公开(公告)号：US5955481A

公开(公告)日：1999-09-21

申请号：US18843

申请日：1998-02-04

Applicant: Yoshio Ohara ,  Mikio Suzuki ,  Nobuhide Miyachi ,  Katsuhiro Kato ,  Keisuke Ohdoi ,  Tetsuya Kobayashi ,  Ken-ichi Shikada ,  Takeshi Naito ,  Takashi Yotsumoto

Inventor： Yoshio Ohara ,  Mikio Suzuki ,  Nobuhide Miyachi ,  Katsuhiro Kato ,  Keisuke Ohdoi ,  Tetsuya Kobayashi ,  Ken-ichi Shikada ,  Takeshi Naito ,  Takashi Yotsumoto

IPC: C07D417/06 ,  C07D417/14 ,  A61K31/42 ,  A61K31/425

CPC classification number: C07D417/06 ,  C07D417/14

Abstract: The present invention provides novel pyridine type thiazolidines and their salts, expressed by the following formula (I): ##STR1##

Abstract translation: 本发明提供新的吡啶型噻唑烷及其盐，由下式（I）表示：

公开(公告)号：US5272271A

公开(公告)日：1993-12-21

申请号：US726897

申请日：1991-07-08

Applicant: Kiyotomo Seto ,  Hiroo Matsumoto ,  Yoshimasa Kamikawaji ,  Kazuhiko Ohrai ,  Keisuke Ohdoi ,  Ryozo Sakoda ,  Yukinori Masuda

Inventor： Kiyotomo Seto ,  Hiroo Matsumoto ,  Yoshimasa Kamikawaji ,  Kazuhiko Ohrai ,  Keisuke Ohdoi ,  Ryozo Sakoda ,  Yukinori Masuda

IPC: A61K31/41 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  C07D498/04 ,  C07F7/18 ,  C07D403/04 ,  C07D271/12

CPC classification number: C07D498/04 ,  C07F7/1856

Abstract: A compound of the formula (I): ##STR1## wherein X.sup.1 and X.sup.2 do not exist or represent oxygen atom; A represents OH or acyloxy group having 1 to 4 carbon atoms; B represents hydrogen atom; A and B together represent a bond; R.sup.1 and R.sup.2 represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together represent 1,2-ethylene, 1,3-propylene, 1,4-butylene or 1,5-pentylene, and these alkylene groups may be substituted by alkyl group having 1 to 4 carbon atoms; R.sup.3 represents amido group of the formula: ##STR2## wherein n, R.sup.4, R.sup.5, R.sup.6, R.sup.7. R.sup.8. R.sup.9, R.sup.10 and R.sup.11 represent specific groups, and the pharmacological acceptable salts of the compounds which can form salts have strong activity for lowering blood pressure, and process therefor and pharmaceutical use of the compounds.