公开(公告)号：US06599921B2

公开(公告)日：2003-07-29

申请号：US09934254

申请日：2001-08-21

申请人： Jonathan Martin Schmidt ,  Julie Mercure ,  Jeffry Lawrence Lowell ,  Stefan Kwiatkowski ,  Krzysztof Pupek ,  Shuguang Zhu ,  John Whelan ,  Natalie Lazarowych

发明人： Jonathan Martin Schmidt ,  Julie Mercure ,  Jeffry Lawrence Lowell ,  Stefan Kwiatkowski ,  Krzysztof Pupek ,  Shuguang Zhu ,  John Whelan ,  Natalie Lazarowych

IPC分类号： A61K31445

CPC分类号： C07D295/088 ,  C07D311/80

摘要： Novel non-steroidal estrogen receptor ligands and methods of synthesis are disclosed. The novel molecules are intended for use in therapeutic preparations for the treatment of estrogen receptor related disease states. The compounds specified are tetra-cyclic derivatives and have been shown to be antiproliferative against human estrogen-dependent cancer cells and to have good binding affinity for the estrogen receptor.