公开(公告)号：US20240226342A1

公开(公告)日：2024-07-11

申请号：US18529171

申请日：2023-12-05

Applicant: Vijay Sharma ,  Lakshminarayana Satham ,  Jothilingam Sivapackiam

Inventor： Vijay Sharma ,  Lakshminarayana Satham ,  Jothilingam Sivapackiam

IPC: A61K51/04

CPC classification number: A61K51/0459

Abstract: The present disclosure provides compositions and methods for reactive oxygen species imaging agents. Compositions include a reactive oxygen species (ROS) imaging agent according to any one of Formulas (I-VI)a and (I-VII)b. Methods of detecting ROS in a subject include administering to the subject an effective amount of a composition comprising a reactive oxygen species (ROS) imaging agent according to any one of Formulas (I-VI)a and (I-VII)b, and exposing the subject to an imaging modality such as PET or CT. Administering the composition comprising the ROS imaging agent results in penetration of the ROS imaging agent into a membrane, oxidation of the ROS imaging 10 agent by ROS, and trapping of the ROS imaging agent in a cell membrane and intracellular compartments.