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    Inhibitors of epoxide hydrolases for the treatment of hypertension
    2.
    发明申请
    Inhibitors of epoxide hydrolases for the treatment of hypertension 审中-公开
    环氧化物水解酶抑制剂治疗高血压

    公开(公告)号：US20060035869A1

    公开(公告)日：2006-02-16

    申请号：US11240444

    申请日：2005-09-29

    申请人： Bruce Hammock ,  Christophe Morisseau ,  Jiang Zheng ,  Marvin Goodrow ,  Tonya Severson ,  James Sanborn

    发明人： Bruce Hammock ,  Christophe Morisseau ,  Jiang Zheng ,  Marvin Goodrow ,  Tonya Severson ,  James Sanborn

    IPC分类号： A61K31/17 ,  A61K31/66

    CPC分类号： A61K31/325 ,  A61K31/00 ,  A61K31/336

    摘要： Biologically stable inhibitors of soluble epoxide hydrolases are provided. The inhibitors can be used, for example, to selectively inhibit epoxide hydrolase in therapeutic applications such as treating inflammation, for use in affinity separations of the epoxide hydrolases, and in agricultural applications. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R1-R4 is hydrogen, R2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R1 and R3 are each independently a substituted or unsubstituted alkyl, haloalkyl, cycloalkyl, aryl, acyl, or heterocyclic, or being a metabolite or degradation product thereof.

    摘要翻译： 提供了生物稳定的可溶性环氧化物水解酶抑制剂。 抑制剂可用于例如在治疗应用中选择性抑制环氧化物水解酶，例如治疗炎症，用于环氧化物水解酶的亲和分离，以及在农业应用中。 用于实施本发明的一类优选的化合物具有式1所示的结构，其中X和Y各自独立地为氮，氧或硫，X可以进一步为碳，R 1， -R 4是氢，当X是氮时，R 2是氢，但当X是硫或氧时，R 2不是存在的，R 4是氢 当Y为氮时，当Y为硫或氧时不存在，R 1和R 3各自独立地为取代或未取代的烷基，卤代烷基，环烷基，芳基，酰基 ，或杂环，或其代谢产物或降解产物。

    Door Handle Arrangement For Vehicles
    3.
    发明申请
    Door Handle Arrangement For Vehicles 有权
    车门安排

    公开(公告)号：US20140367975A1

    公开(公告)日：2014-12-18

    申请号：US14145365

    申请日：2013-12-31

    申请人： James Sanborn ,  Robert Campbell

    发明人： James Sanborn ,  Robert Campbell

    IPC分类号： E05B85/14

    CPC分类号： E05B85/14 ,  E05B81/76 ,  E05B81/77 ,  E05B81/78 ,  E05B85/16 ,  H03K17/955 ,  H03K17/962 ,  H03K17/975 ,  Y10T292/57

    摘要： A door handle arrangement for vehicles including an electrically insulating cover having an outer actuating surface for a user characterised by at least one metal actuating electrode disposed on the inner side of the cover that is on the side of the cover facing away from the actuating surface. The cover is elastically deformable by an actuation in the area of the actuating surface. The arrangement includes at least one sensor electrode that is disposed at a distance from the actuating element and opposite the inner side of the cover, wherein the sensor electrode lies opposite the actuating electrode at least in certain sections so that the distance between actuating electrode and sensor electrode is variable during deformation of the cover in the region of the actuating surface. The arrangement also includes a control and evaluation device which is coupled at least to the sensor electrode to detect a capacitance between sensor electrode and actuating electrode.

    摘要翻译： 一种用于车辆的门把手装置，其包括具有用于使用者的外部致动表面的电绝缘盖，其特征在于，所述至少一个金属致动电极设置在所述盖的内侧上，所述至少一个金属致动电极位于所述盖的背离所述致动表面的一侧上。 盖子通过在致动表面的区域中的致动而弹性变形。 该装置包括至少一个传感器电极，该传感器电极设置在远离致动元件并且与盖的内侧相对的位置处，其中传感器电极至少在某些部分与致动电极相对，使得致动电极和传感器之间的距离 电极在致动表面的区域中的盖变形期间是可变的。 该装置还包括至少耦合到传感器电极以检测传感器电极和致动电极之间的电容的控制和评估装置。