公开(公告)号：US10519182B2

公开(公告)日：2019-12-31

申请号：US16097120

申请日：2018-01-31

申请人： Masamitsu Moriwaki ,  Kentaro Kumoi ,  Makoto Ozeki

发明人： Masamitsu Moriwaki ,  Kentaro Kumoi ,  Makoto Ozeki

IPC分类号： C07H17/07 ,  A23L3/3499 ,  A61K47/40 ,  A61K8/60 ,  A61K8/73 ,  A61K31/7048 ,  A23F3/16 ,  A23L2/02 ,  A23L2/44 ,  A23L21/10 ,  A23F5/24

摘要： A method for producing a flavonoid inclusion compound, including a cleaving step including treating a sparingly soluble flavonoid having a rhamnoside structure with an enzyme having a rhamnosidase activity in the presence of a cyclodextrin to cleave a rhamnose. According to the production method of the present invention, a flavonoid inclusion compound and a composition of flavonoid glycosides having excellent solubility in water can be efficiently produced, so that the compound and composition can be suitably utilized in the fields of medicaments, foodstuff, health foods, foods for specified health use, cosmetics, and the like.

公开(公告)号：US11446319B2

公开(公告)日：2022-09-20

申请号：US17056552

申请日：2018-10-03

申请人： Masamitsu Moriwaki ,  Kentaro Kumoi ,  Ryo Nakagawa ,  Miki Sagisaka ,  Makoto Ozeki

发明人： Masamitsu Moriwaki ,  Kentaro Kumoi ,  Ryo Nakagawa ,  Miki Sagisaka ,  Makoto Ozeki

IPC分类号： A61K31/7048 ,  A61K47/69 ,  A61K8/60 ,  A61K8/73 ,  A23L29/30 ,  A23L33/105 ,  A23L27/00 ,  A23L5/41 ,  A23L2/60

摘要： A composition containing one or more materials selected from the group consisting of fatty acids, proteins, peptides, amino acids, vitamins, minerals, alcohols, sweeteners, acidulants, antioxidants, thickening stabilizer, and surfactants, and a flavonoid-cyclodextrin inclusion compound, wherein the inclusion compound contains an inclusion compound obtained by treating a flavonoid having a rhamnoside structure with an enzyme having rhamnosidase activity in the presence of a cyclodextrin. According to the present invention, the bitterness and the changes in color tones originated from flavonoids can be inhibited, and foodstuff or the like having an unpleasant taste can be improved, so that the present invention can be suitably utilized in fields such as medicaments, foodstuff, health foods, foods for specified health use, and cosmetics.

公开(公告)号：US20190248825A1

公开(公告)日：2019-08-15

申请号：US16097120

申请日：2018-01-31

申请人： Masamitsu Moriwaki ,  Kentaro Kumoi ,  Makoto Ozeki

发明人： Masamitsu Moriwaki ,  Kentaro Kumoi ,  Makoto Ozeki

IPC分类号： C07H17/07 ,  A23L3/3499 ,  A61K47/40 ,  A61K8/60 ,  A61K8/73 ,  A61K31/7048

摘要： A method for producing a flavonoid inclusion compound, including a cleaving step including treating a sparingly soluble flavonoid having a rhamnoside structure with an enzyme having a rhamnosidase activity in the presence of a cyclodextrin to cleave a rhamnose. According to the production method of the present invention, a flavonoid inclusion compound and a composition of flavonoid glycosides having excellent solubility in water can be efficiently produced, so that the compound and composition can be suitably utilized in the fields of medicaments, foodstuff, health foods, foods for specified health use, cosmetics, and the like.

