
申请人： Claudio Pisano , Maria Ornella Tinti , Mosé Santaniello , Luciana Critelli , Giovanni Salvatori
发明人： Claudio Pisano , Maria Ornella Tinti , Mosé Santaniello , Luciana Critelli , Giovanni Salvatori
IPC分类号： A61K9/127
CPC分类号： C07C229/22 , A61K8/14 , A61K8/44 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K31/225 , A61K48/00 , A61Q19/00
摘要： Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the R groups are as defined in the description.
摘要翻译： 描述了左旋肉碱和烷酰基L-肉碱的酯，其可用作阳离子脂质用于药理学活性化合物的细胞内递送。 还公开了式（I）的L-肉碱和烷酰基L-肉毒碱的新酯，其中R基团如说明书中所定义。
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3.发明授权Esters of L-carnitine or alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds 失效用作阳离子脂质用于细胞内递送药理活性化合物的左旋肉碱或烷酰基L-肉碱的酯公开(公告)号：US07585519B2
公开(公告)日：2009-09-08
申请号：US11727526
申请日：2007-03-27
申请人： Claudio Pisano , Maria Ornella Tinti , Mosé Santaniello , Luciana Critelli , Giovanni Salvatori
发明人： Claudio Pisano , Maria Ornella Tinti , Mosé Santaniello , Luciana Critelli , Giovanni Salvatori
IPC分类号： A61K9/127
CPC分类号： C07C229/22 , A61K8/14 , A61K8/44 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K31/225 , A61K48/00 , A61Q19/00
摘要： Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds. New esters of L-carnitine and alkanoyl L-carnitines of formula (I) are also disclosed wherein the R groups are as defined in the description.
摘要翻译： 描述了左旋肉碱和烷酰基L-肉碱的酯，其可用作阳离子脂质用于药理学活性化合物的细胞内递送。 还公开了式（I）的L-肉碱和烷酰基L-肉毒碱的新酯，其中R基团如说明书中所定义。
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4.发明授权Water-soluble salts of dodecandioic acid and pharmaceutical and nutritional compositions containing same 失效十二烷二酸的水溶性盐和含有它们的药物和营养组合物公开(公告)号：US06255503B1
公开(公告)日：2001-07-03
申请号：US09424252
申请日：1999-11-30
IPC分类号： C07C10100
CPC分类号： C07C229/26 , C07C55/21 , C07C215/40
摘要： Water-soluble dodecandioates wherein the cationic moiety is selected from the group comprising the cations of basic aminoacids (e.g. lysine) and choline and orally or parenterally administrable compositions containing same, are disclosed.
摘要翻译： 公开了水溶性十二烷二酸盐，其中阳离子部分选自碱性氨基酸（例如赖氨酸）和胆碱的阳离子和含有其的口服或非肠道给药组合物的组。
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