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1.发明授权公开(公告)号：US08889114B2
公开(公告)日：2014-11-18
申请号：US12934634
申请日：2009-03-19
IPC分类号： A61P9/08 , A61P17/02 , A61K38/18 , A61K31/722
CPC分类号： A61K38/18 , A61K31/722 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K47/36 , C07K14/475
摘要： The present invention refers to the use of growth factors, which are effective on mesothelial cell proliferation, used in a sterilized carboxymethylchitosan pharmaceutical composition employed to reduce postoperative adhesions severity. The present invention also provides a method to inhibit postoperative adhesions severity.
摘要翻译： 本发明涉及用于灭菌的羧甲基壳聚糖药物组合物中用于减少术后粘连严重性的间皮细胞增殖有效的生长因子的用途。 本发明还提供了抑制术后粘连严重性的方法。
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2.发明申请公开(公告)号：US20130217624A1
公开(公告)日：2013-08-22
申请号：US13846455
申请日：2013-03-18
IPC分类号： A61K38/18
CPC分类号： A61K38/18 , A61K31/722 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K47/36 , C07K14/475
摘要： A method of inhibiting postoperative adhesion severity of mammalian tissues. The method includes the application on an operated tissue surface of an effective therapeutic amount of a pharmaceutical composition containing a pharmaceutically acceptable amount of growth factors and sterilized carboxymethylchitosan. A method of inhibiting postoperative adhesion severity that includes the step of applying a composition comprising a growth factor, where the growth factor is used as a modulating factor on mesothelial cell proliferation is also provided.
摘要翻译： 一种抑制哺乳动物组织的术后粘连严重程度的方法。 该方法包括在有效治疗量的药物组合物表面上施用含有药学上可接受量的生长因子和灭菌的羧甲基壳聚糖的药物组合物。 还提供了抑制术后粘连严重性的方法，其包括施用包含生长因子的组合物的步骤，其中生长因子用作间皮细胞增殖的调节因子。
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3.发明申请公开(公告)号：US20110165095A1
公开(公告)日：2011-07-07
申请号：US12934634
申请日：2009-03-19
CPC分类号： A61K38/18 , A61K31/722 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K47/36 , C07K14/475
摘要： The present invention refers to the use of growth factors, which are effective on mesothelial cell proliferation, used in a sterilized carboxymethylchitosan pharmaceutical composition employed to reduce postoperative adhesions severity. The present invention also provides a method to inhibit postoperative adhesions severity.
摘要翻译： 本发明涉及用于灭菌的羧甲基壳聚糖药物组合物中用于减少术后粘连严重性的间皮细胞增殖有效的生长因子的用途。 本发明还提供了抑制术后粘连严重性的方法。
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