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    OPEN ENDED CONTAINER CLOSURE INCLUDING A FLEXIBLE MEMBRANE AND A RIGID CAP
    1.
    发明申请
    OPEN ENDED CONTAINER CLOSURE INCLUDING A FLEXIBLE MEMBRANE AND A RIGID CAP 审中-公开
    开放容器关闭，包括柔性膜和刚性盖

    公开(公告)号：US20080017646A1

    公开(公告)日：2008-01-24

    申请号：US11867135

    申请日：2007-10-04

    Applicant: Ian Baird-Smith ,  Andreas Ziegler ,  Reinhart Geisler ,  Werner Hammon

    Inventor： Ian Baird-Smith ,  Andreas Ziegler ,  Reinhart Geisler ,  Werner Hammon

    IPC: B65D43/02 ,  B65D43/00 ,  B65D51/20

    CPC classification number: B65D51/20 ,  B65D43/0231 ,  B65D2251/0018 ,  B65D2251/0093 ,  B65D2543/00092 ,  B65D2543/00277 ,  B65D2543/00527 ,  B65D2543/00537 ,  B65D2543/00972

    Abstract: The invention concerns a closure for a cylindrical can (10) The closure includes a flexible member (11) of the easy-open type secured across the open end of the can (10). A rigid, screw cap (22) is screwed over the thus sealed end of the can. An annular, resilient member (24) depending downwardly from the underside of the end wall of the cap (22), engages the membrane (11) in the vicinity of the end flange (18) of the can body (10) thereby strengthening the seal between the membrane (11) and the flange (18). This advantageously permits cooking of the contents of the can with the flexible membrane (11) in situ, thereby giving rise to a can having an easy-open end, the contents of which can are cooked and sterilized using conventional processing lines.

    Abstract translation: 本发明涉及一种用于圆柱形罐（10）的封闭件。封闭件包括易于打开的柔性构件（11），该柔性构件固定在罐（10）的开口端上。 将刚性的螺帽（22）拧在罐的如此密封的端部上。 从盖（22）的端壁的下侧向下悬垂的环形弹性构件（24）与罐体（10）的端部凸缘（18）附近的膜（11）接合，从而加强 膜（11）和凸缘（18）之间的密封。 这有利于允许原位使用柔性膜（11）烹饪罐的内容物，从而产生具有易开放端的罐，其内容物可以使用常规加工管线进行烹饪和消毒。

    Process for the synthesis of CXCR4 antagonist
    3.
    发明申请
    Process for the synthesis of CXCR4 antagonist 有权
    合成CXCR4拮抗剂的方法

    公开(公告)号：US20050209277A1

    公开(公告)日：2005-09-22

    申请号：US11077896

    申请日：2005-03-11

    Applicant: Jason Crawford ,  Gang Chen ,  David Gauthier ,  Renato Skerlj ,  Ian Baird ,  Trevor Wilson

    Inventor： Jason Crawford ,  Gang Chen ,  David Gauthier ,  Renato Skerlj ,  Ian Baird ,  Trevor Wilson

    IPC: A61K31/4709 ,  C07D215/38 ,  C07D215/40 ,  C07D401/12 ,  C07D401/14 ,  C07D43/02

    CPC classification number: C07D401/14 ,  C07D215/40 ,  C07D401/12 ,  Y02P20/55

    Abstract: This invention relates to a process for synthesizing heterocyclic pharmaceutical compound which binds to the CXCR4 chemokine receptor. In one embodiment, the process comprises: a) reacting a 5,6,7,8-tetrahydroquinolinylamine and an alkyl aldehyde bearing a phthalimide or a di-tertiary-butoxycarbonyl (di-BOC) protecting group to form an imine; b) reducing the imine to form a secondary amine; c) reacting the secondary amine with a haloalkyl substituted heterocyclic compound, to form a phthalimido-protected or di-tert-butoxycarbonyl protected tertiary amine; and d) hydrolyzing the protected amine to obtain a compound having Formula I′

    Abstract translation: 本发明涉及一种结合CXCR4趋化因子受体的杂环药物化合物的合成方法。 在一个实施方案中，该方法包括：a）使5,6,7,8-四氢喹啉基胺和带有邻苯二甲酰亚胺或二叔丁氧基羰基（二-BOC）保护基团的烷基醛反应以形成亚胺; b）还原亚胺以形成仲胺; c）使仲胺与卤代烷基取代的杂环化合物反应，形成邻苯二甲酰亚氨基保护或二叔丁氧羰基保护的叔胺; 和d）水解受保护的胺以获得具有式I'

    Detection of hypoxia
    7.
    发明申请
    Detection of hypoxia 审中-公开
    检测缺氧

    公开(公告)号：US20050026974A1

    公开(公告)日：2005-02-03

    申请号：US10927696

    申请日：2004-08-27

    Applicant: Cameron Koch ,  Alexander Kachur ,  Sydney Evans ,  Chyng-Yann Shiue ,  Ian Baird ,  Kirsten Skov ,  William Dolbier ,  An-Rong Li ,  Brian James

    Inventor： Cameron Koch ,  Alexander Kachur ,  Sydney Evans ,  Chyng-Yann Shiue ,  Ian Baird ,  Kirsten Skov ,  William Dolbier ,  An-Rong Li ,  Brian James

    IPC: C07D233/91 ,  C07D277/38 ,  C07K16/44 ,  A61K31/426

    CPC classification number: C07D233/91 ,  C07K16/44

    Abstract: Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.

    Abstract translation: 公开了包含新型硝基芳族化合物和载体蛋白质的新型硝基芳族化合物和免疫原性缀合物。 本发明还提供对所要求保护的硝基芳族化合物，化合物的蛋白质缀合物，化合物的还原副产物以及化合物和哺乳动物缺氧细胞组织蛋白质之间形成的加合物高度特异性的单克隆抗体。 本发明还涉及使用免疫组织化学技术，非侵入性核医学方法或核磁共振来检测组织缺氧的方法。 还提供了可用于实践所要求保护的发明的方法的诊断试剂盒。

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