公开(公告)号：US20150157675A1

公开(公告)日：2015-06-11

申请号：US14389957

申请日：2012-04-02

申请人： Hyun Seok Kim ,  Ki Moon Park ,  Min Ji Kim ,  Youngmin Lee ,  Haeng Ran Kim ,  Kang Jin Cho

发明人： Hyun Seok Kim ,  Ki Moon Park ,  Min Ji Kim ,  Youngmin Lee ,  Haeng Ran Kim ,  Kang Jin Cho

IPC分类号： A61K36/28 ,  A23L2/52 ,  A61K9/48 ,  A23L1/30 ,  A61K9/14 ,  A61K9/20

CPC分类号： A61K36/28 ,  A23L2/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/14 ,  A61K9/20 ,  A61K9/48 ,  A23V2200/332 ,  A23V2250/156 ,  A23V2250/21 ,  A23V2250/702 ,  A23V2250/704 ,  A23V2250/708 ,  A23V2250/72

摘要： The present invention relates to a Eupatorium spp. extract having anti-obesity effects as a result of decreasing adipocytes and increasing osteoblasts, as well as the effects of preventing bone disease or fractures by increasing osteoblasts and of preventing osteoporosis by decreasing adipocytes and increasing osteoblasts by the same proportion in mesenchymal stem cells. DCM fraction layers of a Eupatorium spp. stem extract collected on a monthly basis and Eupatorium spp. stem extract collected only in September may inhibit the activity of PPARγ, AP2, CD36, adiponectin C/EBPα, and LPL, which serve as significant factors for adipocyte differentiation in C3H10T1/2 cells and primary mesenchymal stem cells, which are pluripotent stem cell lines, and may increase the activity of ALP, osterix, CO1I and RUNX2, which serve as significant factors for osteoblast differentiation. The Eupatorium spp. extract of the present invention exhibits the effects of increasing bone mineral density (BMD) and decreasing adipocytes in bone marrow in an osteoporosis animal model experiment involving an ovariectomy, and therefore may be used as a useful material for preventing and treating osteoporosis.

摘要翻译： 本发明涉及一种番茄属（Eupatorium spp。） 提取物具有作为脂肪细胞减少和成骨细胞增加的结果的抗肥胖效果，以及通过增加成骨细胞并通过减少脂肪细胞并在间充质干细胞中以相同比例增加成骨细胞来预防骨质疏松症来预防骨质疏松症的效果。 紫杉属的DCM级分层。 每月收集茎提取物和紫茎泽兰属 仅在9月份收集的茎提取物可能抑制PPARγ，AP2，CD36，脂联素C /EBPα和LPL的活性，其作为C3H10T1 / 2细胞和原代间充质干细胞的脂肪细胞分化的重要因子，其为多能干细胞系 ，并且可能增加ALP，osterix，CO1I和RUNX2的活性，其作为成骨细胞分化的重要因素。 紫ium属 本发明的提取物在涉及卵巢切除术的骨质疏松动物模型实验中表现出增加骨矿物质密度（BMD）和减少骨髓中的脂肪细胞的作用，因此可用作预防和治疗骨质疏松症的有用材料。