公开(公告)号：US5612016A

公开(公告)日：1997-03-18

申请号：US038416

申请日：1993-03-29

Applicant: Gary L. Griffiths ,  Habibe Diril ,  Hans J. Hansen

Inventor： Gary L. Griffiths ,  Habibe Diril ,  Hans J. Hansen

IPC: G01N33/547 ,  A61K38/00 ,  A61K45/00 ,  A61K47/48 ,  A61K49/00 ,  A61K51/00 ,  A61K51/10 ,  A61K51/12 ,  A61P35/00 ,  C07K16/06 ,  C07K16/10 ,  C07K16/30 ,  G01N33/534 ,  G01N33/553 ,  G01N33/574 ,  G01N33/68

CPC classification number: A61K47/48523 ,  A61K47/48569 ,  A61K51/10 ,  A61K51/1018 ,  A61K51/1048 ,  A61K51/1093 ,  A61K51/1282 ,  C07K16/065 ,  C07K16/1063 ,  C07K16/30 ,  G01N33/534 ,  G01N33/6857 ,  A61K2121/00 ,  A61K2123/00 ,  A61K38/00

Abstract: Provided are conjugates useful in cancer, cardiovascular or infectious disease detection and/or therapy. The conjugate is of a ligand and protein. The ligand has a moiety capable of binding to mercapto groups and is capable of chelating a metal useful for detection or therapy. The protein reacts with a substance associated with a targeted cell, pathologic lesion or pathogen. The protein prior to conjugation has at least one mercapto group which becomes a site for conjugation to the ligand. Also provided are metal chelates of the conjugate, methods of detection and therapy, methods for producing the conjugate and pharmaceuticals compositions of the conjugates.

Abstract translation: 提供可用于癌症，心血管或感染性疾病检测和/或治疗的缀合物。 缀合物是配体和蛋白质。 配体具有能够结合巯基并能够螯合可用于检测或治疗的金属的部分。 蛋白与与靶细胞，病理损伤或病原体相关的物质反应。 缀合前的蛋白质具有至少一个巯基，其成为与配体结合的位点。 还提供了缀合物的金属螯合物，检测和治疗方法，生产缀合物的方法和缀合物的药物组合物。