IMPLANTABLE BIOARTIFICIAL PERFUSION SYSTEM
    2.
    发明申请
    IMPLANTABLE BIOARTIFICIAL PERFUSION SYSTEM 审中-公开
    可植物生物灌注系统

    公开(公告)号:US20150297828A1

    公开(公告)日:2015-10-22

    申请号:US14753554

    申请日:2015-06-29

    IPC分类号: A61M5/142 A61F2/02

    摘要: The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immuno-rejection of the host body or of the host to the secretory cells.

    摘要翻译: 本公开提供了一种植入式生物人工活性分泌系统,用于提供生理调节分泌物,例如生理活性的功能性,例如活体宿主的葡萄糖代谢所必需的胰岛素。 该系统包括可植入主机内的壳体,其与组织液体流体连通,指示生理调节分泌需要。 壳体内的室包含多个生理活性的,自主功能的活的分泌细胞,用于产生生理调节分泌物。 连续操作的两个泵装置使组织液与分泌细胞接触,以吸收生理调节分泌物,用于随后的生理有效分配到宿主中,同时避免宿主体或宿主对分泌细胞的免疫排斥 。

    Implantable bioartificial perfusion system
    3.
    发明授权
    Implantable bioartificial perfusion system 有权
    植入式生物人工灌注系统

    公开(公告)号:US09101707B2

    公开(公告)日:2015-08-11

    申请号:US13835655

    申请日:2013-03-15

    IPC分类号: A61M5/142 A61F2/02 A61M5/145

    摘要: The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immunorejection of the host body or of the host to the secretory cells.

    摘要翻译: 本公开提供了一种植入式生物人工活性分泌系统,用于提供生理调节分泌物,例如生理活性的功能性,例如活体宿主的葡萄糖代谢所必需的胰岛素。 该系统包括可植入主机内的壳体,其与组织液体流体连通,指示生理调节分泌需要。 壳体内的室包含多个生理活性的,自主功能的活的分泌细胞,用于产生生理调节分泌物。 连续操作的两个泵装置使组织液与分泌细胞接触,以拾取生理调节分泌物,以便随后生理上有效地分配到宿主中,同时避免宿主体或宿主免疫分泌到分泌细胞。

    IMPLANTABLE BIOARTIFICIAL PERFUSION SYSTEM
    4.
    发明申请
    IMPLANTABLE BIOARTIFICIAL PERFUSION SYSTEM 审中-公开
    可植物生物灌注系统

    公开(公告)号:US20130289540A1

    公开(公告)日:2013-10-31

    申请号:US13835655

    申请日:2013-03-15

    IPC分类号: A61M5/142

    摘要: The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immunorejection of the host body or of the host to the secretory cells.

    摘要翻译: 本公开提供了一种植入式生物人工活性分泌系统,用于提供生理调节分泌物,例如生理活性的功能性,例如活体宿主的葡萄糖代谢所必需的胰岛素。 该系统包括可植入主机内的壳体,其与组织液体流体连通,指示生理调节分泌需要。 壳体内的室包含多个生理活性的,自主功能的活的分泌细胞,用于产生生理调节分泌物。 连续操作的两个泵装置使组织液与分泌细胞接触,以拾取生理调节分泌物,以便随后生理上有效地分配到宿主中,同时避免宿主体或宿主免疫分泌到分泌细胞。