公开(公告)号：US20100111860A1

公开(公告)日：2010-05-06

申请号：US12263573

申请日：2008-11-03

Applicant: Tsai-Yueh LUO ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

Inventor： Tsai-Yueh LUO ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

IPC: A61K51/06 ,  C08B37/08 ,  A61P35/00

CPC classification number: A61K51/065 ,  C08B37/003 ,  C08L5/08

Abstract: A radioactive material containing chitosan for inhibiting cancer and a preparation method thereof are revealed. The adioactive material containing chitosan is formed by using SOCTA chelating agent to connect chitosan and radionuclides such as 188Re, and Tc-99m etc. The preparation method of the radioactive material containing chitosan includes the steps of: prepare SOCTA-Chitosan compound; and prepare M(radionuclide)-SOCTA-Chitosan compound. By biocompatibility and clotting in alkaline environment of human blood of chitosan, the radioactive material containing chitosan is injected into cancer and staying there for a long time so as to achieve effectively treatment.

Abstract translation: 揭示含有用于抑制癌症的壳聚糖的放射性物质及其制备方法。 通过使用SOCTA螯合剂将壳聚糖与188Re，Tc-99m等放射性核素连接起来形成含有壳聚糖的活性物质。含有脱乙酰壳多糖的放射性物质的制备方法包括以下步骤：制备SOCTA-壳聚糖化合物; 并制备M（放射性核素）-SOCTA-壳聚糖化合物。 通过壳聚糖人血液碱性环境的生物相容性和凝血作用，将含有脱乙酰壳多糖的放射性物质注入癌症并长时间停留，以有效治疗。

公开(公告)号：US08367811B2

公开(公告)日：2013-02-05

申请号：US12263573

申请日：2008-11-03

Applicant: Tsai-Yueh Luo ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

Inventor： Tsai-Yueh Luo ,  I-Chung Tang ,  Jian-Wen Chen ,  Kwei-Luen Hsu ,  Yu-Lung Wu ,  Te-Sheng Liang ,  Chang-Mau Sheng ,  Jin-Jenn Lin ,  Ching-Jun Liou ,  Jyh-Daw Sheu

IPC: C07F13/00

CPC classification number: A61K51/065 ,  C08B37/003 ,  C08L5/08

Abstract: A radioactive material containing chitosan for inhibiting cancer and a preparation method thereof are revealed. The adioactive material containing chitosan is formed by using SOCTA chelating agent to connect chitosan and radionuclides such as 188Re, and Tc-99m etc. The preparation method of the radioactive material containing chitosan includes the steps of: prepare SOCTA-Chitosan compound; and prepare M(radionuclide)-SOCTA-Chitosan compound. By biocompatibility and clotting in alkaline environment of human blood of chitosan, the radioactive material containing chitosan is injected into cancer and staying there for a long time so as to achieve effectively treatment.

Abstract translation: 揭示含有用于抑制癌症的壳聚糖的放射性物质及其制备方法。 通过使用SOCTA螯合剂将壳聚糖与188Re，Tc-99m等放射性核素连接起来形成含有壳聚糖的活性物质。含有脱乙酰壳多糖的放射性物质的制备方法包括以下步骤：制备SOCTA-壳聚糖化合物; 并制备M（放射性核素）-SOCTA-壳聚糖化合物。 通过壳聚糖人血液碱性环境的生物相容性和凝血作用，将含有脱乙酰壳多糖的放射性物质注入癌症并长时间停留，以有效治疗。