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    Substituted 4-phenylpiperidines, their preparation and use
    3.
    发明授权
    Substituted 4-phenylpiperidines, their preparation and use 有权
    取代的4-苯基哌啶，其制备和用途

    公开(公告)号：US09434727B2

    公开(公告)日：2016-09-06

    申请号：US14699672

    申请日：2015-04-29

    申请人： Konstantin Petrukhin ,  Christopher Cioffi ,  Graham Johnson ,  Rando Allikmets ,  Emily Freeman ,  Ping Chen ,  Michael Conlon ,  Lei Zhu

    发明人： Konstantin Petrukhin ,  Christopher Cioffi ,  Graham Johnson ,  Rando Allikmets ,  Emily Freeman ,  Ping Chen ,  Michael Conlon ,  Lei Zhu

    IPC分类号： C07D211/06 ,  C07D295/00 ,  C07D471/04 ,  C07D487/04

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供具有以下结构的化合物：其中R 1，R 2，R 3，R 4和R 5各自独立地为H，卤素，CF 3或C 1 -C 4烷基，其中R 1，R 2，R 3，R 4或R 5中的两个或多个 不是H; R6是H，OH或卤素; B是取代或未取代的杂双环，其中当R1是CF3时，R2是H，R3是F，R4是H，R5是H，或R1是H，R2是CF3，R3是H，R4是CF3， R5是H，或R1是Cl，R2是H，R3是H，R4是F，R5是H，或R1是CF3，R2是H，R3是F，R4是H，R5是H，或R1 为CF 3，R 2为F，R 3为H，R 4为H，R 5为H或R 1为Cl，R 2为F，R 3为H，R 4为H，R 5为H，则B为 其可接受的盐。

    SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE
    4.
    发明申请
    SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE 有权
    取代的4-苯基哌啶，其制备和使用

    公开(公告)号：US20150315197A1

    公开(公告)日：2015-11-05

    申请号：US14699672

    申请日：2015-04-29

    申请人： Konstantin PETRUKHIN ,  Christopher CIOFFI ,  Graham JOHNSON ,  Rando ALLIKMETS ,  Emily FREEMAN ,  Ping CHEN ,  Michael CONLON ,  Lei ZHU

    发明人： Konstantin PETRUKHIN ,  Christopher CIOFFI ,  Graham JOHNSON ,  Rando ALLIKMETS ,  Emily FREEMAN ,  Ping CHEN ,  Michael CONLON ,  Lei ZHU

    IPC分类号： C07D487/04 ,  C07D471/04

    CPC分类号： C07D487/04 ,  C07D471/04

    摘要： The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明提供具有以下结构的化合物：其中R 1，R 2，R 3，R 4和R 5各自独立地为H，卤素，CF 3或C 1 -C 4烷基，其中R 1，R 2，R 3，R 4或R 5中的两个或多个 不是H; R6是H，OH或卤素; B是取代或未取代的杂双环，其中当R1是CF3时，R2是H，R3是F，R4是H，R5是H，或R1是H，R2是CF3，R3是H，R4是CF3， R5是H，或R1是Cl，R2是H，R3是H，R4是F，R5是H，或R1是CF3，R2是H，R3是F，R4是H，R5是H，或R1 为CF 3，R 2为F，R 3为H，R 4为H，R 5为H或R 1为Cl，R 2为F，R 3为H，R 4为H，R 5为H，B为 其可接受的盐。