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Patent Agency Ranking
1.发明授权Cationic polymer nanoparticles encapsulating an active ingredients, and the cosmetic composition containing the same 有权包封活性成分的阳离子聚合物纳米颗粒和含有它的化妆品组合物公开(公告)号：US08877217B2
公开(公告)日：2014-11-04
申请号：US12090680
申请日：2006-10-18
Applicant: Yong Jin Kim , Jin Woong Kim , Ju Hee Ryu , Jong Won Shim , Jun Oh Kim , Ih Seop Chang
Inventor： Yong Jin Kim , Jin Woong Kim , Ju Hee Ryu , Jong Won Shim , Jun Oh Kim , Ih Seop Chang
IPC: A61K8/11
CPC classification number: A61K8/11 , A61K8/671 , A61K8/8152 , A61K8/85 , A61K2800/413 , A61K2800/5426 , A61Q19/00 , C08F220/18 , C08F220/34 , C08G63/6852 , C08F2220/1825
Abstract: Disclosed herein are cationic polymer nanocapsules encapsulating an oil-soluble active ingredient, and a cosmetic composition containing the same. The cationic polymer nanocapsules have a molecular weight of 5,000-100,000, a surface potential of 5-100 mV and a particle size of 50-500 nm. Also, disclosed is a cosmetic composition containing said cationic polymer nanocapsules.
Abstract translation: 本文公开了包封油溶性活性成分的阳离子聚合物纳米胶囊和含有它们的化妆品组合物。 阳离子聚合物纳米胶囊的分子量为5,000-100,000，表面电位为5-100mV，粒度为50-500nm。 还公开了含有所述阳离子聚合物纳米胶囊的化妆品组合物。
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公开(公告)号：US20100184955A1
公开(公告)日：2010-07-22
申请号：US12355833
申请日：2009-01-19
Applicant: Sang-Yoon Kim , Beom-Suk Lee , Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyng Kim , Ju-Hee Ryu , Seul-Ki Lee
Inventor： Sang-Yoon Kim , Beom-Suk Lee , Ick-Chan Kwon , Kui-Won Choi , Kwang-Meyng Kim , Ju-Hee Ryu , Seul-Ki Lee
IPC: C07K14/76
Abstract: Provided is an anticancer prodrug sensitive to a target protease. The anticancer prodrug includes an anticancer drug, peptide that is specifically decomposed by the target protease excessively secreted by cancer cells, and a polymer that is specifically accumulated at a target cancer site. When the inactive anticancer prodrug is administered, the anticancer prodrug is accumulated at the target caner site and then the peptide is decomposed by irradiation of radioactive rays, thereby releasing an active anticancer drug at the target caner site. Accordingly, destruction of normal cells can be minimized and a high anticancer therapeutic effect can be obtained by using a small amount of the anticancer drug administered and a small amount of radioactive rays irradiated.
Abstract translation: 提供对靶蛋白酶敏感的抗癌药物。 抗癌药物包括抗癌药物，被癌细胞过度分泌的靶蛋白酶特异性分解的肽以及特异性聚集在靶癌部位的聚合物。 当施用无活性抗癌前药时，抗癌前药在靶标位点处积聚，然后通过放射线照射分解肽，从而在靶标位点释放活性抗癌药物。 因此，通过使用少量施用的抗癌药物和少量的放射线照射，可以使正常细胞的破坏最小化，可以获得高抗癌治疗效果。
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3.发明申请ANTICANCER PRODRUG ACTIVATED BY RADIATION OR ULTRAVIOLET TREATMENT AND USE THEREOF 有权通过辐射或超紫外线治疗及其使用活化的抗癌药物公开(公告)号：US20130338422A1
公开(公告)日：2013-12-19
申请号：US14001745
申请日：2011-03-02
Applicant: Ju-Hee Ryu , Kwang-Meyung Kim , Ick-Chan Kwon , Kui-Won Choi , Sang-Yoon Kim , Beom-Suk Lee , Dae-Yoon Chi , Hee-Seup Kil , Hyun-Ju Sung
Inventor： Ju-Hee Ryu , Kwang-Meyung Kim , Ick-Chan Kwon , Kui-Won Choi , Sang-Yoon Kim , Beom-Suk Lee , Dae-Yoon Chi , Hee-Seup Kil , Hyun-Ju Sung
CPC classification number: A61K41/0042 , A61K31/704 , A61K38/00 , A61K47/64 , A61N5/062 , A61N5/1001
Abstract: The present invention relates to an anticancer prodrug consisting of peptide of acetyl-SEQ ID NO: 1-linker-anticancer drug. The anticancer prodrug effectively provides an anticancer drug unstable in acid or base, such as doxorubicin, in a form of prodrug. Thus, the anticancer prodrug exists as a non-toxic inactive form when administered into the body, but effectively releases the anticancer drug as an active ingredient in the target area in the presence of caspase activated by radiation or UV treatment after administered into the body. Accordingly, the anticancer drug exhibits selective anticancer effects on cancer cells, thereby maximizing the therapeutic effect and minimizing the side-effects of chemotherapy.
