公开(公告)号：US09980731B2

公开(公告)日：2018-05-29

申请号：US13436638

申请日：2012-03-30

申请人： Juan A. Lorenzo

发明人： Juan A. Lorenzo

IPC分类号： A61M29/00 ,  A61B17/12 ,  A61B17/00

CPC分类号： A61B17/12031 ,  A61B17/12113 ,  A61B17/12154 ,  A61B2017/00004 ,  A61B2017/00871 ,  A61B2017/12068 ,  A61B2017/12072 ,  A61B2017/12077

摘要： Provided herein are a system and method for detaching a therapeutic device, e.g. an embolic coil, from a delivery tube at a target site in a patient's body. The system includes a bead disposed against a distal end of the therapeutic device that retains the therapeutic device to the delivery tube in a first compressed configuration through a coupling union comprising a series of connectors. The series of connectors may include a stretch resistant member through which the bead is attached to an anchor inside the therapeutic device. The anchor, in turn, may be disposed against a thermally responsive element comprised of a polymeric material configured to melt or otherwise change configuration to release the anchor, and with it, to also release the therapeutic device. Energy may be supplied to the thermally responsive element through electrical conductors and a resistive heating element disposed within the delivery tube.

公开(公告)号：US09808255B2

公开(公告)日：2017-11-07

申请号：US13436376

申请日：2012-03-30

申请人： Juan A. Lorenzo ,  Kirk Johnson

发明人： Juan A. Lorenzo ,  Kirk Johnson

IPC分类号： A61B17/12 ,  A61B17/00

CPC分类号： A61B17/1214 ,  A61B2017/00867 ,  A61B2017/00871 ,  A61B2017/00951 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61B2017/12068 ,  A61B2017/12077

摘要： An embolic coil detachment system includes an elongated, flexible shape memory polymer tube having an inner wall surface defining an interior lumen. A distal portion of the shape memory polymer tube has an enlarged and reduced diameter configurations. An embolic coil is releasably mounted to the shape memory polymer tube by a headpiece releasably attached within a distal portion of the shape memory polymer tube. A resistive heating element disposed longitudinally along and in immediate contact with the inner wall surface of the distal tubular wall of the shape memory polymer tube provides direct, even heating to release the headpiece and embolic coil attached thereto when the resistive heating element is energized.

公开(公告)号：US08932318B2

公开(公告)日：2015-01-13

申请号：US13436236

申请日：2012-03-30

申请人： Juan A. Lorenzo

发明人： Juan A. Lorenzo

IPC分类号： A61M29/00

CPC分类号： A61B17/12154 ,  A61B2017/00004 ,  A61B2017/12068 ,  A61B2017/12072 ,  A61B2017/12077

摘要： Provided herein are a system and method for detaching a therapeutic device, e.g. an embolic coil, from a delivery tube at a target site in a patient's body. The system includes a bead disposed against a distal end of the therapeutic device that retains the therapeutic device to the delivery tube in a first compressed configuration through a series of connectors. The series of connectors include a stretch resistant member through which the bead is attached to an anchor inside the therapeutic device. The anchor, in turn, is disposed against a thermally responsive element comprised of a polymeric material configured to melt or otherwise change configuration to release the anchor, and with it, to also release the bead and therapeutic device. Energy may be supplied to the thermally responsive element through electrical conductors and a resistive heating element disposed within the delivery tube.

摘要翻译： 本文提供了一种用于分离治疗装置的系统和方法，例如， 来自患者体内目标部位的输送管的栓塞线圈。 该系统包括靠近治疗装置的远端设置的珠，其通过一系列连接器以第一压缩构型将治疗装置保持在输送管上。 该连接器系列包括一个抗拉构件，通过该构件，胎圈与治疗装置内的锚固件连接。 锚固件反过来被设置在由热聚合物材料构成的热响应元件上，所述热响应元件被构造成熔化或以其他方式改变构型以释放锚固件，并且与其一起释放珠粒和治疗装置。 可以通过电导体和布置在输送管内的电阻加热元件将能量提供给热响应元件。

公开(公告)号：US20140277078A1

公开(公告)日：2014-09-18

申请号：US13802101

申请日：2013-03-13

申请人： Robert R. Slazas ,  Juan A. Lorenzo

发明人： Robert R. Slazas ,  Juan A. Lorenzo

IPC分类号： A61B17/12

CPC分类号： A61B17/1214 ,  A61B17/12113 ,  A61B17/12154 ,  A61B2017/00309 ,  A61B2017/12054 ,  A61B2090/037

摘要： A delivery system for an embolic coil including a delivery tube having a lumen. A proximal coil junction is disposed between the delivery tube and the embolic coil. Insertable through the lumen and extending proximally beyond the proximal end of the delivery tube is a detachable wire with a terminating feature disposed on its distal end. At least one stretch resistant member is disposed within a lumen formed by the embolic coil. A distal end of each of the at least one stretch resistant members is secured to a distal end of the embolic coil, while each of the at least one stretch resistant members is also secured proximate the proximal end of the embolic coil. The distal end of the delivery tube is retained by the wire physically against without being attached in any way to the proximal junction.

