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1.发明授权公开(公告)号：US11857541B2
公开(公告)日：2024-01-02
申请号：US16916145
申请日：2020-06-30
IPC分类号： A61K31/436 , A61K31/4545 , A61K9/00 , A61K9/20 , A61K45/06 , A61K31/22 , A61K31/675 , A61K31/55 , A61K31/663
CPC分类号： A61K31/436 , A61K9/0053 , A61K9/20 , A61K31/22 , A61K31/4545 , A61K31/675 , A61K45/06 , A61K31/55 , A61K31/663 , A61K31/22 , A61K2300/00 , A61K31/675 , A61K2300/00 , A61K31/4545 , A61K2300/00 , A61K31/436 , A61K2300/00
摘要： Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin and increase progerin clearance.
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2.发明申请公开(公告)号：US20200330443A1
公开(公告)日：2020-10-22
申请号：US16916145
申请日：2020-06-30
IPC分类号： A61K31/436 , A61K31/4545 , A61K9/00 , A61K9/20 , A61K45/06 , A61K31/22 , A61K31/675
摘要： Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin and increase progerin clearance.
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3.发明申请COMBINATION THERAPIES FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING, AND ATHEROSCLEROSIS 有权治疗肌瘤，细胞衰老和甲状腺功能亢进的联合治疗公开(公告)号：US20140274964A1
公开(公告)日：2014-09-18
申请号：US14209197
申请日：2014-03-13
IPC分类号： A61K31/675 , A61K31/22 , A61K31/436 , A61K31/4545
CPC分类号： A61K31/675 , A61K31/22 , A61K31/436 , A61K31/4545 , A61K31/55 , A61K31/663 , A61K45/06 , A61K2300/00
摘要： Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin, and inhibit farnesyl biosynthesis, lamin A prenylation, and increase progerin clearance.
摘要翻译： 本文提供了用于治疗原型疾病和病症，细胞衰老，骨疾病和心血管疾病的组合疗法。 所提供的组合疗法针对突变型蛋白质A蛋白progerin的异常法呢基化，并且抑制法呢基生物合成，层析蛋白A异戊烯基化，并增加progerin清除率。
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4.发明授权Combination therapies for treatment of laminopathies, cellular aging, and atherosclerosis 有权用于治疗薄层病，细胞衰老和动脉粥样硬化的联合疗法公开(公告)号：US09381203B2
公开(公告)日：2016-07-05
申请号：US14209197
申请日：2014-03-13
IPC分类号： A61K31/44 , A61K31/675 , A61K31/21 , A61K31/4545 , A61K31/22 , A61K31/436 , A61K45/06 , A61K31/55 , A61K31/663
CPC分类号： A61K31/675 , A61K31/22 , A61K31/436 , A61K31/4545 , A61K31/55 , A61K31/663 , A61K45/06 , A61K2300/00
摘要： Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin, and inhibit farnesyl biosynthesis, lamin A prenylation, and increase progerin clearance.
摘要翻译： 本文提供了用于治疗原型疾病和病症，细胞衰老，骨疾病和心血管疾病的组合疗法。 所提供的组合疗法针对突变型蛋白质A蛋白progerin的异常法呢基化，并且抑制法呢基生物合成，层析蛋白A异戊烯基化，并增加progerin清除率。
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5.发明申请公开(公告)号：US20190046508A1
公开(公告)日：2019-02-14
申请号：US16159716
申请日：2018-10-15
IPC分类号： A61K31/436 , A61K31/4545 , A61K45/06 , A61K31/22
摘要： Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin and increase progerin clearance.
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6.发明申请COMBINATION THERAPIES FOR TREATMENT OF LAMINOPATHIES, CELLULAR AGING, AND ATHEROSCLEROSIS 审中-公开治疗肌瘤，细胞衰老和甲状腺功能亢进的联合治疗公开(公告)号：US20160310473A1
公开(公告)日：2016-10-27
申请号：US15201525
申请日：2016-07-04
IPC分类号： A61K31/436 , A61K9/00 , A61K9/20 , A61K31/4545
CPC分类号： A61K31/436 , A61K9/0053 , A61K9/20 , A61K31/22 , A61K31/4545 , A61K31/55 , A61K31/663 , A61K31/675 , A61K45/06 , A61K2300/00
摘要： Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin and increase progerin clearance.
摘要翻译： 本文提供了用于治疗原型疾病和病症，细胞衰老，骨疾病和心血管疾病的组合疗法。 所提供的组合疗法针对突变体蛋白A蛋白质progerin的异常法呢基化，并增加progerin清除率。
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7.发明授权公开(公告)号：US10098871B2
公开(公告)日：2018-10-16
申请号：US15201525
申请日：2016-07-04
IPC分类号： A61K31/21 , A61K31/44 , A61K31/675 , A61K31/436 , A61K31/4545 , A61K9/00 , A61K9/20 , A61K45/06 , A61K31/22 , A61K31/55 , A61K31/663
摘要： Provided herein are combination therapies for the treatment of progeroid diseases and conditions, cellular aging, bone diseases, and cardiovascular diseases. The provided combination therapies target the aberrant farnesylation of the mutant lamin A protein progerin and increase progerin clearance.
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