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![Process for {3-[2(R)-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid](/abs-image/US/2011/03/29/US07915407B2/abs.jpg.150x150.jpg)
1.发明授权Process for {3-[2(R)-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid 有权{3- [2（R） - [（1R）-1- [3,5-双（三氟甲基）苯基]乙氧基] -3（S） - （4-氟苯基）吗啉-4-基]甲基] -5-氧代-4,5-二氢 - [1,2,4] - 三唑-1-基}膦酸公开(公告)号：US07915407B2
公开(公告)日：2011-03-29
申请号：US12862857
申请日：2010-08-25
IPC分类号： C07D413/06
CPC分类号： C07F9/65583
摘要： The present invention is concerned with a process for the preparation of the compound {3-[2(R)-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl) -morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid, and pharmaceutically acceptable salts thereof. This compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compound is useful e.g., in the treatment of emesis and inflammatory diseases.
摘要翻译： 本发明涉及制备化合物{3- [2（R） - [（1R）-1- [3,5-双（三氟甲基）苯基]乙氧基] -3（S） - （ 4-氟苯基） - 吗啉-4-基]甲基] -5-氧代-4,5-二氢 - [1,2,4] - 三唑-1-基}膦酸及其药学上可接受的盐。 该化合物可用作P物质（神经激肽-1）受体拮抗剂。 特别地，该化合物可用于例如治疗呕吐和炎性疾病。
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公开(公告)号：US07797217B2
公开(公告)日：2010-09-14
申请号：US11564128
申请日：2006-11-28
IPC分类号： G06Q40/00
CPC分类号： G06Q40/06
摘要： A computer system for monitoring and enhancing the collateral security underlying a set of loans is provided, including a system for calculating the unsecured value of the set at any time and for initiating additional collateral enhancement instruments when the unsecured value exceeds a certain limit. The system may include a variety of modules in communication with a relational database for storing data about the loans and system elements. The computer system may also be configured to allocate, manage, and execute the waterfall or cascade of funds between and among the various participants in a financial plan. The invention also includes a structured finance plan and related methods for enhancing the collateral security of a loan obtained for a life insurance or annuity product, and a system and method for managing a portfolio of such loans in order to obtain favorable financing and to facilitate securitization.
摘要翻译： 提供了一个用于监测和增强一系列贷款的抵押担保的计算机系统，包括用于随时计算该组合的无担保价值的系统，以及在无担保价值超过一定限额时启动附加抵押增值工具。 系统可以包括与用于存储关于贷款和系统元件的数据的关系数据库通信的各种模块。 计算机系统还可以被配置为在财务计划中的各参与者之间和之间分配，管理和执行瀑布或级联的资金。 本发明还包括一种结构性融资计划和相关方法，用于增强人寿保险或年金产品获得的贷款的抵押担保，以及管理此类贷款组合的系统和方法，以获得有利的融资并促进证券化 。
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3.发明授权Process for preparing chiral dipeptidyl peptidase-IV inhibitor intermediates 有权制备手性二肽基肽酶-IV抑制剂中间体的方法公开(公告)号：US07902376B2
公开(公告)日：2011-03-08
申请号：US12321533
申请日：2009-01-22
申请人： Feng Xu , Mary M. Kim , Yoshinori Kohmura , Tricia Sladicka , Jonathan D. Rosen , Michael J. Zacuto
发明人： Feng Xu , Mary M. Kim , Yoshinori Kohmura , Tricia Sladicka , Jonathan D. Rosen , Michael J. Zacuto
IPC分类号： C07D498/04 , C07D487/04 , C07D309/10
CPC分类号： C07C271/16 , C07C269/06 , C07C271/18 , C07C271/22 , C07D309/10 , C07D309/30 , C07D487/04 , C07D498/04 , Y02P20/55
摘要： A novel process is provided for the preparation of chiral trans-2,3-disubstituted 5-oxotetrahydropyrans of structural formula (I): wherein Ar is optionally substituted phenyl and P is a primary amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.
摘要翻译： 提供了一种制备结构式（I）的手性反式-2,3-二取代的5-氧代四氢吡喃的新方法：其中Ar是任选取代的苯基，P是伯胺保护基。 这些化合物可用于合成用于治疗2型糖尿病的二肽基肽酶-IV抑制剂。 还提供了从该方法获得的有用的中间体。
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公开(公告)号：US20100324287A1
公开(公告)日：2010-12-23
申请号：US12862857
申请日：2010-08-25
IPC分类号： C07D413/06
CPC分类号： C07F9/65583
摘要： The present invention is concerned with a process for the preparation of the compound {3-[2(R)-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)-morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid, and pharmaceutically acceptable salts thereof. This compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compound is useful e.g., in the treatment of emesis and inflammatory diseases.
