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    Memno peptides, process for their preparation and use thereof
    3.
    发明授权
    Memno peptides, process for their preparation and use thereof 有权
    Memno肽，其制备方法和用途

    公开(公告)号：US06627604B2

    公开(公告)日：2003-09-30

    申请号：US09794346

    申请日：2001-02-28

    Applicant: Laszlo Vertesy ,  Herbert Kogler ,  Astrid Markus ,  Matthias Schiell

    Inventor： Laszlo Vertesy ,  Herbert Kogler ,  Astrid Markus ,  Matthias Schiell

    IPC: A61K3808

    CPC classification number: C07K7/06 ,  A61K38/00

    Abstract: The invention relates to novel peptide derivatives, called memno peptides, of the formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8 and (A)n have the meaning herein, obtainable by cultivation of Memnoniella echinata FH2272, DSM 13195 or mutants and variants of this, a process for their preparation and the use of the compounds as pharmaceuticals, for example against cardiac insufficiency.

    Abstract translation: 本发明涉及式（I）所示的新型肽衍生物（称为memno肽）：其中R1，R2，R3，R4，R5，R6，R7，R8和（A）n具有本文的含义，可通过培养Memnoniella echinata FH2272，DSM 13195或其突变体和变体，其制备方法和化合物用作药物的方法，例如针对心脏功能不全。

    Cephaibols: novel antiparasitics from Acremonium tubakii, process for their production, and use thereof
    4.
    发明授权
    Cephaibols: novel antiparasitics from Acremonium tubakii, process for their production, and use thereof 有权
    头孢唑醇：来自Acremonium tubakii的新型抗寄生虫药，其生产方法及其用途

    公开(公告)号：US07067112B2

    公开(公告)日：2006-06-27

    申请号：US10411144

    申请日：2003-04-11

    Applicant: Laszlo Vertesy ,  Michael Kurz ,  Matthias Schiell ,  Joachim Hofmann

    Inventor： Laszlo Vertesy ,  Michael Kurz ,  Matthias Schiell ,  Joachim Hofmann

    IPC: A61K49/00 ,  A61K38/10 ,  C07K7/08

    CPC classification number: C07K7/08 ,  A61K38/00

    Abstract: The invention relates to compounds of the formula I AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R   (I) in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are Iva; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II AcPhe-Iva-Gln-Aib-lle-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser,   (II) wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.

    Abstract translation: 本发明涉及式I化合物<？in-line-formula description =“In-line Formulas”end =“lead”→AcPhe-Aib-Aib-Aib-xw-Leu-y-Aib-Hyp-Gln -z-Hyp-Aib-Pro-R（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R是Phe-ol或Phe-al，w，x ，y和z具有以下含义：a）w是Gly或Ala; x是Aib，y和z是Iva; b）w是Gly; x，y和z是Iva; c）w是Gly; x和z是Aib，y是Iva; d）w是Gly; x，y和z是Aib; 或e）w是Gly; x和y是Aib，z是Iva; AcPhe-Iva-Gln-Aib-Lle-Thr-Aib-Leu-Aib-x-Gln-Aib，或者式II <？in-line-formula description =“In-line Formulas”end =“lead” -Hyp-Aib-Pro-Phe-Ser，（II）<？在线公式描述=“在线公式”end =“tail”？>其中x是Hyp或Pro，它们是由Acremonium tubakii FH 1685 DSM 12774在发酵过程中释放到培养基中，从培养基中分离头孢胆素的方法及其纯化，以及将头孢唑醇用作药物活性化合物，特别是用于控制寄生虫的方法。

    Cephaibols: novel antiparasitics from Acremonium tubakii process for their production, and use thereof
    5.
    发明授权
    Cephaibols: novel antiparasitics from Acremonium tubakii process for their production, and use thereof 有权
    Cephaibols：来自Acremonium tubakii方法的新型抗寄生虫药物的生产及其用途

    公开(公告)号：US06582949B1

    公开(公告)日：2003-06-24

    申请号：US09563505

    申请日：2000-05-03

    Applicant: László Vértesy ,  Michael Kurz ,  Matthias Schiell ,  Joachim Hofmann

    Inventor： László Vértesy ,  Michael Kurz ,  Matthias Schiell ,  Joachim Hofmann

    IPC: C07K708

    CPC classification number: C07K7/08 ,  A61K38/00

    Abstract: The invention relates to compounds of the formula I AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R  (I) in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are va; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II AcPhe-Iva-Gln-Aib-Ile-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser  (II), wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.

    Abstract translation: 本发明涉及式Iin化合物，其中R为Phe-ol或Phe-al，w，x，y和z具有以下含义：a）w为Gly或Ala; x是Aib，y和z是Iva; b）w是Gly; x，y和z是va; c）w是Gly; x和z是Aib，y是Iva; d）w是Gly; x，y和z是Aib; 矿石）w是Gly; x和y是Aib，z是Iva;或者其中X是Hyp或Pro的式II，其在发酵过程中被Acremonium tubakii FH 1685 DSM 12774合成并释放到培养基中，从头孢曲松 培养基和它们的纯化，以及将头孢吡肟作为药理学活性化合物的用途，特别是用于控制寄生虫。

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