摘要翻译： 一种用于栓塞线圈的输送系统，包括具有内腔的输送管。 近端线圈结设置在输送管和栓塞线圈之间。 可插入内腔并向近端延伸超过输送管的近端，是具有设置在其远端上的端接特征的可拆卸线。 至少一个抗拉构件设置在由栓塞线圈形成的内腔内。 至少一个抗拉构件中的每一个的远端固定到栓塞线圈的远端，而至少一个抗拉构件中的每一个也固定在栓塞线圈的近端附近。 输送管的远端由金属丝保持物理地抵靠而不以任何方式附接到近端连接处。

公开(公告)号：US20130261656A1

公开(公告)日：2013-10-03

申请号：US13436236

申请日：2012-03-30

申请人： Juan A. Lorenzo

发明人： Juan A. Lorenzo

IPC分类号： A61F2/01

CPC分类号： A61B17/12154 ,  A61B2017/00004 ,  A61B2017/12068 ,  A61B2017/12072 ,  A61B2017/12077

摘要： Provided herein are a system and method for detaching a therapeutic device, e.g. an embolic coil, from a delivery tube at a target site in a patient's body. The system includes a bead disposed against a distal end of the therapeutic device that retains the therapeutic device to the delivery tube in a first compressed configuration through a series of connectors. The series of connectors include a stretch resistant member through which the bead is attached to an anchor inside the therapeutic device. The anchor, in turn, is disposed against a thermally responsive element comprised of a polymeric material configured to melt or otherwise change configuration to release the anchor, and with it, to also release the bead and therapeutic device. Energy may be supplied to the thermally responsive element through electrical conductors and a resistive heating element disposed within the delivery tube.

摘要翻译： 本文提供了一种用于分离治疗装置的系统和方法，例如， 来自患者体内目标部位的输送管的栓塞线圈。 该系统包括靠近治疗装置的远端设置的珠，其通过一系列连接器以第一压缩构型将治疗装置保持在输送管上。 该连接器系列包括一个抗拉构件，通过该构件，胎圈与治疗装置内的锚固件连接。 锚固件反过来被设置在由热聚合物材料构成的热响应元件上，所述热响应元件被构造成熔化或以其他方式改变构型以释放锚固件，并且与其一起释放珠粒和治疗装置。 可以通过电导体和布置在输送管内的电阻加热元件将能量提供给热响应元件。

公开(公告)号：US20090270877A1

公开(公告)日：2009-10-29

申请号：US12085885

申请日：2006-12-12

申请人： Kirk L. Johnson ,  Juan A. Lorenzo ,  Robert Lulo

发明人： Kirk L. Johnson ,  Juan A. Lorenzo ,  Robert Lulo

IPC分类号： A61B19/00

CPC分类号： A61B17/12022 ,  A61B17/1214 ,  A61B2017/0046 ,  A61B2017/12054 ,  A61F2/95 ,  A61F2002/9505 ,  A61F2002/9511

摘要： A detachment actuator for use with an implantable medical device deployment system that guide and deploys the medical device at a target location within a body vessel. The detachment actuator includes a first portion that is connected the implantable medical device and a second portion that is attached to a control member the controls the release of the medical device, The second portion of the detachment actuator detaches and moves away from the first portion of the detachment actuator to move the control member and release the medical device.

摘要翻译： 一种与可植入医疗装置展开系统一起使用的分离致动器，其在医疗器皿内的目标位置处引导和部署医疗装置。 分离致动器包括连接可植入医疗装置的第一部分和附接到控制部件的第二部分，其控制医疗装置的释放。分离致动器的第二部分分离并远离第一部分 所述分离致动器移动所述控制构件并释放所述医疗装置。

公开(公告)号：US07377932B2

公开(公告)日：2008-05-27

申请号：US11143051

申请日：2005-06-02

申请人： Vladimir Mitelberg ,  Donald K. Jones ,  Juan A. Lorenzo

发明人： Vladimir Mitelberg ,  Donald K. Jones ,  Juan A. Lorenzo

IPC分类号： A61M29/00

CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/1214 ,  A61B2017/00477 ,  A61B2017/12054

摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member having a lumen therethrough and being slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member which is attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. When the embolic device is advanced to the predetermined site within the vessel, the detachment member is withdrawn from the aperture to thereby release the embolic device at the treatment site.

