公开(公告)号：US5888995A

公开(公告)日：1999-03-30

申请号：US493733

申请日：1995-06-22

申请人： Bengt Ingemar Axelsson ,  Ralph Lennart Brattsand ,  Leif Arne Kallstrom ,  Bror Arne Thalen

发明人： Bengt Ingemar Axelsson ,  Ralph Lennart Brattsand ,  Leif Arne Kallstrom ,  Bror Arne Thalen

IPC分类号： C07J71/00 ,  A61K31/58

CPC分类号： C07J71/0031

摘要： The invention concerns compounds of formula I ##STR1## in which R.sub.1 is hydrogen or a straight or branched hydrocarbon chain; R.sub.2 is hydrogen or a straight or branched hydrocarbon chain; R.sub.3 is acyl; X.sub.1 is hydrogen, fluorine or chlorine; and X.sub.2 is hydrogen, fluorine or chlorine. Also disclosed are processes for preparation of the compounds, pharmaceutical compositions containing them and methods employing the compounds in the treatment of inflammatory and allergic conditions.

摘要翻译： 本发明涉及其中R 1为氢或直链或支链烃链的式Ⅰ化合物; R2是氢或直链或支链烃链; R3是酰基; X1是氢，氟或氯; X2是氢，氟或氯。 还公开了制备化合物的方法，含有它们的药物组合物和使用该化合物治疗炎性和过敏性疾病的方法。