公开(公告)号：US20110319463A1

公开(公告)日：2011-12-29

申请号：US13255563

申请日：2010-03-10

Applicant: Masaaki Sasaoka ,  Tomoko Umemoto ,  Hisayuki Seike ,  Masaaki Kageyama

Inventor： Masaaki Sasaoka ,  Tomoko Umemoto ,  Hisayuki Seike ,  Masaaki Kageyama

IPC: A61K31/405 ,  A61P27/02 ,  A61P27/06 ,  A61K31/4045

CPC classification number: C07D209/42 ,  A61K31/405 ,  C07D403/06

Abstract: A method for preventing or treating an optic nerve disorder, inhibiting retinal nerve cell death or recovering a neurofilament light chain expression level by administering to a patient a pharmacologically effective amount of at least one of the compound represented by the following formula (1): wherein R1 is a hydrogen atom or a lower alkyl group R2 is a hydrogen atom or a lower alkyl group; R1 and R2 may be joined to each other to form an aziridine ring, an azetidine ring, a pyrrolidine ring, a piperidine ring or an azepane ring; and R3 is a carboxyl group or an ester thereof or an amide thereof; or a salt thereof.

Abstract translation: 一种通过向患者施用药理学有效量的由下式（1）表示的化合物中的至少一种的方法，其用于预防或治疗视神经障碍，抑制视网膜神经细胞死亡或恢复神经丝轻链表达水平：其中 R1是氢原子或低级烷基R2是氢原子或低级烷基; R 1和R 2可以彼此连接形成氮丙啶环，氮杂环丁烷环，吡咯烷环，哌啶环或氮杂环。 并且R 3是羧基或其酯或其酰胺; 或其盐。

公开(公告)号：US20080075760A1

公开(公告)日：2008-03-27

申请号：US11679624

申请日：2007-02-27

Applicant: Shinji Suzuki ,  Noriyasu Ike ,  Kiyotsugu Sawamura ,  Hiromu Matsumoto ,  Eri Tamura ,  Jun Morisawa ,  Hiroto Takiguchi ,  Masaaki Ariyoshi ,  Kenji Taniguchi ,  Hideaki Yoshida ,  Hitoshi Tsuruta ,  Masaaki Sasaoka ,  Akihiro Sasaki

Inventor： Shinji Suzuki ,  Noriyasu Ike ,  Kiyotsugu Sawamura ,  Hiromu Matsumoto ,  Eri Tamura ,  Jun Morisawa ,  Hiroto Takiguchi ,  Masaaki Ariyoshi ,  Kenji Taniguchi ,  Hideaki Yoshida ,  Hitoshi Tsuruta ,  Masaaki Sasaoka ,  Akihiro Sasaki

IPC: A61K9/70 ,  B32B27/04

CPC classification number: A61K8/0208 ,  A61K8/345 ,  A61Q19/00 ,  A61Q19/007 ,  D04H1/425 ,  D04H1/4258 ,  D04H1/4291 ,  D04H1/435 ,  D04H1/4382 ,  D04H1/492 ,  Y10T442/2525

Abstract: The moisturized nonwoven fabric of the invention contains 1% or more of a water-soluble component to a weight of a pre-moisturized nonwoven fabric and an increase ratio of an equilibrium moisture regain (equilibrium water content) is 0.5% or more as compared with an equilibrium moisture regain of the moisturized nonwoven fabric after the water-soluble component is removed. Therefore, this moisturized nonwoven fabric is excellent in use feel such as skin touch and wiping property and functionalities such as water absorption property and water retention property. Further, this moisturized nonwoven fabric is excellent in functionalities such as moisturizing liquid transferring capability and skin moisturizing effect.

Abstract translation: 本发明的保湿无纺布含有1质量％以上的水溶性成分与预保湿无纺布的重量相比，平衡回潮率（平衡含水量）的增加比例为0.5％以上，与 除去水溶性成分后的保湿无纺布的平衡回潮。 因此，该保湿无纺布的使用感如皮肤触感和擦拭性以及吸水性和保水性等功能性优异。 此外，该保湿无纺布的功能性优异，例如保湿液输送能力和皮肤保湿效果。

公开(公告)号：US20110009376A1

公开(公告)日：2011-01-13

申请号：US12919462

申请日：2009-02-27

Applicant: Shin-ichiro Hirai ,  Masaaki Sasaoka ,  Hisayuki Seike

Inventor： Shin-ichiro Hirai ,  Masaaki Sasaoka ,  Hisayuki Seike

IPC: A61K31/555 ,  A61P27/02

CPC classification number: A61K9/0048 ,  A61K9/0019 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2059 ,  C07D293/10

Abstract: The present invention provides a novel pharmaceutical use of 2-phenyl-1,2-benzisoselenazol-3(2H)-one or a salt thereof. 2-Phenyl-1,2-benzisoselenazol-3(2H)-one or a salt thereof exhibits an excellent suppressive effect on retinal ganglion cell death in a pharmacological test using rats, and is therefore useful as a prophylactic or therapeutic agent for an eye disease accompanied by optic nerve disorder.

