公开(公告)号：US07196089B2

公开(公告)日：2007-03-27

申请号：US10766030

申请日：2004-01-29

申请人： Alexander W. Oxford ,  Richard J. Davis ,  Robert A. Coleman ,  Kenneth L. Clark ,  David E. Clark ,  Neil V. Harris ,  Garry Fenton ,  George Hynd ,  Keith A. J. Stuttle ,  Jonathan M. Sutton ,  Christopher G. Newton

发明人： Alexander W. Oxford ,  Richard J. Davis ,  Robert A. Coleman ,  Kenneth L. Clark ,  David E. Clark ,  Neil V. Harris ,  Garry Fenton ,  George Hynd ,  Keith A. J. Stuttle ,  Jonathan M. Sutton ,  Christopher G. Newton

IPC分类号： A61K31/341 ,  A61K31/443 ,  A61K31/506 ,  C07D239/34 ,  C07D405/10 ,  C07D307/91 ,  C07D307/68

CPC分类号： C07D307/54 ,  A61K31/34 ,  A61K31/341 ,  A61K31/4155 ,  A61K31/443 ,  C07D307/64 ,  C07D307/68 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): or (iii) a group of formula (III):  wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; (iv) tetrazol-5-yl.

摘要翻译： 式（I）的化合物：

公开(公告)号：US07528157B2

公开(公告)日：2009-05-05

申请号：US11615024

申请日：2006-12-22

申请人： Alexander W. Oxford ,  Richard J. Davis ,  Robert A. Coleman ,  Kenneth L. Clark ,  David E. Clark ,  Neil V. Harris ,  Garry Fenton ,  George Hynd ,  Keith A. J. Stuttle ,  Jonathan M. Sutton ,  Christopher G. Newton

发明人： Alexander W. Oxford ,  Richard J. Davis ,  Robert A. Coleman ,  Kenneth L. Clark ,  David E. Clark ,  Neil V. Harris ,  Garry Fenton ,  George Hynd ,  Keith A. J. Stuttle ,  Jonathan M. Sutton ,  Christopher G. Newton

IPC分类号： C07D307/68 ,  C07D405/10 ,  A61K31/34 ,  A61K31/443

CPC分类号： C07D307/54 ,  A61K31/34 ,  A61K31/341 ,  A61K31/4155 ,  A61K31/443 ,  C07D307/64 ,  C07D307/68 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; (iv) tetrazol-5-yl.

摘要翻译： 式（I）化合物：其中：R2是H或任选取代的C 1-4烷基; Y是 - （CH 2）n X-，其中n是1或2，X是O，S，S（-O），S（-O）2或NRN1，其中RN1选自H或任选取代的C1- 4烷基或Y是-C（-O）NRN 2 - ，其中RN 2选自H，和任选取代的C 1-7烷基或C 5-20芳基; R3是与另外任意取代的C 6芳基连接的任意取代的C6芳基，其中如果两个C 6芳基都是苯环，则两个环之间可能有一个氧桥，与两个环上的连接相邻; A是单键或C1-3亚烷基; 并且R 5是：（i）羧基; （ii）式（II）的基团：（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5-20芳基或NRN 3 R N 4，其中RN 3和RN 4独立地选自任选取代的C 1 -4-烷基; （ⅳ）四唑-5-基。

公开(公告)号：US07858644B2

公开(公告)日：2010-12-28

申请号：US12360954

申请日：2009-01-28

申请人： Alexander W. Oxford ,  Richard J. Davis ,  Robert A. Coleman ,  Kenneth L. Clark ,  David E. Clark ,  Neil V. Harris ,  Garry Fenton ,  George Hynd ,  Keith A. J. Stuttle ,  Jonathan M. Sutton ,  Christopher G. Newton

发明人： Alexander W. Oxford ,  Richard J. Davis ,  Robert A. Coleman ,  Kenneth L. Clark ,  David E. Clark ,  Neil V. Harris ,  Garry Fenton ,  George Hynd ,  Keith A. J. Stuttle ,  Jonathan M. Sutton ,  Christopher G. Newton

IPC分类号： A61K31/4418 ,  A61K31/422 ,  A61K31/34

CPC分类号： C07D307/54 ,  A61K31/34 ,  A61K31/341 ,  A61K31/4155 ,  A61K31/443 ,  C07D307/64 ,  C07D307/68 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): or (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted alkyl; (iv) tetrazol-5-yl.

