公开(公告)号：US20070143031A1

公开(公告)日：2007-06-21

申请号：US11702987

申请日：2007-02-06

Applicant: Yang-Suk Kim ,  Jung-Uk Hur ,  Sung-Geun Lee

Inventor： Yang-Suk Kim ,  Jung-Uk Hur ,  Sung-Geun Lee

IPC: G06F19/00

CPC classification number: G16B50/00 ,  G16B25/00 ,  G16B40/00

Abstract: Disclosed is a system for analyzing a bio chip using Gene Ontology (hereinafter referred to “GO”) and a method thereof. According to a preferred embodiment of the present invention, it is provided a system for analyzing a bio chip comprising: a GO (gene ontology) term assigning part for receiving a statistical clustering data obtained from empirical results of the bio chip, and assigning relevant GO terms to every gene contained in each cluster; a GO code converting part for converting the GO terms assigned by the GO term assigning part to the genes into GO codes, the GO code comprising a group of predetermined numbers; and a biological meaning extracting part for calculating pseudo distances between one of GO terms on GO tree structure contained in a predetermined group and the GO terms corresponding to the genes contained in the cluster, and calculating at least one of average pseudo distance or maximum pseudo distance of the calculated pseudo distances, and calculating at least one of average pseudo distances or maximum pseudo distances for all GO terms included on GO tree structure in the predetermined group and the GO terms corresponding to the genes contained in the cluster, and determining an optimum GO term matching with the cluster.

Abstract translation: 公开了使用基因本体（以下称为“GO”）分析生物芯片的方法及其方法。 根据本发明的优选实施例，提供了一种用于分析生物芯片的系统，包括：GO（基因本体）术语分配部分，用于接收从生物芯片的经验结果获得的统计聚类数据，并分配相关的GO 对每个簇中每个基因的术语; GO代码转换部分，用于将由GO条目分配部分分配给GO基因的GO条目转换成GO代码，GO代码包括一组预定数量; 以及用于计算包含在预定组中的GO树结构上的GO项之一和与所述簇中包含的基因相对应的GO项之间的伪距离的生物意义提取部分，并且计算平均伪距离或最大伪距离 的计算的伪距离，并且计算包含在预定组中的GO树结构上的所有GO项的平均伪距离或最大伪距离中的至少一个，以及对应于簇中包含的基因的GO项，并且确定最佳GO 与群集的长期匹配。

公开(公告)号：US20060234244A1

公开(公告)日：2006-10-19

申请号：US10579504

申请日：2004-08-23

Applicant: Yang-Suk Kim ,  Jung-Uk Hur ,  Sung-Geun Lee

Inventor： Yang-Suk Kim ,  Jung-Uk Hur ,  Sung-Geun Lee

IPC: C12Q1/68 ,  G06F19/00

CPC classification number: G16B50/00 ,  G16B25/00 ,  G16B40/00

Abstract: Disclosed is a system for analyzing a bio chip using Gene Ontology(hereinafter referred to “GO”) and a method thereof. According to a preferred embodiment of the present invention, it is provided a system for analyzing a bio chip comprising: a GO(gene ontology) term assigning part for receiving a statistical clustering data obtained from empirical results of the bio chip, and assigning relevant GO terms to every gene contained in each cluster; a GO code converting part for converting the GO terms assigned by the GO term assigning part to the genes into GO codes, the GO code comprising a group of predetermined numbers; and a biological meaning extracting part for calculating pseudo distances between one of GO terms on GO tree structure contained in a predetermined group and the GO terms corresponding to the genes contained in the cluster, and calculating at least one of average pseudo distance or maximum pseudo distance of the calculated pseudo distances, and calculating at least one of average pseudo distances or maximum pseudo distances for all GO terms included on GO tree structure in the predetermined group and the GO terms corresponding to the genes contained in the cluster, and determining an optimum GO term matching with the cluster.

Abstract translation: 公开了使用基因本体（以下称为“GO”）分析生物芯片的方法及其方法。 根据本发明的优选实施例，提供了一种用于分析生物芯片的系统，包括：GO（基因本体）术语分配部分，用于接收从生物芯片的经验结果获得的统计聚类数据，并分配相关的GO 对每个簇中每个基因的术语; GO代码转换部分，用于将由GO条目分配部分分配给GO基因的GO条目转换成GO代码，GO代码包括一组预定数量; 以及用于计算包含在预定组中的GO树结构上的GO项之一和与所述簇中包含的基因相对应的GO项之间的伪距离的生物意义提取部分，并且计算平均伪距离或最大伪距离 的计算的伪距离，并且计算包含在预定组中的GO树结构上的所有GO项的平均伪距离或最大伪距离中的至少一个，以及对应于簇中包含的基因的GO项，并且确定最佳GO 与群集的长期匹配。