公开(公告)号：US09726766B2

公开(公告)日：2017-08-08

申请号：US13989940

申请日：2010-11-29

申请人： Marcus Neuer ,  Yong Kong ,  Ralf Lentering ,  Jürgen Stein

发明人： Marcus Neuer ,  Yong Kong ,  Ralf Lentering ,  Jürgen Stein

IPC分类号： H03F1/26 ,  H04B15/00 ,  G01T1/17 ,  G01V5/00

CPC分类号： G01T1/17 ,  G01V5/0008

摘要： A method for correctly identifying at least one source, in particular at least one nuclide, enclosed in a human body and/or a container, is provided, the method comprising the following steps: detecting and measuring the at least one source by means of a gamma spectroscopic device; identifying, in a first estimation step, the at least one source by means of a standard nuclide identification procedure for evaluating a measured first spectrum of the at least one source; applying a second estimation step on the basis of the result of the first estimation step, wherein the result of the first estimation step is used for acquiring a plurality of second spectra of the at least one source found by the standard nuclide identification procedure for a plurality of absorption scenarios and for a plurality of scattering scenarios; and comparing the measured first spectrum with a scatter and absorber spectrum obtained from the plurality of second spectra generated in the second estimation step.

公开(公告)号：US08212221B2

公开(公告)日：2012-07-03

申请号：US12674932

申请日：2009-02-16

申请人： Jürgen Stein ,  Guntram Pausch ,  Cristina Plettner

发明人： Jürgen Stein ,  Guntram Pausch ,  Cristina Plettner

IPC分类号： G01T1/20

CPC分类号： G01T1/2018

摘要： The invention relates to a detector for measuring nuclear radiation, especially gamma-radiation, comprising a scintillator crystal with a light decay time of less than 100 ns, a silicon drift detector (SDD) for the measurement of both direct hits of low energy radiation and the light, being emitted from the scintillator crystal, the silicon drift detector being mounted between the scintillation crystal and the radiation entry window, a preamplifier, connected to the SDD, electronic devices, being capable of determining the signal rise time of the measured signals and of separating the signals on the basis of said rise time, electronic devices, being capable of separately collecting the energy spectra of SDD and scintillator detection events on the basis of the different rise times.

摘要翻译： 本发明涉及一种用于测量核辐射，特别是伽马辐射的检测器，其包括具有小于100ns的光衰减时间的闪烁体晶体，用于测量低能量辐射的直接命中的硅漂移检测器（SDD）和 从闪烁体晶体发射的光，硅漂移检测器安装在闪烁晶体和辐射入口窗口之间，连接到SDD的电子设备的前置放大器能够确定测量信号的信号上升时间， 基于所述上升时间分离信号的电子设备，能够基于不同的上升时间单独收集SDD的能量谱和闪烁体检测事件。

公开(公告)号：US20120080599A1

公开(公告)日：2012-04-05

申请号：US13376613

申请日：2009-07-27

申请人： Guntram Pausch ,  Claus Michael Herbach ,  Jürgen Stein

发明人： Guntram Pausch ,  Claus Michael Herbach ,  Jürgen Stein

IPC分类号： G01T3/06

CPC分类号： G01T3/06

摘要： An apparatus for detecting neutron radiation includes a first section with a high neutron absorption capability and a second section with a low neutron absorption capability. The second section includes a gamma ray scintillator having an inorganic material with an attenuation length of less than 10 cm for gamma rays of 5 MeV energy. The material of the first section releases the energy deployed in the first section by neutron capture mainly via gamma radiation. A substantial portion of the first section is covered by the second section. An evaluation device determines the amount of light detected by a light detector for one scintillation event, and the amount is in a known relation to the energy deployed by gamma radiation in the second section. The evaluation device classifies detected radiation as neutrons when the measured total gamma energy Esum is above 2,614 MeV.