摘要翻译： 式（I）化合物：其中：R2是H或任选取代的C 1-4烷基; Y是 - （CH 2）n -X-，其中n是1或2，X是O，S，S（= O），S（= O）2或NRN1，其中RN1选自H或任选取代 C 1-4烷基或Y是-C（= O）NRN 2 - ，其中RN 2选自H和任选取代的C 1-7烷基或C 5-20芳基; R3是与另外任意取代的C 6芳基连接的任意取代的C6芳基，其中如果两个C 6芳基都是苯环，则两个环之间可能有一个氧桥，与两个环上的连接相邻; A是单键或C1-3亚烷基; 并且R 5是：（i）羧基; （ii）式（II）的基团：或（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5-20芳基或NRN 3 R N 4，其中RN 3和RN 4独立地选自任选取代的 烷基; （ⅳ）四唑-5-基。

公开(公告)号：US07507754B2

公开(公告)日：2009-03-24

申请号：US11889570

申请日：2007-08-14

申请人： Alexander W. Oxford ,  Richard J. Davis ,  Robert A. Coleman ,  Kenneth L. Clark ,  David E. Clark ,  Neil V. Harris ,  Garry Fenton ,  George Hynd ,  Keith A. J. Stuttle ,  Jonathan M. Sutton ,  Christopher G. Newton

发明人： Alexander W. Oxford ,  Richard J. Davis ,  Robert A. Coleman ,  Kenneth L. Clark ,  David E. Clark ,  Neil V. Harris ,  Garry Fenton ,  George Hynd ,  Keith A. J. Stuttle ,  Jonathan M. Sutton ,  Christopher G. Newton

IPC分类号： A61K31/443 ,  A61K31/343 ,  A61K31/341 ,  C07D405/12 ,  C07D307/91 ,  C07D307/68

CPC分类号： C07D307/54 ,  A61K31/34 ,  A61K31/341 ,  A61K31/4155 ,  A61K31/443 ,  C07D307/64 ,  C07D307/68 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted C1-4 alkyl; (iv) tetrazol-5-yl.

公开(公告)号：US20090143437A1

公开(公告)日：2009-06-04

申请号：US12360954

申请日：2009-01-28

申请人： Alexander W. Oxford ,  Richard J. Davis ,  Robert A. Coleman ,  Kenneth L. Clark ,  David E. Clark ,  Neil V. Harris ,  Garry Fenton ,  George Hynd ,  Keith A.J. Stuttle ,  Jonathan M. Sutton ,  Christopher G. Newton

发明人： Alexander W. Oxford ,  Richard J. Davis ,  Robert A. Coleman ,  Kenneth L. Clark ,  David E. Clark ,  Neil V. Harris ,  Garry Fenton ,  George Hynd ,  Keith A.J. Stuttle ,  Jonathan M. Sutton ,  Christopher G. Newton

IPC分类号： A61K31/341 ,  A61K31/422 ,  A61K31/443 ,  A61P25/00

CPC分类号： C07D307/54 ,  A61K31/34 ,  A61K31/341 ,  A61K31/4155 ,  A61K31/443 ,  C07D307/64 ,  C07D307/68 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Compounds of formula (X): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected from H or optionally substituted C1-4 alkyl, or Y is —C(═O)NRN2—, where RN2 is selected from H, and optionally substituted C1-7 alkyl or C5-20 aryl; R3 is an optionally substituted C6 aryl group linked to a further optionally substituted C6 aryl group, wherein if both C6 aryl groups are benzene rings, there may be an oxygen bridge between the two rings, bound adjacent the link on both rings; A is a single bond or a C1-3 alkylene group; and R5 is either: (i) carboxy; (ii) a group of formula (II): or (iii) a group of formula (III): wherein R is optionally substituted C1-7 alkyl, C5-20 aryl or NRN3RN4, where RN3 and RN4 are independently selected from optionally substituted alkyl; (iv) tetrazol-5-yl.

摘要翻译： 式（X）的化合物：其中：R 2为H或任选取代的C 1-4烷基; Y是 - （CH 2）n X-，其中n是1或2，X是O，S，S（-O），S（-O）2或NRN1，其中RN1选自H或任选取代的C1- 4烷基或Y是-C（-O）NRN 2 - ，其中RN 2选自H，和任选取代的C 1-7烷基或C 5-20芳基; R3是与另外任意取代的C 6芳基连接的任意取代的C6芳基，其中如果两个C 6芳基都是苯环，则两个环之间可能有一个氧桥，与两个环上的连接相邻; A是单键或C1-3亚烷基; 并且R 5是：（i）羧基; （ii）式（II）的基团：或（iii）式（III）的基团：其中R是任选取代的C 1-7烷基，C 5-20芳基或NRN 3 R N 4，其中RN 3和RN 4独立地选自任选取代的 烷基; （ⅳ）四唑-5-基。