公开(公告)号：US5380930A

公开(公告)日：1995-01-10

申请号：US169088

申请日：1993-12-17

申请人： Herbert E. Fried

发明人： Herbert E. Fried

IPC分类号： C07C51/27 ,  C07C51/16 ,  C07C51/235 ,  C07C51/245

CPC分类号： C07C51/27

摘要： A process for the preparation of an alkoxyalkanoic acid by reacting the corresponding alkoxyalkanol with a stable free radical nitroxide in the presence of a NO.sub.x -generating compound, a solvent and an oxidant, at a temperature in the range of from about 0.degree. C. to about 100.degree. C. and thereafter separating out the alkoxyalkanoic acid.

摘要翻译： 在产生NO x的化合物，溶剂和氧化剂存在下，通过使相应的烷氧基烷醇与稳定的自由基氮氧化物在约0℃至约0℃的温度范围内反应制备烷氧基烷酸的方法， 约100℃，然后分离出烷氧基链烷酸。

公开(公告)号：US5175359A

公开(公告)日：1992-12-29

申请号：US752387

申请日：1991-08-30

申请人： Herbert E. Fried

发明人： Herbert E. Fried

IPC分类号： C07C51/235 ,  C07C51/27

CPC分类号： C07C51/235 ,  C07C51/27

摘要： A process for the preparation of an alkoxyalkanoic acid of the formulaRO(CH.sub.2 CHR'O).sub.n CH.sub.2 CO.sub.2 Hwherein R is an alkyl group of from 1 to about 22 carbon atoms, R' is hydrogen or methyl or mixtures thereof (on the individual molecule) and n is an integer of from 1 to about 20, which comprises reacting the corresponding alkoxyalkanol with a solubilized stable free radical nitroxide having the formula: ##STR1## wherein each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is an alkyl, aryl or heteroatom substituted alkyl group having 1 to about 15 carbon atoms and each of R.sub.5 and R.sub.6 is alkyl, hydrogen, aryl or a substituted heteroatom, a NO.sub.x -generating compound selected from the group consisting of an alkali metal nitrosodisulfonate, nitric acid, nitrous acid and mixtures thereof, and a chloride ion-containing compound in the presence of an oxidant at a temperature in the range of from about 0.degree. C. to about 100.degree. C. and thereafter separating out the alkoxyalkanoic acid.

摘要翻译： 制备式RO（CH 2 CHR'O）nCH 2 CO 2 H的烷氧基烷酸的方法，其中R是1至约22个碳原子的烷基，R'是氢或甲基或其混合物（在单个分子上）和 n是1至约20的整数，其包括使相应的烷氧基烷醇与具有下式的溶解的稳定的自由基氮氧化物反应：其中R 1，R 2，R 3和R 4各自为烷基，芳基或杂原子取代的烷基 具有1至约15个碳原子的基团，并且R 5和R 6各自为烷基，氢，芳基或取代的杂原子，选自碱金属亚硝基二磺酸盐，硝酸，亚硝酸及其混合物的产生NOx的化合物， 和含氯离子的化合物在氧化剂存在下，在约0℃至约100℃的温度范围内，然后分离出烷氧基链烷酸。

公开(公告)号：US5166423A

公开(公告)日：1992-11-24

申请号：US752388

申请日：1991-08-30

申请人： Herbert E. Fried

发明人： Herbert E. Fried

IPC分类号： C07C51/27

CPC分类号： C07C51/27

摘要： A process for the preparation of an alkanoic acid which comprises reacting the corresponding alkanol with a solubilized stable free radical nitroxide having the formula: ##STR1## wherein each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is an alkyl, aryl or heteroatom substituted alkyl group having 1 to about 15 carbon atoms and each of R.sub.5 and R.sub.6 is alkyl, hydrogen, aryl or a substituted heteroatom, and nitric acid in the presence of an oxidant at a temperature in the range of from about 25.degree. C. to about 65.degree. C. and thereafter separating out the alkanoic acid.

摘要翻译： 一种制备链烷酸的方法，其包括使相应的链烷醇与具有下式的溶解的稳定的自由基氮氧化物反应：其中R 1，R 2，R 3和R 4各自是烷基，芳基或杂原子取代的烷基，其具有 1至约15个碳原子，R5和R6各自为烷基，氢，芳基或取代杂原子，硝酸在氧化剂存在下，温度范围为约25℃至约65℃ 然后分离出链烷酸。

