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公开(公告)号：US09693957B2
公开(公告)日：2017-07-04
申请号：US14131575
申请日：2012-07-09
IPC分类号： A61K51/00 , A61M36/14 , A61K9/127 , A61K9/14 , A61K9/00 , A61K9/51 , A61K47/48 , A61K31/663 , A61K31/675 , A61K49/00 , A61K51/12
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/14 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K31/663 , A61K31/675 , A61K47/6929 , A61K49/00 , A61K51/1244
摘要： Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone-resorption-related diseases, osteoporosis, Paget's disease, and bone metastases) and as imaging agents.
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2.发明申请METAL BISPHOSPHONATE NANOPARTICLES FOR ANTI-CANCER THERAPY AND IMAGING AND FOR TREATING BONE DISORDERS 有权用于抗癌治疗和成像和治疗骨质疏松症的金属二磷酸钠纳米颗粒公开(公告)号：US20140234210A1
公开(公告)日：2014-08-21
申请号：US14131575
申请日：2012-07-09
IPC分类号： A61K9/51 , A61K49/00 , A61K51/12 , A61K31/675 , A61K9/127 , A61K31/663
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/14 , A61K9/5115 , A61K9/5123 , A61K9/5146 , A61K31/663 , A61K31/675 , A61K47/6929 , A61K49/00 , A61K51/1244
摘要： Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone-resorption-related diseases, osteoporosis, Paget's disease, and bone metastases) and as imaging agents.
摘要翻译： 公开了金属 - 二膦酸盐纳米颗粒。 还公开了包括金属 - 二膦酸盐纳米颗粒的药物组合物，制备金属 - 二膦酸盐纳米颗粒的方法和包含纳米颗粒的材料，以及使用该组合物治疗癌症或骨相关疾病（例如骨吸收相关疾病， 骨质疏松症，佩吉特氏病和骨转移）和成像剂。
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