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1.发明申请DUAL CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO SYNTHESIS METHOD 审中-公开使用体外合成方法选择性地将非氨基酸引入蛋白质的双重充电系统公开(公告)号：US20100184134A1
公开(公告)日：2010-07-22
申请号：US12685544
申请日：2010-01-11
申请人： Alexei M. Voloshin , James F. Zawada , Daniel Gold , Christopher James Murray , James Edward Rozzelle , Nathan Uter , Gang Yin
发明人： Alexei M. Voloshin , James F. Zawada , Daniel Gold , Christopher James Murray , James Edward Rozzelle , Nathan Uter , Gang Yin
IPC分类号： C12P21/06
摘要： This invention provides for a novel means of incorporating non-native amino acids into preselected positions of a protein using a cell-free synthesis system. The methods involve the use of non-orthogonal, native isoaccepting sense tRNAs that are encoded by the genetic code. Such methods allow for numerous non-native amino acids to be incorporated through the use of sense codons without having to rely upon orthogonal tRNA-synthetase pairs.
摘要翻译： 本发明提供了使用无细胞合成系统将非天然氨基酸并入蛋白质的预选位置的新方法。 这些方法涉及使用由遗传密码编码的非正交的天然异位感知有义tRNA。 这样的方法允许通过使用有义密码子掺入许多非天然氨基酸，而不必依赖正交的tRNA-合成酶对。
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2.发明申请MONO CHARGING SYSTEM FOR SELECTIVELY INTRODUCING NON-NATIVE AMINO ACIDS INTO PROTEINS USING AN IN VITRO PROTEIN SYNTHESIS SYSTEM 有权使用维生素蛋白合成系统选择性地将非氨基酸引入蛋白质的单收取系统公开(公告)号：US20100184135A1
公开(公告)日：2010-07-22
申请号：US12685795
申请日：2010-01-12
申请人： Alexei M. Voloshin , James F. Zawada , Daniel Gold , Christopher James Murray , James Edward Rozzelle , Nathan Uter , Gang Yin
发明人： Alexei M. Voloshin , James F. Zawada , Daniel Gold , Christopher James Murray , James Edward Rozzelle , Nathan Uter , Gang Yin
摘要： This invention provides for a novel means of incorporating non-native amino acids into preselected positions of a protein using a cell-free synthesis system. The methods involve the use of non-orthogonal, native isoaccepting sense tRNAs that are encoded by the genetic code. Such methods allow for numerous non-native amino acids to be incorporated through the use of sense codons without having to rely upon orthogonal tRNA-synthetase pairs.
摘要翻译： 本发明提供了使用无细胞合成系统将非天然氨基酸并入蛋白质的预选位置的新方法。 这些方法涉及使用由遗传密码编码的非正交的天然异位感知有义tRNA。 这样的方法允许通过使用有义密码子掺入许多非天然氨基酸，而不必依赖正交的tRNA-合成酶对。
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3.发明授权Mono charging system for selectively introducing non-native amino acids into proteins using an in vitro protein synthesis system 有权单体充电系统，用于使用体外蛋白质合成系统选择性地将非天然氨基酸引入蛋白质公开(公告)号：US08778631B2
公开(公告)日：2014-07-15
申请号：US12685795
申请日：2010-01-12
申请人： Alexei M. Voloshin , James F. Zawada , Daniel Gold , Christopher James Murray , James Edward Rozzelle , Nathan Uter , Gang Yin
发明人： Alexei M. Voloshin , James F. Zawada , Daniel Gold , Christopher James Murray , James Edward Rozzelle , Nathan Uter , Gang Yin
摘要： This invention provides for a novel means of incorporating non-native amino acids into preselected positions of a protein using a cell-free synthesis system. The methods involve the use of non-orthogonal, native isoaccepting sense tRNAs that are encoded by the genetic code. Such methods allow for numerous non-native amino acids to be incorporated through the use of sense codons without having to rely upon orthogonal tRNA-synthetase pairs.
摘要翻译： 本发明提供了使用无细胞合成系统将非天然氨基酸并入蛋白质的预选位置的新方法。 这些方法涉及使用由遗传密码编码的非正交的天然异位感知有义tRNA。 这样的方法允许通过使用有义密码子掺入许多非天然氨基酸，而不必依赖正交的tRNA-合成酶对。
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