公开(公告)号：US06436658B1

公开(公告)日：2002-08-20

申请号：US09605685

申请日：2000-06-26

Applicant: Leo Seman

Inventor： Leo Seman

IPC: C12Q134

CPC classification number: G01N33/6842 ,  C12Q1/527 ,  G01N33/6815

Abstract: The invention relates to a method for determining homocysteine concentration in samples in which homocysteine is condensed using an enzyme cystathionine &bgr; sythase to form cystathionine. Pyruvate and/or ammonia are released from cystathionine by action of an enzyme, cystathionine &bgr; lyase, and homocysteine is regenerated. The release of pyruvate and/or ammonia can be correlated to the concentration of homocysteine present in the sample.

Abstract translation: 本发明涉及一种测定样品中同型半胱氨酸浓度的方法，其中同型半胱氨酸使用胱硫醚β酶进行浓缩以形成胱硫醚。 丙酮酸和/或氨通过酶的作用从胱硫醚释放，胱硫醚β裂解酶和同型半胱氨酸被再生。 丙酮酸和/或氨的释放可以与样品中存在的同型半胱氨酸的浓度相关。

公开(公告)号：US20140088027A1

公开(公告)日：2014-03-27

申请号：US13637413

申请日：2011-03-28

Applicant: Rolf Grempler ,  Thomas Klein ,  Michael Mark ,  Leo Seman ,  Leo Thomas

Inventor： Rolf Grempler ,  Thomas Klein ,  Michael Mark ,  Leo Seman ,  Leo Thomas

IPC: A61K31/7048 ,  A61K31/4439

CPC classification number: A61K31/7048 ,  A61K31/4439 ,  A61K31/70 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention relates to a pharmaceutical composition comprising an SGLT2 inhibitor and a PPARγ agonist which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.

Abstract translation: 本发明涉及包含SGLT2抑制剂和PPARγ激动剂的药物组合物，其适用于治疗或预防选自1型糖尿病，2型糖尿病，葡萄糖耐量异常和高血糖症的一种或多种病症。 此外，本发明涉及用于预防或治疗代谢紊乱及相关病症的方法。

公开(公告)号：US06174696B1

公开(公告)日：2001-01-16

申请号：US09440001

申请日：1999-11-12

Applicant: Leo Seman

Inventor： Leo Seman

IPC: C12Q134

CPC classification number: G01N33/6842 ,  C12Q1/527 ,  G01N33/6815

Abstract: The invention relates to a method for determining homocysteine concentration in samples in which homocysteine is condensed using an enzyme cystathionine &bgr; sythase to form cystathionine. Pyruvate and/or ammonia are released from cystathionine by action of an enzyme, cystathionine &bgr; lyase, and homocysteine is regenerated. The release of pyruvate and/or ammonia can be correlated to the concentration of homocysteine present in the sample.

Abstract translation: 本发明涉及一种测定样品中同型半胱氨酸浓度的方法，其中同型半胱氨酸使用胱硫醚β酶进行浓缩以形成胱硫醚。 丙酮酸和/或氨通过酶的作用从胱硫醚释放，胱硫醚β裂解酶和同型半胱氨酸被再生。 丙酮酸和/或氨的释放可以与样品中存在的同型半胱氨酸的浓度相关。