摘要翻译： 用于检测中子辐射的装置包括具有高中子吸收能力的第一部分和具有低中子吸收能力的第二部分。 第二部分包括对于5MeV能量的γ射线，具有衰减长度小于10cm的无机材料的伽马射线闪烁体。 第一部分的材料通过主要通过γ辐射的中子捕获来释放在第一部分中部署的能量。 第一部分的主要部分由第二部分覆盖。 评估装置确定由一个闪烁事件的光检测器检测到的光量，并且该量与第二部分中由伽马辐射部署的能量已知关系。 当测量的总伽马能量Esum高于2614MeV时，评估装置将检测到的辐射分类为中子。

公开(公告)号：US07642518B1

公开(公告)日：2010-01-05

申请号：US12259111

申请日：2008-10-27

申请人： Jürgen Stein ,  Guntram Pausch

发明人： Jürgen Stein ,  Guntram Pausch

IPC分类号： G01T1/164

CPC分类号： G01T1/40 ,  G01T1/208

摘要： A detector for the measurement of radiation, preferably ionizing radiation, includes a medium, means for the conversion of the radiation energy absorbed by the medium into electrical charge, means for digital sampling of the charge signals, means for the determination of a calibration factor K, and means for the stabilization of the output signals of the detector. The medium at least partly absorbs the radiation to be measured. The electric charge is at least partially proportional to the energy of the radiation. The sampling is done preferably with a sampling rate between 1 and 1000 MHz. Further signal processing is digital. The calibration factor K has a fixed relation with respect to the decay time τ of the medium. The output signals of the detector are mainly proportional to the radiation energy, and are stabilized with the help of the calibration factor K.

摘要翻译： 用于测量辐射，优选电离辐射的检测器包括介质，用于将由介质吸收的辐射能转换成电荷的装置，用于对电荷信号进行数字采样的装置，用于确定校准因子K 以及用于稳定检测器的输出信号的装置。 该介质至少部分地吸收要测量的辐射。 电荷至少部分地与辐射的能量成比例。 采样速率优选在1到1000 MHz之间。 进一步的信号处理是数字的。 校准因子K相对于介质的衰减时间τ具有固定的关系。 检测器的输出信号主要与辐射能成比例，并借助于校准因子K得到稳定。

公开(公告)号：US20070210247A1

公开(公告)日：2007-09-13

申请号：US11568924

申请日：2004-05-10

申请人： Jürgen Stein ,  Guntram Pausch

发明人： Jürgen Stein ,  Guntram Pausch

IPC分类号： G01D18/00

CPC分类号： G01T1/40 ,  G01T1/208

摘要： The invention relates to a method for stabilizing the signals generated by a scintillation detector for measuring radiation, especially ionizing radiation, using the radiation which is at least partially absorbed in the detector, said signals depending on the operating temperature of the detector. According to said method, the temperature-dependent calibration factor K is determined from the signal shape of the signals generated by the radiation to be measured itself.

摘要翻译： 本发明涉及一种用于使用至少部分地被吸收在检测器中的辐射来测量用于测量辐射，特别是电离辐射的闪烁检测器产生的信号的方法，所述信号取决于检测器的工作温度。 根据所述方法，根据由被测量的辐射本身产生的信号的信号形状确定温度依赖性校准因子K.

公开(公告)号：US08008623B2

公开(公告)日：2011-08-30

申请号：US12821449

申请日：2010-06-23

申请人： Jürgen Stein ,  Guntram Pausch ,  Yong Kong

发明人： Jürgen Stein ,  Guntram Pausch ,  Yong Kong

IPC分类号： G01T1/00

CPC分类号： G01T1/17

摘要： A method for linearizing a radiation detector is provided, the method including measuring a pulse height spectrum of a predetermined radiation source, identifying at least one spectrum template for the predetermined radiation source, and determining a linearization function by comparing the measured pulse height spectrum with the at least one identified spectrum template. The at least one spectrum template is a predefined synthesized energy spectrum for the predetermined radiation source and for the corresponding radiation detector. Further, a detector for measuring one or more types of radiation is provided, the detector being adapted for transforming the measured pulse height spectrum in an energy-calibrated spectrum, the transformation including a linearization step, where a linearization function used with the linearization step is determined according to the inventive method.

