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公开(公告)号：US09814829B2
公开(公告)日：2017-11-14
申请号：US14753554
申请日：2015-06-29
申请人： Gregory Zeltser , Michael Piliavin
发明人： Gregory Zeltser , Michael Piliavin
CPC分类号： A61M5/14276 , A61F2/022 , A61M1/28 , A61M2005/14513 , A61M2202/0007 , A61M2205/04 , A61M2205/18 , A61M2205/3303 , A61M2205/3523 , A61M2210/1021
摘要： The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immuno-rejection of the host body or of the host to the secretory cells.
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公开(公告)号：US20150297828A1
公开(公告)日：2015-10-22
申请号：US14753554
申请日：2015-06-29
申请人： Gregory ZELTSER , Michael PILIAVIN
发明人： Gregory ZELTSER , Michael PILIAVIN
CPC分类号： A61M5/14276 , A61F2/022 , A61M1/28 , A61M2005/14513 , A61M2202/0007 , A61M2205/04 , A61M2205/18 , A61M2205/3303 , A61M2205/3523 , A61M2210/1021
摘要： The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immuno-rejection of the host body or of the host to the secretory cells.
摘要翻译： 本公开提供了一种植入式生物人工活性分泌系统，用于提供生理调节分泌物，例如生理活性的功能性，例如活体宿主的葡萄糖代谢所必需的胰岛素。 该系统包括可植入主机内的壳体，其与组织液体流体连通，指示生理调节分泌需要。 壳体内的室包含多个生理活性的，自主功能的活的分泌细胞，用于产生生理调节分泌物。 连续操作的两个泵装置使组织液与分泌细胞接触，以吸收生理调节分泌物，用于随后的生理有效分配到宿主中，同时避免宿主体或宿主对分泌细胞的免疫排斥 。
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公开(公告)号：US09101707B2
公开(公告)日：2015-08-11
申请号：US13835655
申请日：2013-03-15
申请人： Gregory Zeltser , Michael Piliavin
发明人： Gregory Zeltser , Michael Piliavin
CPC分类号： A61M5/14276 , A61F2/022 , A61M1/28 , A61M2005/14513 , A61M2202/0007 , A61M2205/04 , A61M2205/18 , A61M2205/3303 , A61M2205/3523 , A61M2210/1021
摘要： The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immunorejection of the host body or of the host to the secretory cells.
摘要翻译： 本公开提供了一种植入式生物人工活性分泌系统，用于提供生理调节分泌物，例如生理活性的功能性，例如活体宿主的葡萄糖代谢所必需的胰岛素。 该系统包括可植入主机内的壳体，其与组织液体流体连通，指示生理调节分泌需要。 壳体内的室包含多个生理活性的，自主功能的活的分泌细胞，用于产生生理调节分泌物。 连续操作的两个泵装置使组织液与分泌细胞接触，以拾取生理调节分泌物，以便随后生理上有效地分配到宿主中，同时避免宿主体或宿主免疫分泌到分泌细胞。
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公开(公告)号：US20130289540A1
公开(公告)日：2013-10-31
申请号：US13835655
申请日：2013-03-15
申请人： Gregory Zeltser , Michael Piliavin
发明人： Gregory Zeltser , Michael Piliavin
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61F2/022 , A61M1/28 , A61M2005/14513 , A61M2202/0007 , A61M2205/04 , A61M2205/18 , A61M2205/3303 , A61M2205/3523 , A61M2210/1021
摘要： The disclosure provides an implantable bioartificial active secretion system for providing a physiological regulating secretion such as insulin necessary for functionality of a physiologic activity such as glucose metabolism of a living-being host. The system includes a housing implantable within the host, in fluidic communication with tissue fluid indicative of a physiological regulating secretion need. A chamber within the housing contains a plurality of physiologically active, autonomously functioning, live secretory cells for producing the physiological regulating secretion. A continually operating two pump apparatus moves tissue fluid into contact with the secretory cells for pick up of the physiological regulating secretion for subsequent physiologically-effective dispensing into the host, while avoiding immunorejection of the host body or of the host to the secretory cells.
摘要翻译： 本公开提供了一种植入式生物人工活性分泌系统，用于提供生理调节分泌物，例如生理活性的功能性，例如活体宿主的葡萄糖代谢所必需的胰岛素。 该系统包括可植入主机内的壳体，其与组织液体流体连通，指示生理调节分泌需要。 壳体内的室包含多个生理活性的，自主功能的活的分泌细胞，用于产生生理调节分泌物。 连续操作的两个泵装置使组织液与分泌细胞接触，以拾取生理调节分泌物，以便随后生理上有效地分配到宿主中，同时避免宿主体或宿主免疫分泌到分泌细胞。
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