摘要翻译： 一种用于将栓塞装置放置在身体的容器内的预定位置处的医疗装置，包括输送导管和具有通过其的腔的柔性推动器构件，并且可滑动地设置在导管的腔内。 栓塞装置通过机械互锁机构保持在输送导管内，该联动机构包括接合构件，该接合构件附接到推动器构件的远端并延伸穿过栓塞装置的近端处的保持环。 分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。 当栓塞装置前进到血管内的预定位置时，分离构件从孔中取出，从而在治疗部位释放栓塞装置。

公开(公告)号：US09629739B2

公开(公告)日：2017-04-25

申请号：US13799437

申请日：2013-03-13

申请人： Robert R. Slazas ,  Juan A. Lorenzo

发明人： Robert R. Slazas ,  Juan A. Lorenzo

IPC分类号： A61F2/966

CPC分类号： A61F2/966 ,  A61F2002/9665 ,  A61F2230/0093

摘要： A delivery system including a distal capture device that has a sleeve with a passageway defined axially therethrough and one or more elastically deformable sections. Each of the one or more elastically deformable sections has a free terminating end and an opposite end mounted to the distal end of the sleeve. The elastically deformable sections transition between: (i) a fully expanded state in which the elastically deformable section is distally biased in a direction away from the sleeve; and (ii) a retracted state in which the free terminating end of each of the elastically deformable sections is proximally deflected backwards over itself in a direction toward the proximal end of the sleeve.

公开(公告)号：US08920459B2

公开(公告)日：2014-12-30

申请号：US13436430

申请日：2012-03-30

申请人： Juan A. Lorenzo

发明人： Juan A. Lorenzo

IPC分类号： A61M29/00

CPC分类号： A61B17/1214 ,  A61B2017/12077 ,  A61B2090/037

摘要： An embolic coil detachment system includes an elongated, flexible polymer tube having a tubular wall with an inner surface defining an interior lumen. A distal portion of the tubular wall has a score line, and a resistive heating element is located near the score line and in immediate contact with a surface of a distal portion of the tubular wall, to provide direct heating of the distal portion of the flexible polymer tube adjacent to the score line. A therapeutic embolic coil includes a headpiece that is releasably attached within the distal portion of the flexible polymer tube, and that is releasable by heating of the distal portion of the tubular shaft to cause the distal portion of the tubular wall to split along the score line.

摘要翻译： 栓塞线圈分离系统包括细长的柔性聚合物管，其具有带有限定内腔的内表面的管状壁。 管状壁的远侧部分具有刻痕线，并且电阻加热元件位于刻痕线附近并与管状壁的远端部分的表面立即接触，以提供柔性的远端部分的直接加热 聚合物管毗邻刻痕线。 治疗性栓塞线圈包括可释放地附接在柔性聚合物管的远侧部分内的头盔，并且其可通过加热管状轴的远端部分而释放，以使管状壁的远端部分沿着刻痕线分开 。

公开(公告)号：US20130261659A1

公开(公告)日：2013-10-03

申请号：US13436638

申请日：2012-03-30

申请人： Juan A. Lorenzo

发明人： Juan A. Lorenzo

IPC分类号： A61F2/01

CPC分类号： A61B17/12031 ,  A61B17/12113 ,  A61B17/12154 ,  A61B2017/00004 ,  A61B2017/00871 ,  A61B2017/12068 ,  A61B2017/12072 ,  A61B2017/12077

摘要： Provided herein are a system and method for detaching a therapeutic device, e.g. an embolic coil, from a delivery tube at a target site in a patient's body. The system includes a bead disposed against a distal end of the therapeutic device that retains the therapeutic device to the delivery tube in a first compressed configuration through a coupling union comprising a series of connectors. The series of connectors may include a stretch resistant member through which the bead is attached to an anchor inside the therapeutic device. The anchor, in turn, may be disposed against a thermally responsive element comprised of a polymeric material configured to melt or otherwise change configuration to release the anchor, and with it, to also release the therapeutic device. Energy may be supplied to the thermally responsive element through electrical conductors and a resistive heating element disposed within the delivery tube.

摘要翻译： 本文提供了一种用于分离治疗装置的系统和方法，例如， 来自患者体内目标部位的输送管的栓塞线圈。 该系统包括靠近治疗装置的远端设置的胎圈，其通过包括一系列连接器的联接联接器将治疗装置以第一压缩构型保持在输送管上。 所述一系列连接器可以包括抗拉构件，所述胎圈通过所述抗拉构件附接到所述治疗装置内的锚固件。 锚固件又可以抵靠由热塑性材料组成的热响应元件，所述热响应元件构造成熔化或以其他方式改变构型以释放锚固件，并且与其一起释放治疗装置。 可以通过电导体和布置在输送管内的电阻加热元件将能量提供给热响应元件。