公开(公告)号：US20210205344A1

公开(公告)日：2021-07-08

申请号：US17056552

申请日：2018-10-03

申请人： Masamitsu MORIWAKI ,  Kentaro KUMOI ,  Ryo NAKAGAWA ,  Miki SAGISAKA ,  Makoto OZEKI

发明人： Masamitsu MORIWAKI ,  Kentaro KUMOI ,  Ryo NAKAGAWA ,  Miki SAGISAKA ,  Makoto OZEKI

IPC分类号： A61K31/7048 ,  A61K47/69 ,  A61K8/60 ,  A61K8/73 ,  A23L29/30 ,  A23L33/105 ,  A23L27/00 ,  A23L5/41 ,  A23L2/60

摘要： A composition containing one or more materials selected from the group consisting of fatty acids, proteins, peptides, amino acids, vitamins, minerals, alcohols, sweeteners, acidulants, antioxidants, thickening stabilizer, and surfactants, and a flavonoid-cyclodextrin inclusion compound, wherein the inclusion compound contains an inclusion compound obtained by treating a flavonoid having a rhamnoside structure with an enzyme having rhamnosidase activity in the presence of a cyclodextrin. According to the present invention, the bitterness and the changes in color tones originated from flavonoids can be inhibited, and foodstuff or the like having an unpleasant taste can be improved, so that the present invention can be suitably utilized in fields such as medicaments, foodstuff, health foods, foods for specified health use, and cosmetics.

公开(公告)号：US10676496B2

公开(公告)日：2020-06-09

申请号：US16669753

申请日：2019-10-31

申请人： Masamitsu Moriwaki ,  Kentaro Kumoi ,  Makoto Ozeki

发明人： Masamitsu Moriwaki ,  Kentaro Kumoi ,  Makoto Ozeki

IPC分类号： C07H17/07 ,  A61K47/40 ,  A61K8/73 ,  A61K9/00 ,  A23L33/105 ,  A61Q19/00 ,  A23L33/00 ,  A61K8/49 ,  C07H1/00 ,  C12P19/14 ,  C12P19/02 ,  A61K9/20 ,  A61K9/19 ,  A61K9/08 ,  C12P19/18 ,  A23L3/3499 ,  A61K8/60 ,  A61K31/7048 ,  A23L21/10 ,  A23F3/16 ,  A23F5/24 ,  A23L2/02 ,  A23L2/44

摘要： A method for producing a flavonoid inclusion compound, including a cleaving step including treating a sparingly soluble flavonoid having a rhamnoside structure with an enzyme having a rhamnosidase activity in the presence of a cyclodextrin to cleave a rhamnose. According to the production method of the present invention, a flavonoid inclusion compound and a composition of flavonoid glycosides having excellent solubility in water can be efficiently produced, so that the compound and composition can be suitably utilized in the fields of medicaments, foodstuff, health foods, foods for specified health use, cosmetics, and the like.

公开(公告)号：US20200062796A1

公开(公告)日：2020-02-27

申请号：US16669753

申请日：2019-10-31

申请人： Masamitsu MORIWAKI ,  Kentaro KUMOI ,  Makoto OZEKI

发明人： Masamitsu MORIWAKI ,  Kentaro KUMOI ,  Makoto OZEKI

IPC分类号： C07H17/07 ,  A61K9/00 ,  A23L33/105 ,  A61Q19/00 ,  A23L33/00 ,  A61K8/49 ,  C07H1/00 ,  C12P19/14 ,  C12P19/02 ,  A61K9/20 ,  A61K9/19 ,  A61K9/08 ,  C12P19/18 ,  A61K47/40 ,  A61K8/73 ,  A23L3/3499 ,  A61K8/60 ,  A61K31/7048

摘要： A method for producing a flavonoid inclusion compound, including a cleaving step including treating a sparingly soluble flavonoid having a rhamnoside structure with an enzyme having a rhamnosidase activity in the presence of a cyclodextrin to cleave a rhamnose. According to the production method of the present invention, a flavonoid inclusion compound and a composition of flavonoid glycosides having excellent solubility in water can be efficiently produced, so that the compound and composition can be suitably utilized in the fields of medicaments, foodstuff, health foods, foods for specified health use, cosmetics, and the like.