摘要翻译： 提供了一种用于线性化放射线检测器的方法，该方法包括测量预定辐射源的脉冲高度谱，识别用于预定辐射源的至少一个光谱模板，以及通过将所测量的脉冲高度谱与 至少一个识别的光谱模板。 至少一个光谱模板是用于预定辐射源和对应的辐射探测器的预定的合成能谱。 此外，提供了一种用于测量一种或多种类型的辐射的检测器，所述检测器适于在能量校准的光谱中变换测量的脉冲高度谱，该变换包括线性化步骤，其中线性化步骤使用的线性化函数是 根据本发明的方法测定。

公开(公告)号：US20100200762A1

公开(公告)日：2010-08-12

申请号：US12674932

申请日：2009-02-16

申请人： Jürgen Stein ,  Guntram Pausch ,  Cristina Plettner

发明人： Jürgen Stein ,  Guntram Pausch ,  Cristina Plettner

IPC分类号： G01T1/20

CPC分类号： G01T1/2018

摘要： The invention relates to a detector for measuring nuclear radiation, especially gamma-radiation, comprising a scintillator crystal with a light decay time of less than 100 ns, a silicon drift detector (SDD) for the measurement of both direct hits of low energy radiation and the light, being emitted from the scintillator crystal, the silicon drift detector being mounted between the scintillation crystal and the radiation entry window, a preamplifier, connected to the SDD, electronic devices, being capable of determining the signal rise time of the measured signals and of separating the signals on the basis of said rise time, electronic devices, being capable of separately collecting the energy spectra of SDD and scintillator detection events on the basis of the different rise times.

摘要翻译： 本发明涉及一种用于测量核辐射，特别是伽马辐射的检测器，其包括具有小于100ns的光衰减时间的闪烁体晶体，用于测量低能量辐射的直接命中的硅漂移检测器（SDD）和 从闪烁体晶体发射的光，硅漂移检测器安装在闪烁晶体和辐射入口窗口之间，连接到SDD的电子设备的前置放大器能够确定测量信号的信号上升时间， 基于所述上升时间分离信号的电子设备，能够基于不同的上升时间单独收集SDD的能量谱和闪烁体检测事件。

公开(公告)号：US06892971B2

公开(公告)日：2005-05-17

申请号：US10381622

申请日：2002-05-16

申请人： Franz Rieger ,  Fevzi Yildirim ,  Andreas Eichendorf ,  Günther Hohl ,  Michael Hübel ,  Jürgen Stein

发明人： Franz Rieger ,  Fevzi Yildirim ,  Andreas Eichendorf ,  Günther Hohl ,  Michael Hübel ,  Jürgen Stein

IPC分类号： F02D41/20 ,  F02M51/00 ,  F02M51/06 ,  B05B1/30

CPC分类号： F02M51/0685 ,  F02D41/20 ,  F02D2041/2079 ,  F02M51/0617

摘要： A fuel injector, in particular a fuel injector for fuel-injection systems of internal combustion engines, includes a first magnetic coil cooperating with a first armature, a second magnetic coil cooperating with a second armature, and a valve needle which is in force-locking connection with the first armature via a first flange and to the second armature via a second flange, to actuate a valve-closure member. A restoring spring acts upon the valve needle in a closing direction of the fuel injector. A first positioning spring, situated between the first flange and the first armature, acts upon the first armature in the closing direction of the fuel injector, while a second positioning spring, situated between the second flange and the second armature, acts upon the second armature in an opening direction of the fuel injector.

摘要翻译： 燃料喷射器，特别是用于内燃机燃料喷射系统的燃料喷射器，包括与第一电枢配合的第一电磁线圈，与第二电枢配合的第二电磁线圈，以及与第二电枢相配合的阀针 通过第一凸缘与第一电枢连接，并通过第二凸缘连接到第二电枢，以致动阀闭合构件。 复原弹簧沿着燃料喷射器的关闭方向作用在阀针上。 位于第一凸缘和第一电枢之间的第一定位弹簧在燃料喷射器的关闭方向上作用在第一电枢上，而位于第二凸缘和第二电枢之间的第二定位弹簧作用在第二电枢上 在燃料喷射器的打开方向上。

