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    Drug active in neuropathic pain
    7.
    发明授权
    Drug active in neuropathic pain 有权
    药物活性在神经性疼痛

    公开(公告)号：US08455519B2

    公开(公告)日：2013-06-04

    申请号：US12738499

    申请日：2008-11-06

    申请人： Maria Alessandra Alisi ,  Nicola Cazzolla ,  Guido Furlotti ,  Angelo Guglielmotti ,  Lorenzo Polenzani

    发明人： Maria Alessandra Alisi ,  Nicola Cazzolla ,  Guido Furlotti ,  Angelo Guglielmotti ,  Lorenzo Polenzani

    IPC分类号： C07D211/32 ,  A61K31/445

    CPC分类号： C07D401/12 ,  C07D401/14

    摘要： The present invention relates to a compound of formula (I): in which: R is a linear or branched alkyl group containing between 1 and 3 carbon atoms, Y is CH or N, and p is an integer between 0 and 3 and preferably 0 and 1, and salts thereof, either acid-addition salts with a pharmaceutically acceptable organic or mineral acid, or base-addition salts with a pharmaceutically acceptable organic or mineral base. The invention also relates to a process for preparing the compound of formula (I), and to a pharmaceutical composition comprising it. The invention also relates to the use of an indazole for preparing a pharmaceutical composition that is active in the treatment of neuropathic pain.

    摘要翻译： 本发明涉及式（I）化合物：其中：R为含有1至3个碳原子的直链或支链烷基，Y为CH或N，p为0至3之间的整数，优选为0 和其盐，与药学上可接受的有机或无机酸的酸加成盐，或与药学上可接受的有机或矿物碱的碱加成盐。 本发明还涉及制备式（I）化合物的方法以及包含其的药物组合物。 本发明还涉及吲唑用于制备治疗神经性疼痛的药物组合物的用途。

    DRUG ACTIVE IN NEUROPATHIC PAIN
    9.
    发明申请
    DRUG ACTIVE IN NEUROPATHIC PAIN 有权
    药物在神经性疼痛中的作用

    公开(公告)号：US20100215742A1

    公开(公告)日：2010-08-26

    申请号：US12738499

    申请日：2008-11-06

    申请人： Maria Alessandra Alisi ,  Nicola Cazzolla ,  Guido Furlotti ,  Angelo Guglielmotti ,  Lorenzo Polenzani

    发明人： Maria Alessandra Alisi ,  Nicola Cazzolla ,  Guido Furlotti ,  Angelo Guglielmotti ,  Lorenzo Polenzani

    IPC分类号： A61K31/454 ,  C07D401/12 ,  A61K9/28 ,  C07D401/14 ,  A61K31/4545 ,  A61P25/00

    CPC分类号： C07D401/12 ,  C07D401/14

    摘要： The present invention relates to a compound of formula (I): in which: R is a linear or branched alkyl group containing between 1 and 3 carbon atoms, Y is CH or N, and p is an integer between 0 and 3 and preferably 0 and 1, and salts thereof, either acid-addition salts with a pharmaceutically acceptable organic or mineral acid, or base-addition salts with a pharmaceutically acceptable organic or mineral base. The invention also relates to a process for preparing the compound of formula (I), and to a pharmaceutical composition comprising it. The invention also relates to the use of an indazole for preparing a pharmaceutical composition that is active in the treatment of neuropathic pain.

    摘要翻译： 本发明涉及式（I）化合物：其中：R为含有1至3个碳原子的直链或支链烷基，Y为CH或N，p为0至3之间的整数，优选为0 和其盐，与药学上可接受的有机或无机酸的酸加成盐，或与药学上可接受的有机或矿物碱的碱加成盐。 本发明还涉及制备式（I）化合物的方法以及包含其的药物组合物。 本发明还涉及吲唑用于制备治疗神经性疼痛的药物组合物的用途。