公开(公告)号：US20130109107A1

公开(公告)日：2013-05-02

申请号：US13698226

申请日：2011-05-25

Applicant: John C. Hutton ,  Janet M. Wenzlau ,  Howard W. Davidson ,  Thomas Gardner

Inventor： John C. Hutton ,  Janet M. Wenzlau ,  Howard W. Davidson ,  Thomas Gardner

IPC: G01N33/68

CPC classification number: G01N33/6854 ,  C07K16/40 ,  G01N33/564

Abstract: The detection of parietal cell autoimmune antibodies comprising an ATP4A D3.2 subdomain binding site can diagnose autoimmune body gastritis and/or pernicious anemia with extraordinary sensitivity and specificity that is far superior to existing commercial assays. Further, the assay has diagnostic applications for use in diagnosing type 1 diabetes, thyroiditis and Addison's disease. As pernicious anemia is typically a disease of the elderly, detection of parietal cell antibodies may precede clinical disease by many years if not decades, thereby allowing the initiation of therapeutic interventions such as vitamin B12 administration to prevent the development of pernicious anemia or immunologic interventions to prevent type 1 diabetes and its complications.

Abstract translation: 检测包含ATP4A D3.2亚结构域的壁细胞自身免疫抗体可以诊断具有非常灵敏度和特异性的自身免疫性胃炎和/或恶性贫血，远远优于现有的商业化验。 此外，该测定法具有用于诊断1型糖尿病，甲状腺炎和艾迪生病的诊断应用。 由于恶性贫血通常是老年人的疾病，所以顶层细胞抗体的检测可能在临床疾病之前多年，如果不是几十年，从而允许启动治疗干预措施例如维生素B12给药，以防止恶性贫血的发展或免疫干预 预防1型糖尿病及其并发症。