公开(公告)号：US20070111998A1

公开(公告)日：2007-05-17

申请号：US11546299

申请日：2006-10-12

Applicant: Siripragada Rao ,  Akella Satya Srinivas ,  Shikha Rani ,  Gaddam Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Duddu Sharada ,  Rajagopalan Nirmala ,  Velaiah Sivasudar ,  Lakshmanan Manikandan ,  Ramachandran Balaji

Inventor： Siripragada Rao ,  Akella Satya Srinivas ,  Shikha Rani ,  Gaddam Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Duddu Sharada ,  Rajagopalan Nirmala ,  Velaiah Sivasudar ,  Lakshmanan Manikandan ,  Ramachandran Balaji

IPC: A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/427 ,  A61K31/416 ,  A61K31/403 ,  C07D417/02 ,  C07D403/02 ,  C07D413/02

CPC classification number: C07D209/88 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12

Abstract: The present invention relates to novel heterocyclic compounds of the general formula (I), as IL-6 inhibitors, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their metabolites and prodrugs thereof. The present invention more particularly provides novel heterocyclic compounds of the general formula (I). Also included is a method for treatment of cancer, cancer cachexia and inflammatory diseases including immunological diseases, particularly those mediated by cytokines such as IL-6, through pSTAT3 inhibition, in a mammal comprising administering an effective amount of a compound of formula (I) as described above.

Abstract translation: 本发明涉及通式（I）的新型杂环化合物，作为IL-6抑制剂，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其水合物，其溶剂合物，其药学上可接受的盐和组合物 ，它们的代谢物和前药。 本发明更具体地提供了通式（I）的新型杂环化合物。 还包括在哺乳动物中治疗癌症，癌症恶病质和炎性疾病的方法，包括免疫疾病，特别是通过pSTAT3抑制的细胞因子如IL-6介导的疾病，包括给予有效量的式（I）化合物， 如上所述。

公开(公告)号：US07786142B2

公开(公告)日：2010-08-31

申请号：US11546299

申请日：2006-10-12

Applicant: Siripragada Mahender Rao ,  Akella Satya Surya Visweswara Srinvas ,  Shikha Rani ,  Gaddam Om Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Duddu Savaraiah Sharada ,  Rajagopalan Nirmala ,  Velaiah Sivasudar ,  Lakshmanan Manikandan ,  Ramachandran Balaji

Inventor： Siripragada Mahender Rao ,  Akella Satya Surya Visweswara Srinvas ,  Shikha Rani ,  Gaddam Om Reddy ,  Sriram Rajagopal ,  Uma Ramachandran ,  Duddu Savaraiah Sharada ,  Rajagopalan Nirmala ,  Velaiah Sivasudar ,  Lakshmanan Manikandan ,  Ramachandran Balaji

IPC: A61K31/4468 ,  A61K31/403 ,  C07D405/14 ,  C07D209/88

CPC classification number: C07D209/88 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12

Abstract: The present invention relates to novel heterocyclic compounds of the general formula (I), as IL-6 inhibitors, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and compositions, their metabolites and prodrugs thereof. The present invention more particularly provides novel heterocyclic compounds of the general formula (I). Also included is a method for treatment of cancer, cancer cachexia and inflammatory diseases including immunological diseases, particularly those mediated by cytokines such as IL-6, through pSTAT3 inhibition, in a mammal comprising administering an effective amount of a compound of formula (I) as described above

Abstract translation: 本发明涉及通式（I）的新型杂环化合物，作为IL-6抑制剂，其衍生物，其类似物，其互变异构形式，其立体异构体，其多晶型物，其水合物，其溶剂合物，其药学上可接受的盐和组合物 ，它们的代谢物和前药。 本发明更具体地提供了通式（I）的新型杂环化合物。 还包括在哺乳动物中治疗癌症，癌症恶病质和炎性疾病的方法，包括免疫疾病，特别是通过pSTAT3抑制的细胞因子如IL-6介导的疾病，包括给予有效量的式（I）化合物， 如上所述

公开(公告)号：US20070088043A1

公开(公告)日：2007-04-19

申请号：US11581570

申请日：2006-10-17

Applicant: Akella Satya Srinivas ,  Kilambi Narasimhan ,  Lakshmanan Manikandan ,  Sriram Rajagopal ,  Thangapazham Selvakumar ,  Gaddam Reddy

Inventor： Akella Satya Srinivas ,  Kilambi Narasimhan ,  Lakshmanan Manikandan ,  Sriram Rajagopal ,  Thangapazham Selvakumar ,  Gaddam Reddy

IPC: A61K31/496 ,  C07D417/02

CPC classification number: C07D277/46 ,  C07D277/82 ,  C07D295/185

Abstract: The present invention relates to novel compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions. The present invention more particularly provides novel HDAC inhibitors of the general formula (1). Also included is a method for treatment of cancer, psoriasis, proliferative conditions and conditions mediated by HDAC, in a mammal comprising administering an effective amount of a compound of formula (I) as described above.

Abstract translation: 本发明涉及通式（I）的新化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和组合物。 本发明更具体地提供了通式（1）的新型HDAC抑制剂。 还包括在哺乳动物中治疗癌症，牛皮癣，增殖性病症和由HDAC介导的病症的方法，包括给予有效量的如上所述的式（I）化合物。