公开(公告)号：US5902885A

公开(公告)日：1999-05-11

申请号：US2513

申请日：1993-01-08

Applicant: Kunio Takanohashi ,  Mitsutaka Tanaka ,  Toru Yamano

Inventor： Kunio Takanohashi ,  Mitsutaka Tanaka ,  Toru Yamano

IPC: C07D307/62

CPC classification number: C07D307/62

Abstract: L-ascorbic acid is produced by allowing an acid to act on 2-keto-L-gulonic acid in a mixture solvent of an inert organic solvent and an aliphatic ketone in the presence of water and a surfactant.The method produces L-ascorbic acid in a high yield 90% or more and is an industrially advantageous method.

Abstract translation: 通过在水和表面活性剂的存在下，在惰性有机溶剂和脂族酮的混合溶剂中使酸作用于2-酮-L-古洛糖酸来制备L-抗坏血酸。 该方法以高产率生产L-抗坏血酸90％以上，是工业上有利的方法。

公开(公告)号：US5424478A

公开(公告)日：1995-06-13

申请号：US215813

申请日：1994-03-22

Applicant: Mitsutaka Tanaka ,  Tadashi Hanaoka ,  Kunio Takanohashi

Inventor： Mitsutaka Tanaka ,  Tadashi Hanaoka ,  Kunio Takanohashi

IPC: C07C69/07 ,  C07C403/12

CPC classification number: C07C403/12 ,  C07C2101/16

Abstract: The present specification relates to an industrially advantageous process for producing vitamin A derivatives which are useful as medicaments, feed additives, food additives and the like. The process provides vitamin A derivatives, particularly all-trans vitamin A derivatives in high yield and purity.

Abstract translation: 本说明书涉及可用作药物，饲料添加剂，食品添加剂等的维生素A衍生物的工业上有利的方法。 该方法以高产率和纯度提供维生素A衍生物，特别是全反式维生素A衍生物。

公开(公告)号：US4845246A

公开(公告)日：1989-07-04

申请号：US205094

申请日：1988-06-10

Applicant: Kunio Takanohashi ,  Mitsutaka Tanaka ,  Toru Yamano

Inventor： Kunio Takanohashi ,  Mitsutaka Tanaka ,  Toru Yamano

IPC: C07H7/06

CPC classification number: C07H7/06

Abstract: 6-O-(2-keto-L-gulonoyl)-L-ascorbate substantially free from 2-keto-L-gulonic acid is produced by allowing an acid to act on 2-keto-L-gulonic acid in an inert organic solvent and recovering 6-O-(2-keto-L-gulonoyl)-L-ascorbate from the reaction mixture.6-O-(2-keto-L-gulonoyl)-L-ascorbate is more fat-soluble than L-ascorbic acid and is expected of the use as a prodrug for L-ascorbic acid that can be absorbed from the intestinal tract.

公开(公告)号：US4794182A

公开(公告)日：1988-12-27

申请号：US073697

申请日：1987-07-14

Applicant: Kunio Takanohashi ,  Toru Yamano ,  Mitsutaka Tanaka

Inventor： Kunio Takanohashi ,  Toru Yamano ,  Mitsutaka Tanaka

IPC: C07D239/42

CPC classification number: C07D239/42

Abstract: A novel 2-lower alkyl-4-amino-5-substituted iminopyrimidine compound represented by the formula: ##STR1## wherein R is a lower alkyl, and Y is hydroxyl or amino which may be protected or a salt thereof is obtainable by allowing a formylpyrimidine compound represented by the formula: ##STR2## wherein R is a lower alkyl to react with a compound represented by the formula H.sub.2 N--Y, wherein Y is hydroxyl or amino which may be protected, or a salts thereof. The iminopyrimidine compound gives the known pyrimidine compound represented by the formula: ##STR3## wherein R is as defined above in high yield. Therefor, the process is very useful as an industrial production method.

Abstract translation: 由下式表示的新型2-低级烷基-4-氨基-5-取代的亚氨基嘧啶化合物：其中R为低级烷基，Y为可被保护的羟基或氨基或其盐可通过使 由下式表示的甲酰嘧啶化合物：其中R是与式H2N-Y表示的化合物反应的低级烷基，其中Y是可被保护的羟基或氨基，或其盐。 亚氨基嘧啶化合物以高产率得到由下式表示的已知嘧啶化合物：其中R如上定义。 因此，该方法作为工业生产方法是非常有用的。