公开(公告)号：US5464828A

公开(公告)日：1995-11-07

申请号：US185157

申请日：1994-01-24

Applicant: Masahide Katayama ,  Harushige Yamashita ,  Taizo Okada ,  Shigeo Morioka

Inventor： Masahide Katayama ,  Harushige Yamashita ,  Taizo Okada ,  Shigeo Morioka

IPC: A61K9/00 ,  A61K31/70

CPC classification number: A61K9/0095 ,  A61K31/70

Abstract: The invention is an aqueous suspension of sucralfate (sucrose sulfate aluminum salt), which is added with a starch and/or a derivative thereof and preferably further with a cellulose derivative, polysaccharide gum, alginic acid, alginate and/or bentonite, whereby the suspension is made stable for a long time and may be redispersed if necessary. The invention can thus provide a liquid pharmaceutical preparation useful for protecting ulcer areas on mucous membranes of the stomach and duodenum industrially for the first time, although solid pharmaceutical preparations have been available.

Abstract translation: 本发明是硫糖铝（蔗糖硫酸铝盐）的水性悬浮液，其中加入淀粉和/或其衍生物，优选还含有纤维素衍生物，多糖胶，藻酸，藻酸盐和/或膨润土，由此悬浮液 长时间保持稳定，如有需要，可以再分散。 因此，本发明可以提供用于在第一次保护胃和十二指肠粘膜上的溃疡区域的液体药物制剂，尽管固体药物制剂已经可用。