公开(公告)号：US20120264727A1

公开(公告)日：2012-10-18

申请号：US13467019

申请日：2012-05-08

申请人： Young Lag CHO ,  Hye Jin HEO ,  Kyu Man OH ,  Hyang Sook LEE ,  Chul Soon PARK ,  Sang Eun CHAE ,  Joung Yul YUN ,  Hyun Jin KWON ,  Young Jae YANG ,  Dae Hyuck KANG ,  Yong Zu KIM ,  Sung Ho WOO ,  Tae Kyo PARK

发明人： Young Lag CHO ,  Hye Jin HEO ,  Kyu Man OH ,  Hyang Sook LEE ,  Chul Soon PARK ,  Sang Eun CHAE ,  Joung Yul YUN ,  Hyun Jin KWON ,  Young Jae YANG ,  Dae Hyuck KANG ,  Yong Zu KIM ,  Sung Ho WOO ,  Tae Kyo PARK

IPC分类号： A61K31/546 ,  A61P31/04 ,  C07D501/60

CPC分类号： C07D501/60 ,  C07D501/24 ,  C07D501/46

摘要： The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention.The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient.According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

摘要翻译： 本发明涉及由化学式1表示的新型头孢菌素衍生物。其中，X，Y，L，R 1和R 2与本发明的描述中所定义相同。 本发明还涉及药物抗生素组合物，其包含由化学式1表示的新型胞孢素衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为有效成分。 根据本发明，新型头孢菌素衍生物，其前体药物，其水合物，其溶剂化物，其异构体或其药学上可接受的盐作为有效成分，用于广谱抗生素抗性，低毒性，特别是革兰氏阴性 - 阴性细菌，其可用于具有强的抗微生物活性。

公开(公告)号：US08329684B2

公开(公告)日：2012-12-11

申请号：US13467019

申请日：2012-05-08

申请人： Young Lag Cho ,  Joung Yul Yun ,  Sang Eun Chae ,  Chul Soon Park ,  Hyang Sook Lee ,  Kyu Man Oh ,  Hye Jin Kang ,  Dae Hyuck Kang ,  Young Jae Yang ,  Hyun Jin Kwon ,  Tae Kyo Park ,  Sung Ho Woo ,  Young Zu Kim

发明人： Young Lag Cho ,  Joung Yul Yun ,  Sang Eun Chae ,  Chul Soon Park ,  Hyang Sook Lee ,  Kyu Man Oh ,  Hye Jin Kang ,  Dae Hyuck Kang ,  Young Jae Yang ,  Hyun Jin Kwon ,  Tae Kyo Park ,  Sung Ho Woo ,  Young Zu Kim

IPC分类号： A61K31/545 ,  C07D501/14

CPC分类号： C07D501/60 ,  C07D501/24 ,  C07D501/46

摘要： The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. Compounds of the present invention are effective ingredients for the broad spectrum of antibiotic resistance, exhibit low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

摘要翻译： 本发明涉及由化学式1表示的新型头孢菌素衍生物。其中，X，Y，L，R 1和R 2与本发明的描述中所定义相同。 本发明还涉及药物抗生素组合物，其包含由化学式1表示的新型胞孢素衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为有效成分。 本发明的化合物是广谱抗生素抗性的有效成分，表现出低毒性，特别是在革兰氏阴性细菌中，其可用于强抗微生物活性。

公开(公告)号：US20160213786A1

公开(公告)日：2016-07-28

申请号：US15054257

申请日：2016-02-26

申请人： Yong Zu Kim ,  Tae Kyo Park ,  Sung Ho Woo ,  Hyang Sook Lee ,  Sun Young Kim ,  Jong Un Cho ,  Doo Hwan Jung ,  Youngun Kim ,  Hyun Jin Kwon ,  Kyu Man Oh ,  Yunseo Chung ,  Yun Hee Park

发明人： Yong Zu Kim ,  Tae Kyo Park ,  Sung Ho Woo ,  Hyang Sook Lee ,  Sun Young Kim ,  Jong Un Cho ,  Doo Hwan Jung ,  Youngun Kim ,  Hyun Jin Kwon ,  Kyu Man Oh ,  Yunseo Chung ,  Yun Hee Park

IPC分类号： A61K47/48

CPC分类号： A61K47/6811 ,  A61K47/549 ,  A61K47/55 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6817 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6859 ,  A61K47/6889 ,  C07K16/2863 ,  C07K16/32 ,  C12Q1/48

摘要： The invention provides methods for preparing an antibody-active agent conjugate. The conjugate comprises an antibody, a cysteine residue of an amino acid motif that can be recognized by an isoprenoid transferase located at or after the carboxy-terminus of the antibody, an isoprenoid unit operably linked to the cysteine residue, and an active agen. The invention also provides a composition comprising the antibody-active agent conjugate prepared by the methods.

摘要翻译： 本发明提供了制备抗体 - 活性剂缀合物的方法。 缀合物包含抗体，氨基酸基序的半胱氨酸残基，其可被位于抗体的羧基末端或之后的类异戊二烯转移酶识别，与半胱氨酸残基可操作地连接的类异戊二烯单元和活性成分。 本发明还提供包含通过该方法制备的抗体 - 活性剂缀合物的组合物。