公开(公告)号：US20120074326A1

公开(公告)日：2012-03-29

申请号：US13376609

申请日：2009-07-27

申请人： Guntram Pausch ,  Claus Michael Herbach ,  Jürgen Stein

发明人： Guntram Pausch ,  Claus Michael Herbach ,  Jürgen Stein

IPC分类号： G01T1/20

CPC分类号： G01T3/06 ,  G01T3/00

摘要： An apparatus for detecting neutron radiation includes a gamma ray scintillator having an inorganic material with an attenuation length Lg of less than 10 cm for gamma rays of 5 MeV energy to provide for high gamma ray stopping power for energetic gamma rays within the -gamma ray scintillator. The gamma ray scintillator includes components with a product of neutron capture cross section and concentration leading to an absorption length Ln for thermal neutrons which is larger than 0.5 cm but smaller than five times the attenuation length Lg for 5 MeV gammas, the gamma ray scintillator having a diameter or edge length of at least 50% of Lg. The apparatus includes an evaluation device to determine the amount of light, detected by a light detector for one scintillation event The evaluation device classifies detected radiation as neutrons when the measured total gamma energy Esum is above 2,614 MeV.

摘要翻译： 用于检测中子辐射的装置包括伽马射线闪烁体，其具有对于5MeV能量的伽马射线具有小于10cm的衰减长度Lg的无机材料，以为γ射线闪烁体内的能量伽马射线提供高伽马射线停止功率 。 伽马射线闪烁体包括具有中子俘获截面积和浓度的乘积的组分，导致热中子的吸收长度Ln大于0.5MeV，但小于5MeV伽马的衰减长度Lg的五倍，伽马射线闪烁体具有 直径或边缘长度至少为Lg的50％。 该装置包括用于确定由一个闪烁事件的光检测器检测到的光量的评估装置。当测量的总伽马能量Esum高于2,614MeV时，评估装置将检测到的辐射分类为中子。

公开(公告)号：US20070243247A1

公开(公告)日：2007-10-18

申请号：US11569581

申请日：2005-05-12

申请人： Jennifer Dressman ,  Hans-Jürgen Stein ,  Thomas Furst ,  Christiane Bott

发明人： Jennifer Dressman ,  Hans-Jürgen Stein ,  Thomas Furst ,  Christiane Bott

IPC分类号： A61K9/16 ,  A61K9/20

CPC分类号： A61K9/5026 ,  A61K31/575

摘要： The invention relates to a dosage form, containing the active ingredient cholylsarcosine, in the form of pellets, which are provided with a polymer coating that is resistant to gastric juices. The invention is characterised in that it discloses pellets comprising an active ingredient, which contain between 50 and 80 wt. % of the active ingredient cholylsarcosine and between 50 and 20 wt. % of one or more conventional pharmaceutical adjuvants as binding agents, whereby at least 90 wt. % of said adjuvants are water-soluble and the size of at least 80 % of the pellets comprising an active ingredient is between 800 and 2,500 $g(m)m. The granulates containing an active ingredient are coated with an anonic, film-forming polymer coating agent, which dissolves in a 0.07M sodium phosphate buffer with a pH value of 5.5 at a dissolution rate of at least 10 mg/min*g and whose dissolution rate in a 0.07M sodium phosphate buffer with a pH value of 6.0 is at least 200 mg/min*g. The polymer coating amounts to between 5 and 15 wt. % of the pellet weight. The invention also relates to a method for producing said dosage form.

摘要翻译： 本发明涉及一种剂型，其含有丸粒形式的活性成分胆甾肌苷，其具有耐胃液的聚合物涂层。 本发明的特征在于它公开了包含活性成分的丸剂，其含有50至80wt。 ％的活性成分胆固醇和50至20wt。 ％的一种或多种常规药物佐剂作为粘合剂，其中至少90wt。 所述佐剂的百分比是水溶性的，并且至少80％的包含活性成分的丸粒的尺寸为800-2,500元（m）m。 含有活性成分的颗粒用无声成膜聚合物涂层剂涂覆，其溶解速率至少为10mg / min * g，溶解于pH值为5.5的0.07M磷酸钠缓冲液中，其溶解度 pH值为6.0的0.07M磷酸钠缓冲液中的速率为至少200mg / min * g。 聚合物涂层为5至15wt。 颗粒重量的百分比。 本发明还涉及生产所述剂型的方法。