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公开(公告)号：US20240075157A1
公开(公告)日：2024-03-07
申请号：US18156305
申请日：2023-01-18
发明人： Anthony Boitano , Michael Cooke , Charlotte Fenton McDonagh , Rahul Palchaudhuri , Bradley R. Pearse , Ganapathy N. Sarma
CPC分类号： A61K47/6849 , A61K47/6831 , C07K16/2806 , C07K16/2875 , C07K16/2878 , C07K16/289 , C07K16/2896
摘要： Disclosed are antibodies and antibody drug conjugates having an Fc region with substitutions resulting in essentially a silent Fc region. The antibodies and antibody drug conjugates described herein are useful for the depletion of cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, e.g., acute myeloid leukemia (AML) and autoimmune diseases, among others. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting, e.g., a population of CD45+ or CD117+ cancer cells or CD45+ autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.
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公开(公告)号：US11572411B2
公开(公告)日：2023-02-07
申请号：US16950522
申请日：2020-11-17
发明人： Bradley R. Pearse , Anthony Boitano , Rahul Palchaudhuri , Sean McDonough , Rajiv Panwar , Jonathan Philip Belk , Matthew Duncan Smith
IPC分类号： C07K16/28 , A61K35/545 , C07K7/64 , A61P37/06 , A61P35/00 , A61K47/68 , A61K38/00 , A61K35/12 , A61K39/00
摘要： The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ cells in a patient, such as a human. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD117+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.
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公开(公告)号：US20220273811A1
公开(公告)日：2022-09-01
申请号：US17457583
申请日：2021-12-03
摘要： Disclosed are methods and compositions relating to the treatment of autoimmune diseases using anti-CD45 antibody drug conjugates (ADCs).
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公开(公告)号：US20220267441A1
公开(公告)日：2022-08-25
申请号：US17452028
申请日：2021-10-22
发明人： Anthony Boitano , Michael Cooke , Charlotte Fenton McDonagh , Rahul Palchaudhuri , Rajiv Panwar , Bradley Pearse , Paul Fredrick Widboom , Patricia Ann Cruite
摘要： Disclosed are anti-CD45 antibodies, antigen binding fragments thereof, and antibody drug conjugates (ADCs) that specifically bind to human CD45. Such antibodies and ADCs are useful in therapeutic methods, including methods of depleting CD45+ cells from a patient. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD45+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy, and to improve the engraftment of hematopoietic stem cell transplants, by selectively depleting endogenous CD45+ cells prior to the transplant procedure.
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公开(公告)号：US20220226493A1
公开(公告)日：2022-07-21
申请号：US17507531
申请日：2021-10-21
发明人： Charlotte Fenton McDonagh , Anthony Boitano , Michael Cooke , Ganapathy N. Sarma , Rajiv Panwar
摘要： Antibody-drug conjugates (ADCs) comprising an anthracycline and an anti-CD117 antibody are provided, as well as compositions and methods of using the same. The compositions and methods provided herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure. Methods and compositions for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, are provided.
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公开(公告)号：US20220177577A1
公开(公告)日：2022-06-09
申请号：US17508759
申请日：2021-10-22
发明人： Charlotte Fenton McDonagh , Anthony Boitano , Michael Cooke , Ganapathy N. Sarma , Rajiv Panwar
摘要： Anti-CD117 antibody-drug conjugates (ADCs) comprising calicheamicin and are provided, as well as compositions and methods of using the same. The compositions and methods provided herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure. Methods and compositions for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, are provided.
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公开(公告)号：US20220175946A1
公开(公告)日：2022-06-09
申请号：US17507456
申请日：2021-10-21
摘要： The disclosure provides compositions and methods useful for the depletion of a specific population of endogenous hematopoietic stem cells and/or immune cells from a subject prior to transplantation with genetically modified stem cells to improve the engraftment of the transplanted stem cells and provide gene therapy. The disclosure provides compositions and methods for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ or CD45+ cells in a patient, such as a human.
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公开(公告)号：US20220062339A1
公开(公告)日：2022-03-03
申请号：US17368815
申请日：2021-07-06
摘要： The invention provides methods of depleting CD45+ cells in human patients undergoing chimeric antigen receptor (CAR) immunotherapy in order to promote acceptance of CAR expressing immune cells. Anti-CD45 antibody drug conjugates (ADCs) are administered as a conditioning regimen to a human patient receiving autologous or allogeneic CAR expressing immune cells such that the CAR expressing immune cells are accepted by the human patient. Compositions and methods of the invention can be used in combination with CAR therapy to treat a variety of pathologies, including autoimmune diseases and cancer.
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公开(公告)号：US20210371524A1
公开(公告)日：2021-12-02
申请号：US17244856
申请日：2021-04-29
发明人： Rahul Palchaudhuri , Bradley R. Pearse , Hillary Adams , Sean McDonough , Michael Cooke , Anthony Boitano
摘要： Disclosed are anti-CD45 antibodies and antibody drug conjugates (ADCs) useful in therapeutic methods, including targeting CD45 expressing hematopoietic stem cells (HSCs) or immune cells prior to transplantation.
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公开(公告)号：US10899843B2
公开(公告)日：2021-01-26
申请号：US16168823
申请日：2018-10-23
发明人： Bradley R. Pearse , Michael Cooke , Anthony Boitano , Rahul Palchaudhuri , Sean McDonough , Rajiv Panwar , Jacob Glanville
IPC分类号： C07K16/28 , A61P35/00 , A61K35/545 , C07K7/64 , A61P37/06 , A61K47/68 , A61K38/00 , A61K35/12 , A61K39/00
摘要： The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, e.g., acute myeloid leukemia (AML) and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ cells in a patient, such as a human. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD117+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.
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