公开(公告)号：US5162579A

公开(公告)日：1992-11-10

申请号：US752386

申请日：1991-08-30

申请人： Herbert E. Fried

发明人： Herbert E. Fried

IPC分类号： C07C51/27

CPC分类号： C07C51/27

摘要： A process for the preparation of an alkoxyalkanoic acid of the formulaRO(CH.sub.2 CHR'O).sub.n CH.sub.2 CO.sub.2 Hwherein R is an alkyl group of from 1 to about 22 carbon atoms, R' is hydrogen or methyl or mixtures thereof (on the individual molecule) and n is an integer of from 1 to about 12, which comprises reacting the corresponding alkoxyalkanol with a stable free radical nitroxide having the formula: ##STR1## wherein each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is an alkyl, aryl or heteroatom substituted alkyl group having 1 to about 15 carbon atoms and each of R.sub.5 and R.sub.6 is alkyl, hydrogen, aryl or a substituted heteroatom, and nitric acid in the presence of an oxidant at a temperature in the range of from about 0.degree. C. to about 100.degree. C. and thereafter separating out the alkoxyalkanoic acid.

摘要翻译： 制备式RO（CH 2 CHR'O）nCH 2 CO 2 H的烷氧基烷酸的方法，其中R是1至约22个碳原子的烷基，R'是氢或甲基或其混合物（在单个分子上）和 n是1至约12的整数，其包括使相应的烷氧基烷醇与具有下式的稳定的自由基硝基氧反应：其中R1，R2，R3和R4各自为烷基，芳基或杂原子取代的烷基 具有1至约15个碳原子，并且在氧化剂存在下，在约0℃至约100℃的温度下，R 5和R 6各自为烷基，氢，芳基或取代的杂原子，硝酸。 然后分离出烷氧基链烷酸。

公开(公告)号：US5155279A

公开(公告)日：1992-10-13

申请号：US776777

申请日：1991-10-18

申请人： Herbert E. Fried

发明人： Herbert E. Fried

IPC分类号： C07C45/29

CPC分类号： C07C45/29

摘要： A process for the preparation of an aldehyde which comprises reacting the corresponding alkanol with a solubilized stable free radical nitroxide having the formula: ##STR1## wherein each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is an alkyl, aryl or heteroatom substituted alkyl group having 1 to about 15 carbon atoms and each of R.sub.5 and R.sub.6 is alkyl, hydrogen, aryl or a substituted heteroatom, nitric acid and a solvent, in the absence of an oxidant at a temperature in the range of from about -10.degree. C. to about 60.degree. C. and thereafter separating out the aldehyde.

摘要翻译： 一种制备醛的方法，其包括使相应的链烷醇与具有下式的增溶的稳定的自由基氮氧化物反应：其中R 1，R 2，R 3和R 4各自为烷基，芳基或杂原子取代的烷基，其具有1 至约15个碳原子，并且在不存在氧化剂的情况下，R 5和R 6各自为烷基，氢，芳基或取代的杂原子，硝酸和溶剂，温度范围为约-10℃至约 然后分离出醛。

公开(公告)号：US5136102A

公开(公告)日：1992-08-04

申请号：US779454

申请日：1991-10-18

申请人： Herbert E. Fried

发明人： Herbert E. Fried

IPC分类号： C07C45/29

CPC分类号： C07C45/29

摘要： A process for the preparation of a ketone which comprises reacting the corresponding secondary alkanol with a solubilized stable free radical nitroxide having the formula: ##STR1## wherein each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is an alkyl, aryl or heteroatom substituted alkyl group having 1 to about 15 carbon atoms and each of R.sub.5 and R.sub.6 is alkyl, hydrogen, aryl or a substituted heteroatom, nitric acid, and a bromide ion-containing compound in the presence of an oxidant at a temperature in the range of from about -10.degree. C. to about 60.degree. C. and thereafter separating out the ketone.

摘要翻译： 一种制备酮的方法，其包括使相应的仲链烷醇与具有下式的溶解的稳定的自由基氮氧化物反应：其中R1，R2，R3和R4各自为烷基，芳基或杂原子取代的烷基，其具有 1至约15个碳原子，并且在氧化剂存在下，在约-10℃的温度下，R 5和R 6各自为烷基，氢，芳基或取代的杂原子，硝酸和含溴离子的化合物 约60℃，然后分离出酮。

公开(公告)号：US5136101A

公开(公告)日：1992-08-04

申请号：US769072

申请日：1991-09-30

申请人： Herbert E. Fried

发明人： Herbert E. Fried

IPC分类号： C07C45/29

CPC分类号： C07C45/29

摘要： A process for the preparation of a ketone which comprises reacting the corresponding secondary alkanol with a solubilized stable free radical nitroxide having the formula: ##STR1## wherein each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is an alkyl, aryl or heteroatom substituted alkyl group having 1 to about 15 carbon atoms and each of R.sub.5 and R.sub.6 is alkyl, hydrogen, aryl or a substituted heteroatom, and an alkali metal nitrosodisulfonate in the presence of an oxidant at a temperature in the range of from about -10.degree. C. to about 80.degree. C. and thereafter separating out the ketone.

