知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

74 records (took 0.038 seconds)

    GYRASE INHIBITORS
    1.
    发明申请
    GYRASE INHIBITORS 有权
    GYRASE抑制剂

    公开(公告)号：US20130079323A1

    公开(公告)日：2013-03-28

    申请号：US13394985

    申请日：2010-09-10

    Applicant: Christopher J. Creighton ,  Leslie William Tari ,  Zhiyong Chen ,  Mark Hilgers ,  Thanh To Lam ,  Xiaoming Li ,  Michael Trzoss ,  Junhu Zhang ,  John Finn ,  Daniel Bensen

    Inventor： Christopher J. Creighton ,  Leslie William Tari ,  Zhiyong Chen ,  Mark Hilgers ,  Thanh To Lam ,  Xiaoming Li ,  Michael Trzoss ,  Junhu Zhang ,  John Finn ,  Daniel Bensen

    IPC: C07D487/04 ,  C07D471/04 ,  C07D491/048 ,  C07D487/16 ,  C07D513/04

    CPC classification number: C07D519/00 ,  C07D471/04 ,  C07D471/16 ,  C07D487/04 ,  C07D487/16 ,  C07D491/048 ,  C07D513/04

    Abstract: Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth. Compounds of Formula (I), are disclosed: Formula (I), wherein Y is N or CH; Z is N or CR5; R5 is H, a substituted or unsubstituted hydrocarbyl residue (1-3C) containing 0-2 heteroatoms selected from O, S and N, or is an inorganic residue; L is O, S, NR7, or CR8R9; R7 is H or C1-3 alkyl; R8 and R9 are each independently H or C1-3 alkyl; R2 is H, a hydrocarbyl residue (1-40C) containing 0-10 heteroatoms selected from O, S and N optionally substituted with an inorganic residue; R4 is H, an inorganic residue, or a hydrocarbyl residue (1-30C) containing 0-12 heteroatoms selected from O, S and N and containing 0-10 inorganic residues, wherein R5 and R4 together may join to form a fused ring; and R6 is selected from the group consisting of H, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, halo C1-5 alkyl, halo C2-5 alkenyl, halo C2-5 alkynyl, C1-5 hydroxyalkyl, C1-5 alkyl chloride, C2-5 alkenyl chloride, and C2-5 alkynyl chloride; or a pharmaceutically-acceptable salt, ester, or prodrug thereof.

    Abstract translation: 新型促旋酶抑制剂和相关组合物和方法可用于阻止细菌生长。 公开了式（I）的化合物：式（I），其中Y是N或CH; Z为N或CR5; R5是H，含有0-2个选自O，S和N的杂原子的取代或未取代的烃基残基（1-3C），或是无机残基; L是O，S，NR7或CR8R9; R7是H或C1-3烷基; R 8和R 9各自独立地为H或C 1-3烷基; R2是H，含有0-10个选自O，S和N的杂原子的烃基残基（1-40℃），任选被无机残基取代; R4是H，无机残基或含有0-12个选自O，S和N的杂原子并含有0-10个无机残基的烃基残基（1-30C），其中R 5和R 4可以连接形成稠环; 并且R 6选自H，C 1-5烷基，C 2-5烯基，C 2-5炔基，卤代C 1-5烷基，卤素C 2-5烯基，卤代C 2-5炔基，C 1-5羟基烷基，C 1 -5烷基氯，C2-5烯基氯和C2-5炔基氯; 或其药学上可接受的盐，酯或前药。

    OXAZOLIDINONE CONTAINING DIMER COMPOUNDS, COMPOSITIONS AND METHODS TO MAKE AND USE
    2.
    发明申请
    OXAZOLIDINONE CONTAINING DIMER COMPOUNDS, COMPOSITIONS AND METHODS TO MAKE AND USE 有权
    含有二异氰酸酯的化合物，组合物和方法制备和使用

    公开(公告)号：US20100305069A1

    公开(公告)日：2010-12-02

    申请号：US12787293

    申请日：2010-05-25

    Applicant: D. Keith Hester, II ,  Robert J. Duguid ,  John Finn

    Inventor： D. Keith Hester, II ,  Robert J. Duguid ,  John Finn

    IPC: A61K31/675 ,  C07F9/06 ,  A61P31/04

    CPC classification number: C07F9/65583 ,  A61K31/675

    Abstract: Dosage forms or pharmaceutical compositions comprise a compound having the structure of Formula IV: wherein n is a non-negative integer; wherein each Z is an oxazolidinone-containing moiety having antibiotic activity in vivo upon cleaving, wherein M is independently OR1 or NR1R2; wherein R1 and R2 are independently selected from the group consisting of H, an optionally-substituted hydrocarbyl residue or a pharmaceutically acceptable cation; wherein the compound in the dosage form or a pharmaceutical composition is present in an amount effective for treating or preventing an antibacterial infection in a mammalian subject. Methods of preparing and using these dosage forms or pharmaceutical compositions are also disclosed.

    Abstract translation: 剂型或药物组合物包含具有式IV结构的化合物：其中n是非负整数; 其中每个Z是在裂解时在体内具有抗生素活性的含恶唑烷酮的部分，其中M独立地为OR 1或NR 1 R 2; 其中R1和R2独立地选自H，任选取代的烃基残基或药学上可接受的阳离子; 其中剂型中的化合物或药物组合物以有效治疗或预防哺乳动物受试者的抗菌感染的量存在。 还公开了制备和使用这些剂型或药物组合物的方法。

Patent Agency Ranking