摘要翻译： 本发明涉及制备化合物{3- [2（R） - [（1R）-1- [3,5-双（三氟甲基）苯基]乙氧基] -3（S） - （ 4-氟苯基） - 吗啉-4-基]甲基] -5-氧代-4,5-二氢 - [1,2,4] - 三唑-1-基}膦酸及其药学上可接受的盐。 该化合物可用作P物质（神经激肽-1）受体拮抗剂。 特别地，该化合物可用于例如治疗呕吐和炎性疾病。
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5.发明申请公开(公告)号：US20080249809A1
公开(公告)日：2008-10-09
申请号：US10571969
申请日：2005-08-08
IPC分类号： G06Q40/00
CPC分类号： G06Q40/00 , G06Q40/025 , G06Q40/06 , G06Q40/08
摘要： A computer system for monitoring and enhancing the collateral security underlying a set of loans is provided, including a system for calculating the unsecured value of the set at any time and for initialing additional collateral enhancement instruments when the unsecured value exceeds a certain limit. The system may include a variety of modules in communication with a relational database for storing data about the loans and system elements. The computer system may also be configured to allocate, manage, and execute the waterfall or cascade of funds between and among the various participants in a financial plan. The invention also includes a structured finance plan and related methods for enhancing the collateral security of a loan obtained for a life insurance or annuity product, and a system and method for managing a portfolio of such loans in order to obtain favorable financing and to facilitate securitization.
摘要翻译： 提供了一个用于监测和增强一系列贷款的抵押担保的计算机系统，包括用于随时计算该组合的无担保价值的系统，以及在无担保价值超过一定限额时启动附加抵押增值工具。 系统可以包括与用于存储关于贷款和系统元件的数据的关系数据库通信的各种模块。 计算机系统还可以被配置为在财务计划中的各参与者之间和之间分配，管理和执行瀑布或级联的资金。 本发明还包括一种结构性融资计划和相关方法，用于增强人寿保险或年金产品获得的贷款的抵押担保，以及管理此类贷款组合的系统和方法，以获得有利的融资并促进证券化 。
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6.发明授权公开(公告)号：US06538134B2
公开(公告)日：2003-03-25
申请号：US09877839
申请日：2001-06-08
申请人： Louis S. Crocker , Karel M. Jos Brands , Todd D. Nelson , Philip J. Pye , Jonathan D. Rosen , Kai Rossen
发明人： Louis S. Crocker , Karel M. Jos Brands , Todd D. Nelson , Philip J. Pye , Jonathan D. Rosen , Kai Rossen
IPC分类号： C07D26532
CPC分类号： C07D263/04 , C07D265/32
摘要： The present invention is concerned with 4-benzyl-2-hydroxy-1,4-oxazin-3-one, and novel processes for the preparation therof. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.
摘要翻译： 本发明涉及4-苄基-2-羟基-1,4-恶嗪-3-酮及其制备方法。 该化合物可用作合成具有药理活性的化合物的中间体。
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公开(公告)号：US07797218B2
公开(公告)日：2010-09-14
申请号：US11564149
申请日：2006-11-28
IPC分类号： G06Q40/00
CPC分类号： G06Q40/00 , G06Q40/025 , G06Q40/06 , G06Q40/08
摘要： A computer system for monitoring and enhancing the collateral security underlying a set of loans is provided, including a system for calculating the unsecured value of the set at any time and for initiating additional collateral enhancement instruments when the unsecured value exceeds a certain limit. The system may include a variety of modules in communication with a relational database for storing data about the loans and system elements. The computer system may also be configured to allocate, manage, and execute the waterfall or cascade of funds between and among the various participants in a financial plan. The invention also includes a structured finance plan and related methods for enhancing the collateral security of a loan obtained for a life insurance or annuity product, and a system and method for managing a portfolio of such loans in order to obtain favorable financing and to facilitate securitization.