摘要翻译： 一种制备酮的方法，其包括使相应的仲链烷醇与具有下式的溶解的稳定的自由基氮氧化物反应：其中R1，R2，R3和R4各自为烷基，芳基或杂原子取代的烷基，其具有 1至约15个碳原子，R 5和R 6各自为烷基，氢，芳基或取代的杂原子，和碱金属亚硝基二磺酸盐，在氧化剂存在下，温度范围为约-10℃至约 80℃，然后分离出酮。

公开(公告)号：US5401874A

公开(公告)日：1995-03-28

申请号：US263167

申请日：1994-06-21

申请人： Herbert E. Fried

发明人： Herbert E. Fried

IPC分类号： C07C51/31 ,  C07C51/16

CPC分类号： C07C51/316

摘要： A process for preparing an alkoxyalkanoic acid by reacting the corresponding alkoxyalkanol with a stable free radical nitroxide in the presence of a NO.sub.x -generating compound and, optionally, an oxidant at a temperature in the range of from about 0.degree. C. to about 100.degree. C. and thereafter separating out the alkoxyalkanoic acid.

摘要翻译： 在产生NO x的化合物和任选的氧化剂存在下，在约0℃至约100℃的温度范围内使相应的烷氧基烷醇与稳定的自由基氮氧化物反应制备烷氧基烷酸的方法 然后分离出烷氧基链烷酸。

公开(公告)号：US5256819A

公开(公告)日：1993-10-26

申请号：US996268

申请日：1992-12-24

申请人： Herbert E. Fried

发明人： Herbert E. Fried

IPC分类号： B01J27/24 ,  C07B61/00 ,  C07C51/235 ,  C07C51/27 ,  C07C59/305 ,  C08G65/32 ,  C08G65/324 ,  C08G65/325 ,  C07C51/16

CPC分类号： C08G65/325 ,  C07C51/27 ,  C08G65/324

摘要： A process for the preparation of a polyoxyalkylene-alpha,omega-dicarboxylic acid by reacting the corresponding polyoxyalkylene glycol with a stable free radical nitroxide in the presence of a NO.sub.x -generating compound and optionally, an oxidant and/or a solvent, at a temperature in the range of from about 0.degree. C. to about 100.degree. C. and thereafter separating out the polyoxyalkylene-alpha,omega-dicarboxylic acid.

摘要翻译： 在产生NO x的化合物和任选的氧化剂和/或溶剂存在下，通过使相应的聚氧亚烷基二醇与稳定的自由基的氮氧化物反应来制备聚氧化烯-α，ω-二羧酸的方法， 在约0℃至约100℃的范围内，然后分离出聚氧化烯-α，ω-二羧酸。

公开(公告)号：US5175360A

公开(公告)日：1992-12-29

申请号：US618205

申请日：1990-11-26

申请人： Herbert E. Fried

发明人： Herbert E. Fried

IPC分类号： C07C51/29 ,  C07C59/125 ,  C11D1/06

CPC分类号： C07C51/29

摘要： This invention relates to a process for the preparation of an alkoxyalkanoic acid of the formulaRO(CH.sub.2 CHR'O).sub.n CH.sub.2 CO.sub.2wherein R is an alkyl group of from 1 to about 22 carbon atoms, R' is hydrogen or methyl or mixtures thereof (on the individual molecule) and n is an integer of from 1 to about 12 which comprises reacting the corresponding alkoxyalkanol with a solubilized stable free radical nitroxide having the formula: ##STR1## wherein (1) (a) each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is an alkyl, aryl or heteroatom substituted alkyl group having 1 to about 15 carbon atoms, and (b) R.sub.5 and R.sub.6 (i) each is an alkyl group having 1 to about 15 carbon atoms provided that when R.sub.1 -R.sub.6 are not all alkyl groups, or a substituted alkyl group having 1 to about 15 carbon atoms wherein the substituent is halogen, cyano, --CONH.sub.2, --OCOCH, OCOC.sub.2 H.sub.5, carbonyl, alkenyl wherein the double bond is not conjugated with the nitroxide moiety, or --COOR wherein R of the --COOR group is alkyl or aryl, or (ii) together form part of a ring that contains 5 carbon atoms and up to two heteroatoms of O or N, or (2) the ##STR2## moiety and the ##STR3## moiety individually are aryl, in the presence of a chlorine-containing oxidant at a temperature in the range of from about -10.degree. C. to about 35.degree. C. and thereafter separating out the alkoxyalkanoic acid.