Abstract translation: 本发明提供2-苯基-1,2-苯并异硒唑（3H） - 酮或其盐的新药用途。 2-苯基-1,2-苯并异硒唑-3（2H）酮或其盐在使用大鼠的药理学试验中对视网膜神经节细胞死亡显示出优异的抑制作用，因此可用作眼睛的预防或治疗剂 伴有视神经障碍的疾病。

公开(公告)号：US07422326B2

公开(公告)日：2008-09-09

申请号：US10483318

申请日：2002-07-03

Applicant: Katsuki Nakamura ,  Masaaki Sasaoka

Inventor： Katsuki Nakamura ,  Masaaki Sasaoka

IPC: A61B3/14

CPC classification number: A61B3/0083 ,  A61B3/024 ,  A61B2503/40

Abstract: The present invention relates to a system and a method for determining a field of a vision of a monkey. Its object is to provide a system and a method which can cause a monkey to effect accurate visual field determination like a human subject. To achieve the object, according to the invention, there is provided a system for determining visual field of a monkey, comprising: a head fixing unit (A) for fixing a chair (1) to be seated by the monkey and the monkey's head; an eye target display unit (B) for displaying a gazing point (2) at which the monkey is caused to fix its eye and displaying also an eye target (3) at a predetermined position within the monkey's visual field with a predetermined brightness; a gazing monitor unit (C) for monitoring the direction of the monkey's gazing; and a response lever (4) by which the monkey shows that it has recognized the eye target; wherein the head fixing unit (A) includes an attachment member (5) fixable to the top of the monkey's head, a support member (6) connectable to the attachment member (5), and a base member (7) for fixing the support member (6). There is also provided a method for determining a visual field of a monkey using this system.

Abstract translation: 本发明涉及一种用于确定猴子的视野的系统和方法。 其目的是提供一种系统和方法，其可以使猴子像人类受试者一样进行精确的视野确定。 为了实现该目的，根据本发明，提供了一种用于确定猴子的视野的系统，包括：头部固定单元（A），用于固定由猴子和猴子头部坐下的椅子（1）; 用于显示使猴子固定眼睛的注视点（2）的眼目标显示单元（B），并且以预定的亮度还将眼目标（3）显示在猴的视野内的预定位置; 用于监视猴子注视方向的注视监视器单元（C）; 和响应杆（4），猴子显示它已经识别了眼睛目标; 其特征在于，所述头固定单元（A）包括可固定到所述猴头顶部的附接构件（5），可连接到所述附接构件（5）的支撑构件（6）和用于固定所述支撑件 会员（6）。 还提供了一种使用该系统确定猴子的视野的方法。

公开(公告)号：US20060232742A1

公开(公告)日：2006-10-19

申请号：US10483318

申请日：2002-07-03

Applicant: Katsuki Nakamura ,  Masaaki Sasaoka

Inventor： Katsuki Nakamura ,  Masaaki Sasaoka

IPC: A61B3/00

CPC classification number: A61B3/0083 ,  A61B3/024 ,  A61B2503/40

Abstract: The present invention relates to a system and a method for determining a field of a vision of a monkey. Its object is to provide a system and a method which can cause a monkey to effect accurate visual field determination like a human subject. To achieve the object, according to the invention, there is provided a system for determining visual field of a monkey, comprising: a head fixing unit (A) for fixing a chair (1) to be seated by the monkey and the monkey's head; an eye target display unit (B) for displaying a gazing point (2) at which the monkey is caused to fix its eye and displaying also an eye target (3) at a predetermined position within the monkey's visual field with a predetermined brightness; a gazing monitor unit (C) for monitoring the direction of the monkey's gazing; and a response lever (4) by which the monkey shows that it has recognized the eye target; wherein the head fixing unit (A) includes an attachment member (5) fixable to the top of the monkey's head, a support member (6) connectable to the attachment member (5), and a base member (7) for fixing the support member (6). There is also provided a method for determining a visual field of a monkey using this system.

Abstract translation: 本发明涉及一种用于确定猴子的视野的系统和方法。 其目的是提供一种系统和方法，其可以使猴子像人类受试者一样进行精确的视野确定。 为了实现该目的，根据本发明，提供了一种用于确定猴子的视野的系统，包括：头部固定单元（A），用于固定由猴子和猴子头部坐下的椅子（1）; 用于显示使猴子固定眼睛的注视点（2）的眼目标显示单元（B），并且以预定的亮度还将眼目标（3）显示在猴的视野内的预定位置; 用于监视猴子注视方向的注视监视器单元（C）; 和响应杆（4），猴子显示它已经识别了眼睛目标; 其特征在于，所述头固定单元（A）包括可固定到所述猴头顶部的附接构件（5），可连接到所述附接构件（5）的支撑构件（6）和用于固定所述支撑件 会员（6）。 还提供了一种使用该系统确定猴子的视野的方法。