摘要翻译： 提供了一个用于监测和增强一系列贷款的抵押担保的计算机系统，包括用于随时计算该组合的无担保价值的系统，以及在无担保价值超过一定限额时启动附加抵押增值工具。 系统可以包括与用于存储关于贷款和系统元件的数据的关系数据库通信的各种模块。 计算机系统还可以被配置为在财务计划中的各参与者之间和之间分配，管理和执行瀑布或级联的资金。 本发明还包括一种结构性融资计划和相关方法，用于增强人寿保险或年金产品获得的贷款的抵押担保，以及管理此类贷款组合的系统和方法，以获得有利的融资并促进证券化 。
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公开(公告)号：US20080126267A1
公开(公告)日：2008-05-29
申请号：US11564128
申请日：2006-11-28
IPC分类号： G06Q40/00
CPC分类号： G06Q40/06
摘要： A computer system for monitoring and enhancing the collateral security underlying a set of loans is provided, including a system for calculating the unsecured value of the set at any time and for initiating additional collateral enhancement instruments when the unsecured value exceeds a certain limit. The system may include a variety of modules in communication with a relational database for storing data about the loans and system elements. The computer system may also be configured to allocate, manage, and execute the waterfall or cascade of funds between and among the various participants in a financial plan. The invention also includes a structured finance plan and related methods for enhancing the collateral security of a loan obtained for a life insurance or annuity product, and a system and method for managing a portfolio of such loans in order to obtain favorable financing and to facilitate securitization.
摘要翻译： 提供了一个用于监测和增强一系列贷款的抵押担保的计算机系统，包括用于随时计算该组合的无担保价值的系统，以及在无担保价值超过一定限额时启动附加抵押增值工具。 系统可以包括与用于存储关于贷款和系统元件的数据的关系数据库通信的各种模块。 计算机系统还可以被配置为在财务计划中的各参与者之间和之间分配，管理和执行瀑布或级联的资金。 本发明还包括一种结构性融资计划和相关方法，用于增强人寿保险或年金产品获得的贷款的抵押担保，以及管理此类贷款组合的系统和方法，以获得有利的融资并促进证券化 。
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![Process for {3-[2(R)-[(1R)-1-[3,5-bis(trifluoromethyl) phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid](/abs-image/US/2010/10/05/US07807829B2/abs.jpg.150x150.jpg)
9.发明授权Process for {3-[2(R)-[(1R)-1-[3,5-bis(trifluoromethyl) phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid 有权{3- [2（R） - [（1R）-1- [3,5-双（三氟甲基）苯基]乙氧基] -3（S） - （4-氟苯基）吗啉-4-基]甲基] -5-氧代-4,5-二氢 - [1,2,4] - 三唑-1-基}膦酸公开(公告)号：US07807829B2
公开(公告)日：2010-10-05
申请号：US11667001
申请日：2005-11-03
IPC分类号： C07D413/06
CPC分类号： C07F9/65583
摘要： The present invention is concerned with a process for the preparation of the compound {3-[2(R)-[(1R)-1-[3,5-bis(tri-fluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)-morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-[1,2,4]-triazol-1-yl}phosphonic acid, and pharmaceutically acceptable salts thereof. This compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compound is useful e.g., in the treatment of emesis and inflammatory diseases.
摘要翻译： 本发明涉及制备化合物{3- [2（R） - [（1R）-1- [3,5-双（三氟甲基）苯基]乙氧基] -3（S） - （4-氟苯基） - 吗啉-4-基]甲基] -5-氧代-4,5-二氢 - [1,2,4] - 三唑-1-基}膦酸及其药学上可接受的盐。 该化合物可用作P物质（神经激肽-1）受体拮抗剂。 特别地，该化合物可用于例如治疗呕吐和炎性疾病。
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公开(公告)号：US07797214B2
公开(公告)日：2010-09-14
申请号：US10571969
申请日：2005-08-08
IPC分类号： G06Q40/00
CPC分类号： G06Q40/00 , G06Q40/025 , G06Q40/06 , G06Q40/08
摘要： A computer system for monitoring and enhancing the collateral security underlying a set of loans is provided, including a system for calculating the unsecured value of the set at any time and for initialing additional collateral enhancement instruments when the unsecured value exceeds a certain limit. The system may include a variety of modules in communication with a relational database for storing data about the loans and system elements. The computer system may also be configured to allocate, manage, and execute the waterfall or cascade of funds between and among the various participants in a financial plan. The invention also includes a structured finance plan and related methods for enhancing the collateral security of a loan obtained for a life insurance or annuity product, and a system and method for managing a portfolio of such loans in order to obtain favorable financing and to facilitate securitization.
摘要翻译： 提供了一个用于监测和增强一系列贷款的抵押担保的计算机系统，包括用于随时计算该组合的无担保价值的系统，以及在无担保价值超过一定限额时启动附加抵押增值工具。 系统可以包括与用于存储关于贷款和系统元件的数据的关系数据库通信的各种模块。 计算机系统还可以被配置为在财务计划中的各参与者之间和之间分配，管理和执行瀑布或级联的资金。 本发明还包括一种结构性融资计划和相关方法，用于增强人寿保险或年金产品获得的贷款的抵押担保，以及管理此类贷款组合的系统和方法，以获得有利的融资并促进证券化 。
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