Abstract translation: 本发明涉及一种由乙酰基-SEQ ID NO.1-接头 - 抗癌药物的肽组成的抗癌药物。 抗癌前药有效地提供了在酸或碱中不稳定的抗癌药物，例如以前药形式的多柔比星。 因此，当施用于体内时，抗癌前药以无毒无活性形式存在，但在施用于体内后，通过辐射或UV治疗活化的半胱天冬酶存在下，有效地将抗癌药物作为活性成分释放到目标区域。 因此，抗癌药物对癌细胞具有选择性的抗癌作用，从而最大化治疗效果并使化疗的副作用最小化。
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4.发明授权Anticancer prodrug activated by radiation or ultraviolet treatment and use thereof 有权通过辐射或紫外线处理活化的抗癌前药及其用途公开(公告)号：US09408910B2
公开(公告)日：2016-08-09
申请号：US14001745
申请日：2011-03-02
Applicant: Ju-Hee Ryu , Kwang-Meyung Kim , Ick-Chan Kwon , Kui-Won Choi , Sang-Yoon Kim , Beom-Suk Lee , Dae-Yoon Chi , Hee-Seup Kil , Hyun-Ju Sung
Inventor： Ju-Hee Ryu , Kwang-Meyung Kim , Ick-Chan Kwon , Kui-Won Choi , Sang-Yoon Kim , Beom-Suk Lee , Dae-Yoon Chi , Hee-Seup Kil , Hyun-Ju Sung
CPC classification number: A61K41/0042 , A61K31/704 , A61K38/00 , A61K47/64 , A61N5/062 , A61N5/1001
Abstract: The present invention relates to an anticancer prodrug consisting of peptide of acetyl-SEQ ID NO: 1-linker-anticancer drug. The anticancer prodrug effectively provides an anticancer drug unstable in acid or base, such as doxorubicin, in a form of prodrug. Thus, the anticancer prodrug exists as a non-toxic inactive form when administered into the body, but effectively releases the anticancer drug as an active ingredient in the target area in the presence of caspase activated by radiation or UV treatment after administered into the body. Accordingly, the anticancer drug exhibits selective anticancer effects on cancer cells, thereby maximizing the therapeutic effect and minimizing the side-effects of chemotherapy.
Abstract translation: 本发明涉及一种由乙酰基-SEQ ID NO.1-接头 - 抗癌药物的肽组成的抗癌药物。 抗癌前药有效地提供了在酸或碱中不稳定的抗癌药物，例如以前药形式的多柔比星。 因此，当施用于体内时，抗癌前药以无毒无活性形式存在，但在施用于体内后，通过辐射或UV治疗活化的半胱天冬酶存在下，有效地将抗癌药物作为活性成分释放到目标区域。 因此，抗癌药物对癌细胞具有选择性的抗癌作用，从而最大化治疗效果并使化疗的副作用最小化。
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5.发明申请Cationic Polymer Nanoparticles Encapsulating An Active Ingredients, And The Cosmetic Composition Containing The Same 有权封装活性成分的阳离子聚合物纳米颗粒，以及含有它的化妆品组合物公开(公告)号：US20080268035A1
公开(公告)日：2008-10-30
申请号：US12090680
申请日：2006-10-18
Applicant: Yong Jin Kim , Jin Woong Kim , Ju Hee Ryu , Jong Won Shim , Jun Oh Kim , Ih Seop Chang
Inventor： Yong Jin Kim , Jin Woong Kim , Ju Hee Ryu , Jong Won Shim , Jun Oh Kim , Ih Seop Chang
IPC: A61K9/51 , A61K31/122 , A61K8/72
CPC classification number: A61K8/11 , A61K8/671 , A61K8/8152 , A61K8/85 , A61K2800/413 , A61K2800/5426 , A61Q19/00 , C08F220/18 , C08F220/34 , C08G63/6852 , C08F2220/1825
Abstract: Disclosed herein are cationic polymer nanocapsules encapsulating an oil-soluble active ingredient, and a cosmetic composition containing the same. The cationic polymer nanocapsules have a molecular weight of 5,000-100,000, a surface potential of 5-100 mV and a particle size of 50-500 nm. Also, disclosed is a cosmetic composition containing said cationic polymer nanocapsules.
Abstract translation: 本文公开了包封油溶性活性成分的阳离子聚合物纳米胶囊和含有它们的化妆品组合物。 阳离子聚合物纳米胶囊的分子量为5,000-100,000，表面电位为5-100mV，粒度为50-500nm。 还公开了含有所述阳离子聚合物纳米胶囊的化妆品组合物。
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