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公开(公告)号：US20050153983A1
公开(公告)日：2005-07-14
申请号：US10514860
申请日：2003-05-12
Applicant: Andrea Houghton , Jean Cottney
Inventor： Andrea Houghton , Jean Cottney
IPC: A61K45/00 , A61K31/40 , A61K31/405 , A61K31/407 , A61K31/495 , A61P25/04 , A61P43/00
CPC classification number: A61K31/405 , A61K31/495
Abstract: The invention relates to a combined pharmaceutical preparation comprising an opioid diarylmethyl piperazine compounds and a NSAID. Such a preparation in which the compounds are either given sequentially or simultaneously can be used for the treatment of pain diminishing the side-effects observed in conventional opioid treatments.
Abstract translation: 本发明涉及包含阿片样二芳基甲基哌嗪化合物和NSAID的组合药物制剂。 化合物依次或同时给予的这种制剂可用于治疗降低常规阿片样物质治疗中观察到的副作用的疼痛。
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2.发明申请SYNERGISTIC COMBINATION FOR THE TREATMENT OF PAIN (CANNABINOID RECEPTOR AGONIST AND OPIOID RECEPTOR AGONIST) 审中-公开用于治疗疼痛的协同组合（CANNABINOID受体激动剂和阿片受体激动剂）公开(公告)号：US20090029984A1
公开(公告)日：2009-01-29
申请号：US11995243
申请日：2006-07-06
Applicant: Julia Adam-Worrall , David Robert Hill , Jean Cottney
Inventor： Julia Adam-Worrall , David Robert Hill , Jean Cottney
IPC: A61K31/485 , A61K31/5377 , A61K31/445 , A61K31/135 , A61P29/00
CPC classification number: A61K31/135 , A61K31/137 , A61K31/4468 , A61K31/485 , A61K31/517 , A61K45/06 , A61K2300/00
Abstract: The invention relates to a pharmaceutical dosage form comprising an analgesic combination for simultaneous or sequential use which comprises a peripherally restricted cannabinoid CB1 receptor agonist having a brain Cmax to plasma Cmax ratio of less than 0.1 and an opioid receptor agonist, as well as to a method for treating pain using said pharmaceutical dosage form.
Abstract translation: 本发明涉及一种药物剂型，其包含用于同时或顺序使用的止痛组合物，其包含具有脑C max至血浆C max比小于0.1的外周限制性大麻素CB1受体激动剂和阿片受体激动剂，以及方法 用于使用所述药物剂型治疗疼痛。
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公开(公告)号：US07375106B2
公开(公告)日：2008-05-20
申请号：US10514860
申请日：2003-05-12
Applicant: Andrea Houghton , Jean Cottney
Inventor： Andrea Houghton , Jean Cottney
IPC: A61K31/495
CPC classification number: A61K31/405 , A61K31/495
Abstract: The invention relates to a combined pharmaceutical preparation comprising an opioid diarylmethyl piperazine compounds and a NSAID. Such a preparation in which the compounds are either given sequentially or simultaneously can be used for the treatment of pain diminishing the side-effects observed in conventional opioid treatments.
Abstract translation: 本发明涉及包含阿片样二芳基甲基哌嗪化合物和NSAID的组合药物制剂。 化合物依次或同时给予的这种制剂可用于治疗降低常规阿片样物质治疗中观察到的副作用的疼痛。
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