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    Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
    4.
    发明授权
    Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage 失效
    用于治疗神经或心血管组织损伤的化合物，方法和药物组合物

    公开(公告)号：US06514983B1

    公开(公告)日：2003-02-04

    申请号：US09145181

    申请日：1998-09-01

    申请人： Jia-He Li ,  Jie Zhang ,  Paul F. Jackson ,  Keith M. Maclin

    发明人： Jia-He Li ,  Jie Zhang ,  Paul F. Jackson ,  Keith M. Maclin

    IPC分类号： A61K3147

    CPC分类号： C07D249/08 ,  A61K31/4741 ,  A61K31/502 ,  A61K31/5025 ,  C07D231/12 ,  C07D233/56 ,  C07D237/32 ,  C07D491/06 ,  C07D495/06

    摘要： This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of the formula: or a pharmaceutically acceptable salt, hydrate, prodrug, or mixtures thereof, wherein Y is alkylhalo, alkyl-CO—G, COG, a direct bond, C═O, O, NR11, or CR8; G is NR11R16, OR9, SR9, or R10; Z is O, S, or NR11; X is NR16, O, S, CR12R13, C═O, a bond, —CR12═CR13—, —C(R12R13)C(R14R15)—, or; Rhd 1, R2, R3, R4, R5, R6, R7, R8, R10, R12, R13, R14, or R15 are independently: hydrogen, halo, alkylhalo, hydroxy, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl group, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, aryl, amino, alkylamino, nitro, nitroso, carboxy, or aralkyl; R9 is hydrogen, hydroxy, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl group, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, aryl, amino, alkylamino, carboxy, or aralkyl; R11 or R16 are independently: hydrogen, halo, alkylhalo, hydroxy, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl group, C3-C8 cycloalkyl, C5-C7 cycloalkenyl, aryl, amino, alkylamino, carboxy, or aralkyl.

    摘要翻译： 本发明涉及化合物，药物组合物和使用下式的化合物或其药学上可接受的盐，水合物，前药或其混合物的方法，其中Y是烷基卤素，烷基-CO-G，COG，直接键，C = O，O，NR11或CR8; G是NR11R16，OR9，SR9或R10; Z是O，S或NR11; X是NR16，O，S，CR12R13，C = O，键，-CR12 = CR13 - ， - C（R 12 R 13）C（R 14 R 15） - 或者; R 1d，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 10，R 12，R 13，R 14或R 15独立地为氢，卤素，烷基卤素 ，羟基，C1-C9直链或支链烷基，C2-C9直链或支链烯基，C3-C8环烷基，C5-C7环烯基，芳基，氨基，烷基氨基，硝基，亚硝基，羧基或芳烷基; R9是氢 ，羟基，C 1 -C 9直链或支链烷基，C 2 -C 9直链或支链烯基，C 3 -C 8环烷基，C 5 -C 7环烯基，芳基，氨基，烷基氨基，羧基或芳烷基; R 11或R 16独立地为氢 卤素，烷基卤素，羟基，C 1 -C 9直链或支链烷基，C C 2 -C 9直链或支链烯基，C 3 -C 8环烷基，C 5 -C 7环烯基，芳基，氨基，烷基氨基，羧基或芳烷基。