公开(公告)号：US20170226073A1

公开(公告)日：2017-08-10

申请号：US15502301

申请日：2015-08-07

申请人： Han W. TUN ,  Thomas R. CAULFIELD ,  Christina VON ROEMELING ,  Laura Ann MARLOW ,  Mayo Foundation for Medical Education and Research

发明人： John A. Copland, III ,  Han W. Tun ,  Thomas R. Caulfield ,  Christina Von Roemeling ,  Laura Ann Marlow

IPC分类号： C07D295/192 ,  C07D213/75 ,  A61K31/495 ,  C07D211/66 ,  A61K31/496 ,  A61K31/44 ,  C07D213/64

CPC分类号： C07D295/192 ,  A61K31/44 ,  A61K31/495 ,  A61K31/496 ,  A61K45/06 ,  C07D211/64 ,  C07D211/66 ,  C07D213/64 ,  C07D213/75 ,  A61K2300/00

摘要： This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.