公开(公告)号：US20140335066A1

公开(公告)日：2014-11-13

申请号：US14244284

申请日：2014-04-03

申请人： Marika Mikelsaar ,  Epp Songisepp ,  Pirje Hütt ,  Imbi Smidt ,  Kai Truusalu ,  Merle Rätsep ,  Siiri Kõljalg ,  Jelena Stsepetova ,  Kalle Kilk ,  Mihkel Zilmer ,  Epp Sepp ,  Raik-Hiio Mikelsaar

发明人： Marika Mikelsaar ,  Epp Songisepp ,  Pirje Hütt ,  Imbi Smidt ,  Kai Truusalu ,  Merle Rätsep ,  Siiri Kõljalg ,  Jelena Stsepetova ,  Kalle Kilk ,  Mihkel Zilmer ,  Epp Sepp ,  Raik-Hiio Mikelsaar

IPC分类号： A61K35/74 ,  C12N1/20 ,  A23C9/123

CPC分类号： A61K35/747 ,  A23C9/1234 ,  A23C19/054 ,  A23C19/061 ,  A23C19/062 ,  A23K10/18 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/67 ,  A61K31/047 ,  A61K2035/115 ,  C12N1/20 ,  C12R1/25 ,  A23V2200/00 ,  A23V2200/3204 ,  A23V2200/324 ,  A23V2200/326 ,  A23V2200/3262 ,  A23V2250/6422

摘要： A microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L. plantarum Inducia is used for reducing the level of LDL-cholesterol in blood for preventing the cholesterol metabolism disorders and cardiovascular disorders. L. plantarum Inducia enhances simultaneously the natural defense potential and cellular immunity, and as anti-oxidative agent enhances anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL). The strain is also used as an antimicrobial agent for lowering risk of Clostridium difficile associated diarrhoeae (CDAD) by preventing germination of C. difficile spores and by suppressing proliferation of its vegetative cells. The compositions comprising L. plantarum Inducia decrease the levels of LDL-cholesterol and ox-LDL in blood, enhance the natural defense potential and lower risk of CDAD. The composition may further comprise xylitol.

摘要翻译： 用于植物乳杆菌的微生物菌株Inducer DSM 21379，用作降血胆固醇，抗微生物和抗氧化剂以及作为受试者的自然防御潜力的增强剂。 L. plantarum Inducia用于降低血液中的低密度脂蛋白胆固醇水平，以预防胆固醇代谢紊乱和心血管疾病。 植物乳杆菌Inducia同时增强了自然防御潜力和细胞免疫力，抗氧化剂通过降低氧化低密度脂蛋白（ox-LDL）的水平来增强血液的抗氧化活性。 该菌株还可用作抗菌剂，通过预防艰难梭菌孢子的发芽和抑制其营养细胞的增殖来降低艰难梭菌相关性腹泻（CDAD）的风险。 包括植物乳杆菌属植物的组合物降低血液中LDL-胆固醇和ox-LDL的水平，增强自然防御潜力，降低CDAD的风险。 组合物还可以包含木糖醇。

公开(公告)号：US10272122B2

公开(公告)日：2019-04-30

申请号：US15132286

申请日：2016-04-19

申请人： Marika Mikelsaar ,  Epp Songisepp ,  Pirje Hütt ,  Imbi Smidt ,  Kai Truusalu ,  Merle Rätsep ,  Siiri Koljalg ,  Jelena Stsepetova ,  Kalle Kilk ,  Mihkel Zilmer ,  Epp Sepp ,  Raik-Hiio Mikelsaar

发明人： Marika Mikelsaar ,  Epp Songisepp ,  Pirje Hütt ,  Imbi Smidt ,  Kai Truusalu ,  Merle Rätsep ,  Siiri Koljalg ,  Jelena Stsepetova ,  Kalle Kilk ,  Mihkel Zilmer ,  Epp Sepp ,  Raik-Hiio Mikelsaar

IPC分类号： A61K35/747 ,  A23C9/123 ,  C12R1/25 ,  A23L33/135 ,  A23K10/18 ,  A23C19/06 ,  C12N1/20 ,  A23C19/05 ,  A61K35/00 ,  A61K31/047

摘要： A microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L. plantarum Inducia is used for reducing the level of LDL-cholesterol in blood for preventing the cholesterol metabolism disorders and cardiovascular disorders. L. plantarum Inducia enhances simultaneously the natural defense potential and cellular immunity, and as anti-oxidative agent enhances anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL). The strain is also used as an antimicrobial agent for lowering risk of Clostridium difficile associated diarrhea (CDAD) by preventing germination of C. difficile spores and by suppressing proliferation of its vegetative cells. The compositions comprising L. plantarum Inducia decrease the levels of LDL-cholesterol and ox-LDL in blood, enhance the natural defense potential and lower risk of CDAD. The composition may further comprise xylitol.

公开(公告)号：US20110274789A1

公开(公告)日：2011-11-10

申请号：US12992862

申请日：2009-05-12

申请人： Marika Mikelsaar ,  Epp Songisepp ,  Imbi Smidt ,  Jelena Stsepetove ,  Pirje Hutt ,  Mihkel Zilmer ,  Kai Truusalu ,  Kalle Kilk

发明人： Marika Mikelsaar ,  Epp Songisepp ,  Imbi Smidt ,  Jelena Stsepetove ,  Pirje Hutt ,  Mihkel Zilmer ,  Kai Truusalu ,  Kalle Kilk

IPC分类号： C12N1/20 ,  A23C19/00 ,  A23C9/152 ,  A23C9/123

CPC分类号： A61K35/747 ,  A23C9/1234 ,  A23C19/054 ,  A23C19/061 ,  A23C19/062 ,  A23K10/18 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/67 ,  A61K31/047 ,  A61K2035/115 ,  C12N1/20 ,  C12R1/25 ,  A23V2200/00 ,  A23V2200/3204 ,  A23V2200/324 ,  A23V2200/326 ,  A23V2200/3262 ,  A23V2250/6422

摘要： The present invention relates to a microorganism Lactobacillus plantarum strain Inducia DSM 21379 as probiotic, its functional properties, food product (e.g. cheese) and composition comprising said microorganism and use of said microorganism for production of medicine for enhancing cellular immunity. L. plantarum Inducia produces polyamines from ornithine and glutamate, nitric mono-oxide (NO) from arginine, possesses antioxidative activity and with produced polyamines, nitric mono-oxide and antioxidative compounds improves the intestinal barrier function, increases number of immunocytes in blood and induces cytokine production for enhancement of organisms' natural defense.

摘要翻译： 本发明涉及植物乳杆菌菌株Inducer DSM 21379作为益生菌，其功能特性，食品（例如奶酪）和包含所述微生物的组合物以及所述微生物用于生产用于增强细胞免疫的药物的用途。 L. plantarum Inducia从鸟氨酸和谷氨酸生产多胺，来自精氨酸的硝酸一氧化物（NO）具有抗氧化活性，并与产生的多胺，硝酸一氧化物和抗氧化化合物改善肠屏障功能，增加血液中的免疫细胞数量和诱导 细胞因子生产增强生物的自然防御。