公开(公告)号：US20090175919A1

公开(公告)日：2009-07-09

申请号：US11969591

申请日：2008-01-04

申请人： Brian H. Thomas ,  Donald L. Yakimicki ,  Steven Charlebois ,  Laura L. Borgstede ,  Niels Abt ,  James J. Mason ,  Oludele Popoola

发明人： Brian H. Thomas ,  Donald L. Yakimicki ,  Steven Charlebois ,  Laura L. Borgstede ,  Niels Abt ,  James J. Mason ,  Oludele Popoola

IPC分类号： A61L27/14 ,  C08F120/10 ,  C08F116/06

CPC分类号： A61L27/52 ,  A61F2/32 ,  A61F2/442 ,  A61F2002/30062 ,  A61F2002/30075 ,  A61F2002/30673 ,  A61F2002/444 ,  A61F2210/0004 ,  A61F2210/0061 ,  A61L27/26 ,  A61L2430/06 ,  C08L33/26

摘要： The present invention provides a hydrogel composition comprising at least one polymer with functional groups including alcohol groups, acid groups, and amide groups and where the ratio of the functional alcohol groups to functional acid groups in the hydrogel composition ranges from about 16:1 to about 3:2. The present invention also provides a method of repairing an articulating surface in a body using the inventive composition. The inventive hydrogel composition is created by blending two or more polymers to achieve the desired ratio of functional groups, reacting at least one polymer with a reagent that results in the formation of alcohol, acid, and/or amide functional groups of the desired ratio, and/or polymerizing at least one monomer to achieve the desired ratio of functional groups.

摘要翻译： 本发明提供一种水凝胶组合物，其包含至少一种具有包括醇基，酸基和酰胺基团的官能团的聚合物，并且其中水凝胶组合物中官能醇基团与官能酸基团的比例为约16:1至约 3：2。 本发明还提供了使用本发明的组合物修复身体中的关节表面的方法。 本发明的水凝胶组合物是通过混合两种或更多种聚合物来实现所需比例的官能团，使至少一种聚合物与导致形成所需比例的醇，酸和/或酰胺官能团的试剂反应产生的， 和/或聚合至少一种单体以达到所需的官能团比例。

公开(公告)号：US08034362B2

公开(公告)日：2011-10-11

申请号：US11969591

申请日：2008-01-04

申请人： Brian H. Thomas ,  Donald L. Yakimicki ,  Steven Charlebois ,  Laura L. Borgstede ,  Niels Abt ,  James J. Mason ,  Oludele Popoola

发明人： Brian H. Thomas ,  Donald L. Yakimicki ,  Steven Charlebois ,  Laura L. Borgstede ,  Niels Abt ,  James J. Mason ,  Oludele Popoola

IPC分类号： A61L27/14 ,  C08F120/10 ,  C08F116/06

CPC分类号： A61L27/52 ,  A61F2/32 ,  A61F2/442 ,  A61F2002/30062 ,  A61F2002/30075 ,  A61F2002/30673 ,  A61F2002/444 ,  A61F2210/0004 ,  A61F2210/0061 ,  A61L27/26 ,  A61L2430/06 ,  C08L33/26

摘要： The present invention provides a hydrogel composition comprising at least one polymer with functional groups including alcohol groups, acid groups, and amide groups and where the ratio of the functional alcohol groups to functional acid groups in the hydrogel composition ranges from about 16:1 to about 3:2. The present invention also provides a method of repairing an articulating surface in a body using the inventive composition. The inventive hydrogel composition is created by blending two or more polymers to achieve the desired ratio of functional groups, reacting at least one polymer with a reagent that results in the formation of alcohol, acid, and/or amide functional groups of the desired ratio, and/or polymerizing at least one monomer to achieve the desired ratio of functional groups.

摘要翻译： 本发明提供一种水凝胶组合物，其包含至少一种具有包括醇基，酸基和酰胺基团的官能团的聚合物，并且其中水凝胶组合物中官能醇基团与官能酸基团的比例为约16:1至约 3：2。 本发明还提供了使用本发明的组合物修复身体中的关节表面的方法。 本发明的水凝胶组合物是通过混合两种或更多种聚合物来实现所需比例的官能团，使至少一种聚合物与导致形成所需比例的醇，酸和/或酰胺官能团的试剂反应产生的， 和/或聚合至少一种单体以达到所需的官能团比例。